Realization of a high-power UV-pumped optical parametric oscillator depending on the decrease of the color center density.

In this paper, a high-power UV-pumped BBO optical parametric oscillator (OPO) is presented by increasing the working temperature of the nonlinear crystal to fasten the color center recovery speed and further decrease the color center density. When the working temperature of the BBO crystal was experimentally increased from 135 °C to 185 °C, the output power was scaled up from 1.20 W to 2.

Realization of a 4 kHz, large energy single-frequency ns optical parametric oscillator by suppressing optical parametric generation.

Large energy single-frequency nanosecond (ns) near-infrared light source is an essential device in the field of the remote chemical analysis based on the laser-induced breakdown spectroscopy (LIBS). In this paper, a large energy single-frequency ns 824 nm light source with high repetition rate is presented, which is generated from a seed-injection locked optical parametric oscillator (OPO). By optimizing the spot radius of the pump laser and the mode-matching between the pump laser and signal light, the optical parametric generation (OPG) process is effectively eliminated.

SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1).

The c-Jun N-terminal kinases (JNKs) has been identified as a critical modulator in multiple cellular processes, including stress stimulus, inflammation, cell proliferation, apoptosis, etc. SP600125 is a widely used ATP-competitive reversible JNKs inhibitor. NAD(P)H: quinone oxidoreductase 1 (NQO1) is a flavoprotein mediated two or four electron-reduction of quinones.

High-power single-frequency continuous-wave 355 nm UV laser via a frequency-correlated dual-wavelength laser.

An all-solid-state single-frequency continuous-wave (CW) 355 nm ultraviolet (UV) laser based on a dispersion-compensated doubly resonant resonator is presented in this Letter that is achieved by employing homemade high-stability all-solid-state frequency-correlated dual-wavelength lasers at 1064 and 532 nm and a temperature-controlled type-I critical-phase-matching LiBO (LBO) to act as the fundamental laser source and the nonlinear medium, respectively. The frequency-correlated dual-wavelength single-frequency CW laser supplies the fundamental frequency 1064 and 532 nm lasers with good frequency synchronization. And the temperature-controlled LBO acts as the dispersion-compensation element to realize double resonance of the 1064 and 532 nm laser.

High-average-power single-frequency pulse optical parametric oscillator based on pulse-integrated seed-injection automatic locking.

Near-infrared nanosecond (ns) single-longitudinal-mode (SLM) pulse light generated from an optical parametric oscillator (OPO) is an important source in nonlinear optics and high-precision spectral analysis. In this Letter, a stable SLM near-infrared ns pulse light source generated from the OPO is presented, which is achieved by developing a seed-injection automatic locking technique based on a pulse-integrated photodetector (PIPD). Depending on the PIPD, the peak power of the pulse light detected by the photodiode is converted to the average power by integrating several pulses.

208 W single-frequency 1064 nm laser based on a single-crystal fiber master-oscillator power amplifier.

High-power all-solid-state continuous-wave (CW) single-frequency laser with high linear polarization is a significant source for quantum optics and precision measurement. In this Letter, a high-power linearly polarized CW single-frequency laser based on the single-crystal fiber (SCF) master-oscillator power amplifier (MOPA) is presented, in which a homemade 140 W low-noise CW single-frequency laser and a Nd:YAG SCF are firstly employed as the seed laser and the medium of the MOPA, respectively. The mode-matching between the pump laser propagated with waveguide form and the freely propagated seed laser is optimized by considering the influence of the degradations of the polarization and the beam quality.

Umbilical cord MSC-derived exosomes improve alveolar macrophage function and reduce LPS-induced acute lung injury.

Acute lung injury (ALI) is a severe condition that can progress to acute respiratory distress syndrome (ARDS), with a high mortality rate. Currently, no specific and compelling drug treatment plan exists. Mesenchymal stem cells (MSCs) have shown promising results in preclinical and clinical studies as a potential treatment for ALI and other lung-related conditions due to their immunomodulatory properties and ability to regenerate various cell types.

Auto-pump-depleted stable single-longitudinal-mode 1.5 μm source with the assistance of SHG.

To realize a stable single-longitudinal-mode (SLM) 1550-nm light source for the generation of non-classical states, a ring auto-pump-depleted singly resonant optical parametric oscillator (SRO) with the assistance of second-harmonic-wave generation (SHG) is designed and built in this Letter. A magnesium oxide doped periodically polarized lithium niobate (MgO:PPLN) crystal and a lithium triborate (LBO) crystal are employed as the optical parametric downconversion (OPDC) and SHG crystals, respectively. Especially, the introduced SHG can firstly increase the loss difference between the lasing and non-lasing modes so that the dual-mode or multi-mode coupling in the achieved SRO can be effectively eliminated and the stable SLM operation is achieved.

Fecal microbiota transplantation from HUC-MSC-treated mice alleviates acute lung injury in mice through anti-inflammation and gut microbiota modulation.

Introduction: Acute lung injury (ALI) is a severe respiratory tract disorder facilitated by dysregulated inflammation, oxidative stress and intestinal ecosystem. Fecal microbiota transplantation (FMT) is a rapid method for gut microbiota (GM) reconstruction. Furthermore, our previous studies have confirmed that human umbilical cord mesenchymal stromal cells (HUC-MSCs) can alleviate ALI by improving GM composition.

High-average-power single-longitudinal-mode pulse laser based on a pulse saturation seed-injection locking OPO.

A high-average-power and narrow-linewidth nanosecond (ns) pulse 824 nm laser is a crucial source for the generation of deep-ultraviolet (DUV) 248 nm laser by means of the sum-frequency process with the 354.5 nm laser. To this purpose, in this Letter, we present a seed-injection-locked high-average-power ns pulse single-longitudinal-mode (SLM) 824 nm laser.

Prognostic significance of CDK6 amplification in esophageal squamous cell carcinoma.

Dysregulation of CDK6 plays crucial roles in the carcinogenesis of many kinds of human malignancies. However, the role of CDK6 in esophageal squamous cell carcinoma (ESCC) is not well known. We investigated the frequency and prognostic value of CDK6 amplification to improve the risk stratification in patients with ESCC.

TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway.

Introduction: Thyroid cancer has received increasing attention; however, its detailed pathogenesis and pathological processes remain unclear. We investigated the role of TANK-binding kinase 1 (TBK1) in the progression of thyroid cancer.

Methods: The expression of TBK1 in thyroid cancer and normal control tissues was analyzed using real-time quantitative polymerase chain reaction.

Self-mode-matching compact low-noise all-solid-state continuous wave single-frequency laser with output power of 140 W.

The high power all-solid-state continuous wave single-frequency laser is a significant source for science and application due to good beam quality and low noise. However, the output power of the laser is usually restricted by the harmful thermal lens effect of the solid gain medium. To address this issue, we develop a self-mode-matching compact all-solid-state laser with a symmetrical ring resonator in which four end-pumped Nd:YVO laser crystals are used for both laser gain media and mode-matching elements.

Clinical features of psittacosis in 46 Chinese patients.

Background: Psittacosis is a relatively uncommon cause of community-acquired pneumonia, often leading to diagnostic difficulty.

Methods: A retrospective study was conducted on the clinical features of psittacosis patients in China. Forty-six cases of Chlamydophila psittaci infection with atypical pneumonia of varying severity in the last two years were described retrospectively.

Realization of CW single-frequency tunable Ti:sapphire laser with immunity to the noise of the pump source.

All-solid-state continuous-wave (CW) single-frequency tunable Ti:sapphire (Ti:S) laser is an important source in quantum optics and atomic physics. However, intracavity etalon (IE) locking is easily influenced by the intensity noise of the pump source in the low frequency band. In order to address this issue, a differential detector with dual-photodiodes (PDs) is designed and employed in the experiment.

Optimization of the nonlinear crystal length for high-power single-frequency intracavity frequency-doubling lasers.

We report a method of optimizing the nonlinear crystal length of the intracavity frequency-doubling laser, which is achieved by maximizing the output power of the frequency-doubling laser in the case of ensuring the single longitudinal mode (SLM) operation of the laser. The optimal length of the nonlinear crystal for an SLM oscillation of the intracavity frequency-doubling laser is firstly theoretically predicted by comparing the losses introduced by the nonlinear crystal with different lengths with that of ensuring the SLM operation of the laser. Then three nonlinear (LBO) crystals with the length of 18, 20, and 22 mm are adopted to be the frequency-doubling components in the experiment.

Performance Improvement of Single-Frequency CW Laser Using a Temperature Controller Based on Machine Learning.

The performance improvement of an all-solid-state single-frequency continuous-wave (CW) laser with high output power is presented in this paper, which is implemented by employing a temperature control system based on machine learning to control the temperature of laser elements including gain crystal, laser diode and so on. Because the developed temperature controller based on machine learning combines the back propagation (BP) neural network algorithm with the proportion-integration-differentiation (PID) control algorithm, the parameters of the PID are adaptive with the variation of the environment. As a result, the control speeds and control abilities of the temperatures of the elements are dramatically enhanced.

Kikuchi-Fujimoto disease following vaccination against COVID-19.

The purpose of this study is to explore the clinicopathological features of Kikuchi-Fujimoto disease (KFD) following vaccination against coronavirus disease 2019 (COVID-19). One case of KFD following vaccination against COVID-19 was examined clinically, histologically, and immunohistochemically. The patient was a 36-year-old Chinese man who suffered from fever and cervical lymph node swelling following simultaneous administration of the COVID-19 vaccine.

In Situ Assembly of Ordered Hierarchical CuO Microhemisphere Nanowire Arrays for High-Performance Bifunctional Sensing Applications.

Seeking a facile approach to directly assemble bridged metal oxide nanowires on substrates with predefined electrodes without the need for complex postsynthesis alignment and/or device procedures will bridge the gap between fundamental research and practical applications for diverse biochemical sensing, electronic, optoelectronic, and energy storage devices. Herein, regularly bridged CuO microhemisphere nanowire arrays (RB-MNAs) are rationally designed on indium tin oxide electrodes via thermal oxidation of ordered Cu microhemisphere arrays obtained by solid-state dewetting of patterned Ag/Cu/Ag films. Both the position and spacing of CuO microhemisphere nanowires can be well controlled by as-used shadow mask and the thickness of Cu film, which allows homogeneous manipulation of the bridging of adjacent nanowires grown from neighboring CuO hemispheres, and thus benefits highly sensitive trimethylamine (TMA) sensors and broad band (UV-visible to infrared) photodetectors.

A Review of the High-Power All-Solid-State Single-Frequency Continuous-Wave Laser.

High-power all-solid-state single-frequency continuous-wave (CW) lasers have been applied in basic research such as atomic physics, precision measurement, radar and laser guidance, as well as defense and military fields owing to their intrinsic advantages of high beam quality, low noise, narrow linewidth, and high coherence. With the rapid developments of sciences and technologies, the traditional single-frequency lasers cannot meet the development needs of emerging science and technology such as quantum technology, quantum measurement and quantum optics. After long-term efforts and technical research, a novel theory and technology was proposed and developed for improving the whole performance of high-power all-solid-state single-frequency CW lasers, which was implemented by actively introducing a nonlinear optical loss and controlling the stimulated emission rate (SER) in the laser resonator.

Alterations of coagulation and fibrinolysis in patients with blunt splenic injury after splenic artery embolization.

Background: Thrombotic complications following splenectomy have been documented. However, there has been sparse literature regarding thrombotic complications following splenic artery embolization (SAE).The objective of this study was to determine changes in coagulation and fibrinolysis and assess the thrombotic risk after SAE in patients with blunt splenic injury (BSI).

Realization of compact Watt-level single-frequency continuous-wave self-tuning titanium: sapphire laser.

Here, we present a compact Watt-level single-frequency continuous-wave (CW) self-tuning titanium:sapphire (Ti:S) laser, which is implemented using a three-plate Ti:S crystal as both a gain medium and frequency-tuning element. The thickness ratio of the three-plate Ti:S crystal is 1:2:4, of which the thinnest plate measured 1 mm. The optical axes lie on their own surfaces and parallel to each other.

Diving angle optimization of BRF in a single-frequency continuous-wave wideband tunable titanium:sapphire laser.

In this study, the optimal condition of a multi-plate birefringent filter (BRF) used in a single-frequency continuous-wave (CW) tunable laser is theoretically and experimentally investigated. The dependence of the optimal condition on the diving angle of the BRF optical axis is first deduced. Based on the proposed optimal condition, the diving angle of the BRF optical axis is optimized to 29.

Intensity noise suppression of a high-power single-frequency CW laser by controlling the stimulated emission rate.

The intensity noise of a high-power single-frequency continuous-wave (CW) laser is very harmful for applications in precise measurements and quantum communication. By simply lengthening the length of a laser resonator to decrease the stimulated emission rate of the laser, the coupling strength of all noise sources in the resonant laser field will be reduced, and thus the intensity noise of the output laser will be prominently suppressed. Based on theoretical analyses of the laser noise spectra, we experimentally implement a low-noise high-power single-frequency laser with a 1050 mm long resonator.