Electroacupuncture activates angiogenesis by regulating the PI3K/Pten/Thbs1 signaling pathway to promote the browning of adipose tissue in HFD-induced obese mice.

This study investigated the effect of electroacupuncture (EA) on the browning of white adipose tissue (WAT) via angiogenesis and its potential mechanism in obese mice. Four-week-old male C56BL/6 mice were randomly divided into a high-fat diet (HFD) and a normal chow diet (ND) group. After 12 weeks, HFD mice were randomly divided into two groups to receive or not receive EA for 3 weeks.

Electroacupuncture for weight loss by regulating microglial polarization in the arcuate nucleus of the hypothalamus.

Electroacupuncture (EA) has a weight loss effect, but the underlying molecular mechanisms of weight loss with EA have not been fully elucidated. This study aimed to investigate the modulatory effects of EA on the phenotype of hypothalamic microglia in obese mice. A total of 50 male C57BL/6J mice were used in this study.

Hyperoxia combined with the B-cell antagonist rituximab led to intestinal dysbiosis in neonatal mice.

The adverse factors impacting the intestinal microbiota of newborns remain to be elucidated. We put forward a hypothesis that hyperoxia in combination with rituximab exhibits a synergistic effect that interferes with neonatal intestinal microbiota. Six C57BL/6J mice, aged 12 weeks and pregnant 18 days, were purchased.

Electroacupuncture facilitates M2 macrophage polarization and its potential role in the regulation of inflammatory response.

The underlying mechanism of electroacupuncture (EA) in relieving obesity, anti-inflammation and the interaction with metabolic pathways in obese mice has not been elaborated. The aim of this study was to investigate the regulation of EA on macrophage polarization in obesity tissue of diet-induced obesity mice. Mice were divided in 6 groups: normal control group, model group, EA-7 group, EA-14 group, EA-21 group and EA-28 group.

Pathological Impact on the Phyllosphere Microbiota of by Haze.

The pathological impact of haze upon the phyllosphere microbiota awaits investigation. A moderate degree of haze environment and a clean control were selected in Chengdu, China. , a ubiquitously distributed and extensively applied Chinese herb, was also chosen for experiment.

Commensal microbe-derived propionic acid mediates juvenile social isolation-induced social deficits and anxiety-like behaviors.

Social experiences during early life are thought to be critical for proper social and emotional development. Conversely, social insults during development causes long-lasting behavioral abnormalities later in life. However, how juvenile social deprivation influences social and emotional behaviors remains poorly understood.

[Expression and significance of P53 and P21 in nasal NK/T-cell lymphoma].

Objective: To investigate the significance of P53 and P21 expressions in nasal NK/T-cell lymphoma (NKTL) and their relationships with the clinical stage, prognosis, proliferation and apoptosis of tumor cells.

Methods: The clinicopathologic and follow-up data was collected from 62 patients with NKTL proven by pathological examination. Sixty-two cases of NKTL were examined for P53, P21 and Ki67 proteins with tissue microarray technique and immunohistochemistry.

[Expression and significance of p53-related proteins and LMP-1 in nasal NK/T-cell lymphoma].

Objective: To investigate the expression of murine double minute 2 (mdm2), p53, p21 and latent membrane protein 1 (LMP-1) in nasal NK/T-cell lymphoma (NKTL) and analyze their relationship with the clinical stage and prognosis.

Methods: The clinicopathological and follow-up data of 62 patients with NKTL proven by pathology were collected. Paraffin-embedded tissue sections were examined for mdm2, p53, p21 and LMP-1 proteins by tissue microarray technique and immunohistochemistry.

[Expressions of p53 and p21 in nasal NK/T-cell lymphoma and their relationship with the proliferation and apoptosis of cells].

Objective: To investigate the significance of expressions of p53 and p21 in nasal NK/T-cell lymphoma (NKTL) and their relationship with cell proliferation and apoptosis.

Method: Sixty-two cases of NKTL were examined for p53, p21 and Ki67 proteins by means of tissue microarray technique, TUNEL and immunohistochemistry. The proliferation index (PI) was determined by expression of Ki67 proteins.

[Analysis of clinicopathological features and prognostic factors of 62 nasal NK/T-cell lymphomas].

Objective: To investigate the clinicopathological features and prognostic factors of nasal NK/T-cell lymphoma.

Method: The clinicopathological data, treatment modality and survival status were analyzed.

Result: The overall five year survival rate of: 62 patients was 63.

[Four cases of primary neuroendocrine carcinoma in ear, nose, pharynx and larynx].

Objective: To discuss the clinical pathologic features and therapeutic method of the primary neuroendocrine carcinoma in ear, nose, pharynx, larynx.

Method: One case of atypical carcinoid tumor in larynx is treated by epiglottidectomy. One case of atypical carcinoid tumor in rhinopharynx is treated by radiotherapy.

[Clinical analysis to 36 cases of acute laryngeal damage].

Objective: To research the way to deal with the acute laryngeal damage.

Method: Data of 36 cases with acute laryngeal damage were analyzed.

Result: Among 36 cases, there were 10 cases who received non-surgical treatment and their phonation was normal except 2 cases who had mild hoarseness.