Publications by authors named "Huahua Wei"
Objective: Observational studies have revealed a link between inflammatory bowel disease (IBD) and sarcopenia. However, it remains unclear whether this correlation between IBD and sarcopenia is causal.
Methods: The genetic instrumental variables (IVs) associated with IBD and sarcopenia-related traits were derived from publicly available genome-wide association studies.
Article Synopsis
- Multiple myeloma remains an incurable disease, but advancements in treatment have extended progression-free survival for many patients, though some still experience early disease progression.
- Researchers analyzed the clinical data of 108 newly diagnosed multiple myeloma patients treated between 2015 and 2020 to identify factors involved in disease progression within the first year and developed a predictive model.
- Key predictors of progression included treatment regimens with at least two targeted drugs, increased levels of lactate dehydrogenase (LDH), and elevated serum corrected calcium, and the developed model demonstrated strong predictive capabilities to help inform personalized treatment strategies.
Objectives: Corticosteroid is first-line therapy in immune thrombocytopenia. However, nearly 30% of patients appear in steroid-resistance. Our research analyses the relevant indicators of patients and develops a risk prediction model to predict the poor response to steroid-therapy in ITP patients.
View Article and Find Full Text PDF[Increased expressions of peripheral PD-1 lymphocytes and CD4CD25FOXP3 T cells in gastric adenocarcinoma patients].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
January 2017
Article Synopsis
- The study aimed to measure the levels of PD-1 lymphocytes and CD4CD25FOXP3 regulatory T cells in patients with gastric adenocarcinoma compared to healthy individuals.
- Researchers involved 29 gastric adenocarcinoma patients and 29 matched healthy controls, using flow cytometry for detection.
- Findings revealed that both PD-1 lymphocytes and regulatory T cells were significantly higher in patients, and there was a positive correlation between PD-1 levels and regulatory T cell frequency.
Background: The performance of asthma control test (ACT) at baseline for predicting future risk of asthma exacerbation has not been previously demonstrated. This study was designed to explore the ability of the baseline ACT score to predict future risk of asthma exacerbation during a 12-month follow-up.
Methods: This post hoc analysis included data from a 12-month prospective cohort study in patients with asthma (n = 290).
[Study on the effect and mechanism of hypoxia on the histological structure of rat's lung].
Sichuan Da Xue Xue Bao Yi Xue Ban
January 2012
Unlabelled: OBJECTIVE; To observe the effect of intermittent normobaric hypoxia on the expression of transforming growth factor betal (TGF-beta1), Smad4, collagen I (Col I), tumor necrosis factor alpha (TNF-alpha) and on the changes in the histological structure of SPF SD Rat's lung.
Methods: Rats were placed in normal environment or intermittent normobaric hypoxia (101 kPa, 10% O2, 8 h every day) respectively. At the 3rd, 7th, 14th, 21st day, 5 rats from each group were killed and hematoxylin and eosin stain (HE stain) was applied to observe the pathological change in the lung of rats, immunohistochemical staining was used to detect the protein level of TGF-beta1, Col I.