Association between gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis.

Background: Major depressive disorder (MDD) is a substantial global health concern, and its treatment is complicated by the variability in individual response to antidepressants.

Aim: To consolidate research and clarify the impact of genetic variation on MDD treatment outcomes.

Methods: Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search across PubMed, EMBASE, Web of Science, and the Cochrane Library was conducted without date restrictions, utilizing key terms related to MDD, serotonin 1A receptor polymorphism (5-HTR1A), C-1019G polymorphism, and antidepressant response.

The safety of benzodiazepines and related drugs during pregnancy: an updated meta-analysis of cohort studies.

Purpose: The prevalence of benzodiazepines and related drugs (BZRDs) use during pregnancy increased sharply in recent years. Thus, there are concerns regarding the pregnancy outcomes following exposure to BZRDs.

Methods: Two electronic databases were thoroughly searched to identify related clinical studies published from inception until June 2023.