Enhanced brightness and photostability of dye-sensitized Nd-doped rare earth nanocomposite for in vivo NIR-IIb vascular and orthotopic tumor imaging.

Rare-earth doped nanoparticles (RENPs) have shown promise in biomedical imaging, particularly within the NIR-IIb region, due to their deep tissue penetration and minimal light scattering. However, challenges such as low extinction coefficients, narrow excitation spectra, and prone to quenching in aqueous environments limit their effectiveness. To overcome these obstacles, we developed a novel dye-sensitized, onion-like Nd-doped RENP nanocomposite to enhance NIR-IIb imaging performance.

Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated patients.

Background: This single-arm phase II trial aimed to assess the effectiveness and safety of incorporating hyperthermia into salvage concurrent chemoradiotherapy (CCRT) for previously irradiated unresectable recurrent head and neck cancer.

Methods: We enrolled patients with non-metastatic recurrent head and neck cancer who had previously undergone radiotherapy (RT) and were unfit for salvage surgery. Eligible patients received hyperthermia during salvage CCRT.

An impermeable copper surface monolayer with high-temperature oxidation resistance.

Despite numerous efforts involving surface coating, doping, and alloying, maintaining surface stability of metal at high temperatures without compromising intrinsic properties has remained challenging. Here, we present a pragmatic method to address the accelerated oxidation of Cu, Ni, and Fe at temperatures exceeding 200 °C. Inspired by the concept that oxygen (O) itself can effectively obstruct the pathway of O infiltration, this study proposes the immobilization of O on the metal surface.

Investigation of common and unreported parabens alongside other plastic-related contaminants in human milk using non-targeted strategies.

Human milk studies analyzing widely used contaminants mainly utilize a targeted approach to screen and quantify a limited number of compounds. While targeted analysis allows health officials to quantify the levels of these chemicals in human milk, it fails to detect the presence of other unknowns that may be of equal importance. Hence, the objective of this study was to apply non-targeted analysis to detect and identify different prevalent contaminants, specifically common or unreported parabens as well as other plastic-related contaminants (PRCs) in human milk.

Relationship between prenatal metals exposure and neurodevelopment in one-year-old infants in the CLIMB study.

Background: Prenatal metals exposure and its effects on infant neurodevelopment have garnered significant attention. However, most studies focus on individual metals, neglecting combined effects.

Objectives: We aimed to assess the effects of both single and combined prenatal metals exposure on one-year-old infants' neurodevelopment.

Hydroxytyrosol downregulates inflammatory responses via Nrf2/HO-1 axis during fungal keratitis and exerts antifungal effects.

Purpose: This study aims to explore the protective effect and underlying mechanism of hydroxytyrosol (HT) in fungal keratitis.

Methods: Mouse models with Aspergillus fumigatus (A. fumigatus) keratitis, human corneal epithelial cells (HCECs) and RAW 264.

Insights into the gut microbiota characteristics between the organic and traditional feeding chickens based on amplicon and metagenomic sequencing.

Intestinal microorganisms play a crucial role in chicken health and production performance, especially in the research of traditional and organic feeding methods. The intestinal contents of organic and feed chickens were analyzed by 16S rRNA gene and metagenome technology. The results showed that the microbial diversity of organic chickens was significantly higher than that of the feed chickens, especially the key microorganisms, such as , were more abundant in organic chickens.

Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure.

Background: Infection after craniocerebral operation has always been a very focused problem, and dural closure can reduce perioperative infection by reducing drainage volume and subcutaneous effusion, so how to effectively perform dural closure seems to be a small but not negligible problem.

Methods: We proposed a classification and grading system for dural incisions based on the type and degree of suture, and based on the system, a standardized operation process for ADS (absorbable dural sealant) was developed. Then, we conducted a retrospective study.

A case report of confirmed difficult pulmonary tuberculosis based on the hybrid capture-based tNGS method.

Background: Early diagnosis of pulmonary tuberculosis can greatly reduce the harm caused by the disease. However, traditional diagnostic methods have various shortcomings in diagnosing pulmonary tuberculosis. Currently, with the increasing popularity, iteration, and decreasing costs of Next-generation sequencing (NGS) testing technology, NGS is being more widely applied in the diagnosis of pulmonary tuberculosis.

Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis.

Background: Patients with cryptogenic stroke or embolic stroke of undetermined source (ESUS) face a high risk of recurrent ischaemic stroke, but the optimal antithrombotic strategy remains unclear. This systematic review and meta-analysis compared the effectiveness and safety of oral anticoagulants (OACs) versus antiplatelets in these populations, with a focus on subgroup effects by key clinical characteristics.

Methods: Six databases were searched through March 2024 to identify randomised controlled trials (RCTs) comparing OACs and antiplatelets in patients with cryptogenic stroke or ESUS.

Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights.

Background: OH2 is an oncolytic virus derived from herpes simplex virus type 2. A phase Ia/Ib clinical trial in China was conducted in patients with unresected stage III-IV melanoma, the majority of whom had the acral type, to assess the safety and preliminary efficacy of OH2.

Methods: The trial enrolled patients with histologically confirmed unresectable stage III or advanced stage IV melanoma.

Hybrid crosslinking cellulose nanofibers-reinforced zwitterionic poly (ionic liquid) organohydrogel with high-stretchable, anti-freezing, anti-drying as strain sensor application.

Conductive hydrogels (CHs) have demonstrated great potential application in wearable devices as a substitute for traditional rigid metal electrode sensors. However, the design of CHs with excellent mechanical stability for extreme environmental conditions remains a great challenge due to the high water content present in hydrogels. Herein, a novel anti-freezing and anti-drying zwitterionic poly (ionic liquid) organohydrogel was prepared via free-radical polymerization of acrylic acid (AA), 1-propyl-3-vinyl imidazole sulfonate (ZILs), cellulose nanofibers (CNFs) and ferric chloride (FeCl) in a glycerol/water mixture solvent.

Achieving High Quality Factor Interband Nanoplasmonics in the Deep Ultraviolet Spectrum via Mode Hybridization.

Interband plasmons (IBPs) enable plasmonic behavior in nonmetallic materials, such as semiconductors. Originating from interband electronic transitions, IBPs are characterized by negative real permittivity that can extend into deep ultraviolet (DUV) spectrum, as demonstrated using silicon. However, the practical applications of IBPs are limited by their inherently broad resonances.

Shaker/Kv1 potassium channel SHK-1 protects against pathogen infection and oxidative stress in C. elegans.

The Shaker/Kv1 subfamily of voltage-gated potassium (K+) channels is essential for modulating membrane excitability. Their loss results in prolonged depolarization and excessive calcium influx. These channels have also been implicated in a variety of other cellular processes, but the underlying mechanisms remain poorly understood.

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2).

Purpose: Allograft rejection remains a major cause of failure in high-risk corneal transplants, but the underlying mechanisms are not fully understood. This study aimed to investigate the contribution of transplantation stress-induced cellular senescence to corneal allograft rejection and to elucidate the associated molecular mechanisms.

Methods: Age-matched murine corneal transplantation models were established.

Intravenous thrombolysis prevents neurological deterioration in patients with acute pontine infarction.

Objectives: Neurological deterioration (ND) is common after acute isolated pontine infarction, and no evidence-based treatment is available to prevent this. We determined whether intravenous thrombolysis (IVT) with tissue plasminogen activator soon after pontine infarction prevents ND.

Methods: We retrospectively enrolled consecutive patients admitted to our hospital within 4.

CKD patients comorbid with hypertension are associated with imbalanced gut microbiome.

Intestinal flora has been linked to chronic kidney disease (CKD) and hypertension, respectively. This study aimed to investigate the microbial community among 54 individuals without CKD, 46 hypertensive CKD patients (CKD_HTN), and 48 non-hypertensive CKD patients. Variations in microbial diversity were detected in CKD.

Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial.

This prospective, nonrandomized, open-label phase 2 trial (Chinese Clinical Trial Registry, ChiCTR2200061906) aimed to evaluate the effectiveness of adding the PD-1 antibody tislelizumab to perioperative chemotherapy in patients with locally advanced gastroesophageal junction adenocarcinoma (GEJA). This study enrolled patients with GEJA clinically staged as cT3-4aNanyM0 or cT1-2N+M0 from October 2022 to June 2023. Eligible patients were administered three preoperative and five postoperative 3-week cycles of treatment with PD-1 antibody tislelizumab plus SOX (S-1 and oxaliplatin) regimen.

Chemical components of Salvia cavaleriei and their anti-inflammatory effect via NF-κB signaling pathway.

In this study, with the aimed to explore the anti-inflammatory ingredients of Salvia cavaleriei, a phytochemical study with bioactive guided isolation for this plant have been taken. As a result, two pairs of new phenylacetic acid enantiomers, (±) cavalvia A (±1) and B (±2), and one previously undescribed germacrane-type sesquiterpenoid, salviesquiten A (3), along with ten known ones (4-13) were isolated from the ethyl acetate portion of 95 % ethanol extract. Their chemical structures were established based on UV, IR, MS and NMR spectroscopic analyses, as well as PD4 probability analysis and electronic circular dichroism (ECD) methods.

Protective effects of CoQ10 and L-carnitine against antidepressant-induced mitochondrial dysfunction and teratogenicity in chicken embryos.

Fluoxetine (FXT) and alprazolam (APZ), widely used for mental disorders, have poorly studied adverse effects on mitochondrial function, including oxidative phosphorylation, electron transport, and membrane permeability. This study represents the first investigation using a chick embryo model (HH-stage 10, day 1.5) to analyze the teratogenic effects of FXT and APZ and explore the protective potential of coenzyme Q10 (CoQ10) and L-carnitine (CNT).

Glucagon-Like Peptide 1 Receptor Agonists and Venous Thromboembolism in Type 2 Diabetes: A Target Trial Emulation.

Glucagon-like peptide 1 receptor agonists (GLP1-RA) are anti-diabetes agents recently approved for weight loss. Obesity is an established risk factor for venous thromboembolism (VTE). Moreover, preclinical studies have shown that GLP1-RA may attenuate thromboxaneinduced platelet activation.

Research status and application scenarios of 3D human body modelling methods in the garment ergonomics: a systematic review.

This research aims to enhance the comprehension of 3D human modelling methodologies pertinent to the garment ergonomics field. Through a search and analysis of 442 literatures, this study found that, despite the utilisation of high-resolution scanning and sophisticated 3D software, generating the vast diversity of human physiques in models remains a formidable challenge, attributed to issues such as data discrepancies and loss of detail from self-occlusion. Furthermore, through an exhaustive literature survey, this research formulates a framework for juxtaposing various modelling methodologies, analysing their technical tenets, benefits, and limitations from a synergetic and iterative standpoint.

Development and validation of long-acting recombinant human TSH using SAFA technology.

Thyrogen, a recombinant human thyroid-stimulating hormone (rhTSH), has a short half-life in the bloodstream, which necessitates multiple doses during treatment. Therefore, we developed a new long-acting rhTSH using anti-serum albumin Fab-associated (SAFA) technology to validate its biological activity through in vitro assays, pharmacokinetic studies in healthy mice and pharmacodynamics studies in a thyroid-stimulating hormone (TSH)-suppressed mouse model. SAFA-TSH was produced using a Chinese hamster ovary expression system.

Evaluation of health care providers' ability to identify patient-ventilator triggering asynchrony in intensive care unit: a translational observational study in China.

Background: Patient-ventilator asynchrony (PVA) can result in ventilator-induced lung injury (VILI), prolong mechanical ventilation, and ventilator withdrawal failure. The ability of healthcare providers in China to recognize patient-ventilator asynchrony is unknown. The aim of our study was to evaluate the ability and potential influencing factors to correctly identify patient-ventilator triggering asynchrony in tertiary hospitals in China.

Identifying CSNK1E as a therapeutic target in thyroid cancer among the core circadian clock genes.

Previous studies have shown that thyroid malignancies can alter the transcriptional oscillations of circadian clock genes. In this study, we screened the expression of core circadian clock genes in thyroid neoplasms and found that CSNK1E, NPAS2, and TIMELESS were upregulated, while ARNTL, CRY1, CRY2, PER2, and RORA were downregulated during the progression and dedifferentiation of thyroid cancer. Immunohistochemical analysis further confirmed an increase in CSNK1E expression parallel to the loss of tumor differentiation.