Publications by authors named "Huaipeng Guo"
Objective: We aim to evaluate the efficacy and safety of blinatumomab for the treatment of post-transplant relapse patients with acute lymphoblastic leukemia (ALL).
Methods: The search was conducted using several databases including the PubMed, Cochrane Library, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang Data Knowledge Service Platform to collect clinical studies related to blinatumomab. The primary outcome measures were complete remission (CR), 1-year overall survival (OS), 2-year OS, median OS and adverse events (AEs).
Background: Primary central nervous system lymphoma (PCNSL) is an aggressive lymphoma that primarily affects the central nervous system. Current treatments, such as surgery, chemotherapy, and whole-brain radiotherapy, often fail to achieve satisfactory results. The prognosis for patients with refractory or relapsed (R/R) PCNSL is bleak.
View Article and Find Full Text PDFObjective: This article conducts a systematic review of eltrombopag combined with immunosuppressive therapy for the treatment of aplastic anemia (AA), to demonstrate the effectiveness and safety of eltrombopag.
Methods: PubMed, Cochrane Library, Embase, OVID, Web of Science, China National Knowledge Infrastructure, and Wanfang databases were searched. Studies that met the inclusion criteria were collected, ranging from the establishment of the database to August 2023.
Electromagnetic Radiation Exposure and Childhood Leukemia: Meta-Analysis and Systematic Review.
Altern Ther Health Med
November 2023
Objective: Leukemia is the most prevalent cancer among children and adolescents. This study investigated the potential association between exposure to magnetic fields and the risk of pediatric leukemia.
Methods: We conducted a comprehensive search of electronic databases, including Scopus, EMBASE, Cochrane, Web of Science, and Medline, up to December 15, 2022, to identify relevant studies examining the link between childhood leukemia and magnetic field exposure.
[Analysis of Gene Mutation Characteristics and Prognosis of Elderly Patients with Acute Myeloid Leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2022
Objective: To investigate the characteristics of gene mutation in elderly patients with acute myeloid leukemia (AML) and its effect on prognosis.
Methods: The clinical and laboratorial characteristics of 54 AML patients (≥60 years old) in Department of Hematology, Tangdu Hospital were analyzed retrospectively during April 2016 to October 2019. Thirty-four AML/myelodysplastic syndrome/myeloproliferative neoplasm related mutant genes were detected by second-generation sequencing technology, and their clinical characteristics, treatment effect, and influence on prognosis were analyzed.
[Clinical Characteristics and Prognosis of Acute Myeloid Leukemia Patients with ASXL1 Gene Mutation].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2021
Article Synopsis
- The study focused on the clinical characteristics and outcomes of acute myeloid leukemia (AML) patients with ASXL1 mutations, analyzing data from 229 newly diagnosed patients.
- Out of the patients studied, 19.6% had ASXL1 mutations, with frameshift mutations being the most frequent, and patients typically being older men with a history of myelodysplastic syndrome (MDS) or myeloproliferative neoplasms (MPN) and low initial white blood cell counts.
- Patients with ASXL1 mutations had a lower complete response (CR) rate compared to those without, and while there was a significant difference in survival rates up to 20 months, this difference was not observed beyond