Ozone-Induced Lung Injury are Mediated Via PPAR-Mediated Ferroptosis in Mice.

In recent years, the concentration of PM in China has decreased, while the concentration of ozone remains rising. Exposure to ozone contributes to respiratory illnesses; however, little is known about the underlying molecular mechanisms. The present study established an ozone-induced lung injury mice model to investigate potential molecular biomarkers and toxic mechanisms.

Concurrent ozone and high temperature exacerbates nasal epithelial barrier damage in allergic rhinitis mice: Insights from the nasal transcriptome and nasal microbiota.

The global ambient temperature has been rising in recent decades and high temperature is usually accompanied by ozone (O) pollution. Environmental change is an underlying factor for the increased prevalence of respiratory allergic disease. However, the potential mechanisms are complex and remain elusive.

Development of an investigation form for hemodialysis infection outbreak: Identifying sources in the early stage.

Background: There are many infectious factors causing the outbreak of hemodialysis infection, which may easily lead to the delay of investigation and treatment. This study aimed to develop an investigation form for hemodialysis infection outbreak (HIO), and to identify sources of outbreak in early stage.

Methods: After an exhaustive literature review, we used the Delphi method to determine the indicators and relative risk scores of the assessment tools through 2 rounds of specialist consultation and overall consideration of the opinions and suggestions of 18 specialists.

Construction of a postoperative infection outbreak investigation form: A tool for early detection and control measures.

Background: To develop an investigation form for postoperative infection outbreak (PIO), and to identify sources of the outbreak in the early stage.

Methods: After an exhaustive literature review, we used the Delphi method to determine the indicators and relative risk scores of the assessment tools through 2 rounds of specialist consultation and overall consideration of the opinions and suggestions of 20 specialists.

Results: A total of 203 studies of PIO were eligible for inclusion.

Circulating plasma galectin-3 predicts new-onset atrial fibrillation in patients after acute myocardial infarction during hospitalization.

Background: New-onset atrial fibrillation (NOAF) is a common complication in patients with acute myocardial infarction (AMI) during hospitalization. Galectin-3 (Gal-3) is a novel inflammation marker that is significantly associated with AF. The association between post-AMI NOAF and Gal-3 during hospitalization is yet unclear.

An Exploration and Technical Notes for Advanced Airway Management on the Ski Slope: A Simulation Experiment.

Background: Skiing is a high-risk winter sport, and the rate of injury fatality is the highest compared to other winter sports. During skiing rescue, the harsh natural environments will increase the difficulty of artificial airway establishment. There has been no research focusing on the establishment of the artificial airway during skiing rescue site.

Serial disseminated intravascular coagulation score with neuron specific enolase predicts the mortality of cardiac arrest-a pilot study.

Background: Prognosis in cardiac arrest (CA) patients has been challenging. We sought to investigate prognostic value combining serial disseminated intravascular coagulation (DIC) score and neuron-specific enolase (NSE) in out-of-hospital cardiac arrest (OHCA) patients.

Methods: Sixty-one consecutive patients successfully resuscitated after CA were included in the analysis.

Distribution and drug resistance of pathogenic bacteria in emergency patients.

Background: Antibiotic resistance has become a global threat for human health, calling for rational use of antibiotics.

Aim: To analyze the distribution and drug resistance of the bacteria, providing the prerequisite for use of antibiotics in emergency patients.

Methods: A total of 2048 emergency patients from 2013 to 2017 were enrolled.

Numerical investigation of GHz repetition rate fundamentally mode-locked all-fiber lasers.

GHz repetition rate fundamentally mode-locked lasers have attracted great interest for a variety of scientific and practical applications. A passively mode-locked laser in all-fiber format has the advantages of high stability, maintenance-free operation, super compactness, and reliability. In this paper, we present numerical investigation on passive mode-locking of all-fiber lasers operating at repetition rates of 1-20 GHz.

[Seasonal fluctuations of mosquitoes and application of two surveillance tools in Taibai Lake area of Jining City].

Objective: To investigate the seasonal fluctuations of mosquitoes in Taibai Lake area of Jining City, and evaluate the application effects of two mosquito trapping tools (Gongfu Xiaoshuai mosquito lamp and WJ-C mosquito sampler), so as to provide references for the effective surveillance, prevention and control of local mosquito vectors.

Methods: The overnight capture of mosquitoes with a man-bait net trap, Gongfu Xiaoshuai mosquito lamp, and WJ-C mosquito sampler was performed to collect mosquitoes. The species of adult mosquitoes and seasonal fluctuations were investigated and analyzed.

Admission macrophage migration inhibitory factor predicts long-term prognosis in patients with ST-elevation myocardial infarction.

Aims: We previously showed in patients with ST-segment elevated myocardial infarction (STEMI) that admission levels of macrophage migration inhibitory factor (MIF) predict infarct size. We studied whether admission MIF alone or in combination with other biomarkers is useful for risk assessment of acute and chronic clinical outcomes in STEMI patients.

Methods And Results: A total of 658 STEMI patients treated with primary percutaneous coronary intervention (PCI) were consecutively recruited.

[Analysis of population genetic diversity of mosquitoes from Shandong Province based on mitochondrial DNA cytochrome oxidase subunit I gene fragment].

Objective: To explore the characteristics of gene sequence of mtDNA-COⅠ of from different geographical regions in Shandong Province and different resistant strains from the lab and five common mosquito species, and analyze the genetic diversity of these mosquitoes.

Methods: Adult mosquitoes were collected from Jinan, Jining, Qingdao cities and other places in Shandong Province. The sensitive, dichlorvos-resistant, pyrethroid-resistant and propoxur-resistant strains were reared in the lab.

General description and understanding of the nonlinear dynamics of mode-locked fiber lasers.

As a type of nonlinear system with complexity, mode-locked fiber lasers are known for their complex behaviour. It is a challenging task to understand the fundamental physics behind such complex behaviour, and a unified description for the nonlinear behaviour and the systematic and quantitative analysis of the underlying mechanisms of these lasers have not been developed. Here, we present a complexity science-based theoretical framework for understanding the behaviour of mode-locked fiber lasers by going beyond reductionism.

The protective action of scutellarin against immunological liver injury induced by concanavalin A and its effect on pro-inflammatory cytokines in mice.

Scutellarin is a natural compound from a Chinese herb. The purpose of this paper was to study the protective effect of scutellarin on concanavalin A (Con A)-induced immunological liver injury and its effect on liver nuclear factor kappaB (NF-kappaB), tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), and inducible nitric oxide synthase (iNOS) expression in mice. Mouse liver injury was produced by injection of Con A 25 mg kg-1 via the tail vein.

Mechanism of protective action of bicyclol against CCl-induced liver injury in mice.

Bicyclol is a novel synthetic drug for the treatment of chronic viral hepatitis in China. This paper reports the protective action of bicyclol against experimental liver injury in mice and its mechanism of action. Oral administration of bicyclol markedly reduced the elevated serum transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and the hepatic morphologic changes induced by CCl(4) in mice.

Investigation and optimization of bidirectionally dual-order pumped distributed Raman amplifiers.

A theoretical investigation of bidirectionally dual-order pumped distributed Raman amplifiers is presented in detail, and comparisons with other Raman amplification schemes, i.e., bidirectional first-order pumping and Raman-plus-erbium-doped fiber hybrid amplification, are carried out, for the first time to the authors' knowledge, at identical nonlinear phase shifts.

Use of a genetic algorithm to optimize multistage erbium-doped fiber-amplifier systems with complex structures.

We propose optimizing multifunctional multistage erbiumdoped fiber amplifiers (EDFAs) with complex structures by use of a genetic algorithm. With this method, we investigated optimum configurations of C- and L-band gain-flattened multistage EDFAs containing gain-flattening filters and high-loss interstage elements for dense wavelength-division multiplexing systems in detail and compared the amplifiers with various kinds of configurations under different design criteria. With the guidance of optimization results, the roles of all the factors such as pumping schemes, pump-power allocation, component position, and insertion loss in the optimization of EDFAs have been studied, and useful guidelines for optimizations have been provided.