IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer via facilitating PD-L1 endosome recycling.

As an immune checkpoint protein expressed by diverse cancer cells, programmed death ligand 1 (PD-L1) facilitates immune evasion by interacting with programmed cell death-1 (PD-1) on T cells. Despite the clinical benefits observed in various cancer types, strategies targeting PD-1/PD-L1 have demonstrated limited efficacy in gastric cancer (GC). Furthermore, the regulation of PD-L1, especially at post-translational modification levels, remains largely unknown.

Joint optic disc and cup segmentation based on elliptical-like morphological feature and spatial geometry constraint.

Glaucoma is a chronic degenerative disease that is the second leading cause of irreversible blindness worldwide. For a precise and automatic screening of glaucoma, detecting the optic disc and cup precisely is significant. In this paper, combining the elliptical-like morphological features of the disc and cup, we reformulate the segmentation task from a perspective of ellipse detection to explicitly segment and directly get the glaucoma screening indicator.

Differences in Neuropathic Pain and Radiological Features Between AQP4-ON, MOG-ON, and IDON.

Purpose: The purpose of this study was to investigate pain and radiological features of different types of first-episode demyelinating optic neuritis (ON).

Methods: Eighty-three patients presenting with first-episode aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; = 28), myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; = 26) and idiopathic demyelinating optic neuritis (IDON, = 29) were included in this retrospective case-control study. We assessed optic nerve lesions on magnetic resonance imaging (MRI), acute pain associated with onset of optic neuritis and clinical characteristics of those ON patients with different serum autoantibody status.

Down-Regulated CLDN10 Predicts Favorable Prognosis and Correlates With Immune Infiltration in Gastric Cancer.

CLDN10, an important component of the tight junctions of epithelial cells, plays a crucial role in a variety of tumors. The effect of CLDN10 expression in gastric cancer, however, has yet to be elucidated. Differential expression of CLDN10 at the mRNA and protein levels was evaluated using Oncomine, ULCAN, HPA and TIMER2.

A Novel sRNA in That Regulates Tolerance and Virulence Under Hyperosmotic Pressure.

Regulation of the environmental stress response and virulence of may involve multiple signaling pathways; however, these mechanisms are not well-defined. In bacteria, small regulatory RNAs (sRNAs) regulate bacterial growth, metabolism, virulence, and environmental stress response. Therefore, identifying novel functional sRNAs in could help elucidate pathogenic adaptations to host micro-environmental stresses and associated virulence.

[Usefulness of self-made gasbag double-cannula stool drainage device for prevention of anastomotic leakage following anterior resection].

Objective: To evaluate the efficacy of self-made gasbag double-cannula stool drainage device for prevention of anastomotic leakage following anterior resection.

Methods: Clinical data of 169 rectal cancer patients in the 8th Affiliated Hospital of Sun Yat-sen University between October 2010 and October 2016 were retrospectively analyzed. Among them, a self-made gasbag double-cannula stool drainage device was placed in 71 patients(stool drainage group), and the remaining 98 patients were taken as control.

A new classification for epidemiological study of mechanical eye injuries.

Objective: Considering the difficulty in classifying some cases with eye trauma by Birmingham Eye Trauma Terminology (BETT) in our epidemiological study, we introduce a new classification for epidemiological study of mechanical eye injuries based on BETT.

Methods: A retrospective investigation was carried out in 31 hospitals from January 2005 to December 2010. All medical records of inpatients with eye injuries were reviewed.

Characterization of retinal nerve fiber layer thickness changes associated with Leber's hereditary optic neuropathy by optical coherence tomography.

In the present study, the changes in the retinal nerve fiber layer (RNFL) thickness associated with Leber's hereditary optic neuropathy (LHON) were examined by Cirrus high definition-optical coherence tomography (OCT), and the correlation between the RNFL thickness and the best corrected visual acuity (BCVA) was evaluated. A cross-sectional study was performed. Sixty-eight eyes from patients with LHON and 30 eyes from healthy individuals were scanned.

Ocular manifestations of intracranial germinomas: three cases report and literature review.

Intracranial germinomas are malignant neoplasms of gonadal origin, which have some features in terms of age, sex, and clinical manifestations. They mainly occur in children and adolescents. Patients with intracranial germinomas mainly manifest with hypothalamic pituitary axis dysfunction and/or compression syndromes.

Clinical analysis of the etiology of optic neuritis in patients at different ages in china.

Purpose: To determine the etiology of optic neuritis in patients of different ages in China.

Methods: Records of optic neuritis patients who were hospitalized in the Department of Neuro-ophthalmology, General PLA Hospital, Beijing, between January 1, 2011 and December 31, 2011 were retrospectively reviewed.

Results: A total of 132 patients were divided into three groups by age.

Laser in situ keratomileusis surgery is not safe for military personnel.

Objective: To investigate the relationship between eye injury and laser in-situ keratomileusis (LASIK) surgery in military personnel.

Methods: This retrospective study collected the data from 27 evacuation hospitals of Chinese army. All medical records of eye injuries in military personnel admitted to the 27 hospitals between January 2006 and December 2010 were reviewed.

[Analysis on characteristics of ocular trauma caused by military affairs in soldiers].

Objective: To investigate and analyze the epidemiological, clinical and prognostic characteristics of ocular trauma in soldiers caused by military affairs and compared with those in trauma caused by non-military causes.

Methods: A retrospective study on eye injury cases of military inpatients in 15 military general hospitals from 2001 to 2005 was performed and the data of 716 cases (772 eyes) were statistically analyzed.

Results: Three hundred and sixty inpatients (398 eyes) caused by military affairs accounted for 50.

Epidemiology of eye injuries sustained by military personnel in China.

Objective: To investigate the epidemiological characteristics of eye injuries sustained by military personnel in Chinese army.

Methods: Eleven military evacuation hospitals located in different regions were selected for this study. We reviewed all the medical records of eye injuries sustained by military personnel between January 2005 and December 2009.

The survey of the causes of eye injury of various services in China.

The cause of eye injury in various services may be different. Preventing the injury according to the cause would be more effective. We investigated 502 (549 eyes) cases of ocular injury in 21 military hospitals in China.

[Epidemiological characteristics of eye injury among soldiers in 15 military hospitals].

Objective: To investigate and analyze the epidemiological characteristics of eye injury among military inpatients.

Methods: Data of eye injury among military inpatients from 15 military general hospitals during 2001 - 2005 were recorded and statistically analyzed.

Results: There were 716 military inpatients with eye injuries, taking up 7.