Metal-free radical cascade cyclization/haloazidation of enynones to access functionalized 1-indanones.

A novel three-component radical cyclization/haloazidation of enynones, employing TMSN as the azide source and NIS (NBS or NCS) as the halogen source, has been developed under metal-free conditions for the efficient synthesis of various 1-indanones with moderate yields and acceptable / ratio. The reaction progresses through a sequence involving radical addition, 5- cyclization, and radical coupling, ultimately resulting in the formation of three new chemical bonds and a new ring in a single step. The synthetic benefits of this method have been proven by large-scale experiments and late-stage modification.

Effect of stellate ganglion injections guided by different approaches on hearing threshold in patients with sudden deafness.

Objective: The current study was conducted aimed at investigating the effect of stellate ganglion injection guided with different approaches on hearing threshold in patients harboring sudden deafness.

Methods: There involved a total of 68 patients with sudden deafness in our study. The patients were randomly allocated into control group and study group, with 34 cases in each group.

Clinical characteristics and prognosis of elderly patients with idiopathic sudden sensorineural hearing loss.

This study aimed to explore clinical characteristics and prognosis of elderly cases with sudden sensorineural hearing loss. Fifty-five elderly cases with sudden sensorineural hearing loss and 55 younger cases with sudden sensorineural hearing loss were enrolled in the study. Recovery rates of hearing between elderly group and younger group were compared.

Optimal spectra of the phosphor-coated white LEDs with excellent color rendering property and high luminous efficacy of radiation.

A model for spectra of the phosphor-coated white LED (p-W LED) with a blue chip, a red chip, and green and yellow phosphors is presented. The optimal spectra of p-W LEDs with correlated color temperatures (CCTs) of 2700-6500 K have been obtained with a nonlinear program for maximizing luminous efficacy of radiation (LER) under conditions of both color-rendering indices (CRIs) and special CRIs of R9 strong red above 98. The simulation results show that p-W LEDs with one InGaN blue (450 nm) chip, one AlGaInP red (634 nm) chip, and green (507 nm) and yellow (580 nm) silicate phosphors can realize white lights with CRIs of about 98 and special CRIs of R9 for strong red above 98.