Effectiveness of Grief Camps in Supporting Bereaved Individuals: A Systematic Review.

Experiencing the death of a loved one is a stressful and disruptive event that can have short-term and long-term detrimental effects on the grief, mental health, and social functioning of the bereaved individuals. Grief camps represent a relatively novel form of support. However, little is known about their effectiveness.

Photocatalytic Degradation of Ciprofloxacin by GO/ZnO/Ag Composite Materials.

This study synthesized graphene oxide (GO)/zinc oxide (ZnO)/silver (Ag) composite materials and investigated their photocatalytic degradation performance for ciprofloxacin (CIP) under visible light irradiation. GO/ZnO/Ag composites with different ratios were prepared via an impregnation and chemical reduction method and characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). The results demonstrated that under optimal conditions (20 mg/L CIP concentration, 15 mg catalyst dosage, GO/ZnO-3%/Ag-doping ratio, and pH 5), the GO/ZnO/Ag composite exhibited the highest photocatalytic activity, achieving a maximum degradation rate of 82.

Mechanism Study of Bufalin Reversal of Drug Resistance by Inhibiting Hypoxic Colon Cancer Cell-Induced Polarization of M2 Macrophages.

Chemoresistance is still an important factor affecting the efficacy of treatment in colorectal cancer (CRC) patients. Hypoxia is related to poor prognosis and treatment resistance in cancer. Relevant studies have shown that a hypoxic microenvironment can promote the polarization of M2 macrophages and thus promote tumor development.

SATB1 in cancer progression and metastasis: mechanisms and therapeutic potential.

Cancer remains a major global health challenge, with prostate cancer, lung cancer, colorectal cancer, and breast cancer accounting for nearly half of all diagnoses. Despite advancements in cancer treatment, metastasis to distant organs continues to be the leading cause of cancer-related mortality. The progression of cancer involves the alteration of numerous genes, with dynamic changes in chromatin organization and histone modifications playing a critical role in regulating cancer-associated genes.

The impact of frequency-specific music stimulation on consciousness in patients with disorders of consciousness.

Objective: This study aimed to evaluate the effects of frequency-specific music stimulation on the awareness and brain connectivity in patients with disorders of consciousness (DOC).

Methods: A total of 25 DOC patients were exposed to auditory stimulation through music at varying frequencies (low: <0.5 Hz, middle: 0.

Alleviation of salt stress in strawberries by hydrogen-rich water: Physiological, transcriptomic and metabolomic responses.

The increasing impacts of climate change and intensified human activities exacerbate soil salinization, posing significant challenges to agricultural productivity. Therefore, addressing salt stress in crops is a critical area of research. In this study, strawberry seedlings (Fragaria×ananassa Duch.

Hormone correction of dysfunctional metabolic gene expression in stem cell-derived liver tissue.

The increase in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to metabolic dysfunction-associated steatohepatitis (MASH) is a worldwide healthcare challenge. Heterogeneity between men and women in the prevalence and mechanisms of MASLD and MASH is related to differential sex hormone signalling within the liver, and declining hormone levels during aging. In this study we used biochemically characterised pluripotent stem cell derived 3D liver spheres to model the protective effects of testosterone and estrogen signalling on metabolic liver disease 'in the dish'.

Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis.

Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in mice of both sexes.

Prevalence, microbiology, and outcome of peritonitis in peritoneal dialysis patients in vietnam: a multicenter study.

Background: Chronic kidney disease (CKD) is a substantial contributor to global mortality, requiring interventions like kidney transplantation and dialysis. Peritoneal dialysis (PD) has emerged as an effective dialytic modality despite the susceptibility to peritonitis. The study aimed to determine the prevalence of peritonitis among PD patients, elucidating pivotal factors affecting its occurrence, causative bacterial agents, and treatment outcomes (mortality rates, removal of the Tenckhoff catheter, and switch to hemodialysis).

The Effect of Medialization Procedures on Laryngopharyngeal Reflux in Patients With Glottic Insufficiency: A Preliminary Study.

Objective: To evaluate whether medialization procedures performed for management of glottic insufficiency also reduce patients' concurrent laryngopharyngeal reflux (LPR) signs.

Study Design: Retrospective chart review.

Methods: A retrospective chart review was conducted of patients who visited the office of the senior author, received a diagnosis of glottic insufficiency and LPR, and were offered medialization procedures.

Fibrosis in Distal Rectum of Anorectal Malformation: A Clinicopathological Study.

Background: The distal rectum may have neuromuscular system abnormalities, which could be the causes of constipation of anorectal malformations (ARMs). This study aimed to characterize fibrosis in the distal rectum. To propose new hypotheses for the mechanism of constipation and provide histopathological evidence for the distal rectum resection during anorectoplasty.

The effects of sika deer oviduct epithelial cell-derived extracellular vesicles on oocytes and parthenogenetic embryos.

Oviducts contain various nutrients that provide energy during oocyte development. This study aimed to improve the efficiency of in vitro reproduction using extracellular vesicles (EVs) produced by the oviduct epithelial cells of sika deer (Cervus nippon). Surprisingly, the uptake of deer oviduct epithelial cell extracellular vesicles (DOEC-EVs) by cumulus-oocyte complexes, which were encapsulated by dense cumulus cells (CCs), occurred only in CCs during maturation.

Chain length of fatty acid determines the reassembly behaviors of starch-lipid complexes following microwave heat-moisture treatment.

Food postprocessing can induce the structural changes of starch-lipid complexes, however, how the chain length of fatty acids affects their reassembly behaviors during postprocessing has not been researched. Accordingly, starch-lipid complexes containing varying chain lengths of fatty acids were prepared and the changes in their structures and digestibility were investigated during microwave heat-moisture treatment. After treatment, the contents of complexed lipids, complex index, and single helix in the complexes increased, and the values were lower for complexes containing longer-chain fatty acids.

Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.

Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), poses a serious threat to global health. Aseptic inflammation and pyroptosis of podocytes are crucial factors contributing to the pathogenesis and progression of DKD. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a novel class of antidiabetic agents widely used in clinical settings, may exert a protective effect on podocyte injury, although the underlying mechanisms remain poorly understood.

Iridium(III) Carbene Complexes Featuring either Metal-to-Ligand Charge Transfer (MLCT) or Through-Space Charge Transfer (TSCT) Blue Luminescence.

Through-space charge transfer (TSCT) rather than the commonly postulated metal-to-ligand charge transfer (MLCT) process was proposed in getting the lowest lying excited state of newly designed Ir(III) blue phosphors. Accordingly, two benzo[d]imidazolylidene pro-chelates L12H2+ and L13H2+, one with two cyano groups at the peri-benzo and N-aryl pendent and the other with its peri-cyano group being replaced with methyl substituent, were employed in syntheses of Ir(III) complexes f-ct12b,c and f-ct13b,c. Notably, complexes f-ct12b,c exhibited the traditional MLCT process, while f-ct13b,c were dominated by the TSCT transition, resulting in a smaller S1-T1 energy gap ΔEST.

Genetic Analysis of Fetal Growth Restriction Caused by Rare 4q28.1q31.21 Microdeletion.

Background: This study conducted genetic analysis on fetuses indicated to be at high risk by non-invasive prenatal testing (NIPT) to explore the etiology.

Methods: Karyotype analysis and single nucleotide polymorphism array (SNP-array) were performed to detect copy number variations in fetal amniotic fluid and parental peripheral blood.

Results: Fetal karyotype showed 46, X?, del (4) (q28q31.

Outcomes and risk factors for functional prognosis at 3 months after intravenous thrombolysis with r-tPA in patients with acute ischemic stroke: a retrospective cohort study.

Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the preferred treatment for acute ischemic stroke (AIS). Nevertheless, only approximately half of patients undergoing IVT experience positive outcomes. The objective of the study was to examine the clinical characteristics of patients with AIS and identify predictors for unfavorable clinical outcomes at 3 months after IVT.

Three-dimensional and magnified CT images of displaying the imaging features of invasive adenocarcinoma of lung.

Objective: To discuss CT imaging characteristics of invasive adenocarcinoma of lung(IACL).

Methods: CT revealed the nodule of lung which pathology confirmed as IACL of 290 cases. Imaging data were retrospectively analyzed by dividing into high-risk group of 115 cases and low-risk group of 175.

The effects of China-recommended gestational weight gain guidelines and the Institute of Medicine guidelines on adverse birth outcomes: A population- based cohort study.

Objectives: This study aimed to assess and compare the Institute of Medicine (IOM) guidelines and the recently published China guidelines regarding their applicability for gestational weight gain (GWG) management among Chinese pregnant women.

Method: Data were extracted from the Electronic Medical Record System of Zhoushan, China. Adverse outcomes include small for gestational age (SGA), large for gestational age (LGA), low birth weight and macrosomia.

Edge-guided inverse design of digital metamaterial-based mode multiplexers for high-capacity multi-dimensional optical interconnect.

The escalating demands of compute-intensive applications urgently necessitate the adoption of optical interconnect technologies to overcome bottlenecks in scaling computing systems. This requires fully exploiting the inherent parallelism of light across scalable dimensions for data loading. Here we experimentally demonstrate a synergy of wavelength- and mode- multiplexing combined with high-order modulation formats to achieve multi-tens-of-terabits-per-second optical interconnects using foundry-compatible silicon photonic circuits.

SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines.

Background And Purpose: Sphingosine-1-phosphate (S1P)/S1P receptor signalling exerts cardioprotective effects. However, the effect of the selective S1P receptor agonist SEW2871 on myocyte necroptosis in heart failure and the underlying mechanisms are unknown. In the present study, we tested the hypothesis that SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines.

Impact of renal artery stenosis on renovascular hypertension and the therapeutic role of renal artery stenting: a comprehensive review.

Background Renal artery stenosis (RAS) is characterized by reduced renal perfusion, activating the renin-angiotensin-aldosterone system (RAAS), which can lead to secondary hypertension, ischemic nephropathy, and cardiac destabilization syndrome. These conditions have significant healthcare implications. Renovascular hypertension (RVH) in RAS patients can be managed through medical therapy and revascularization, either endovascular or surgical.

Purification of solid waste phosphogypsum by various cationic collectors: Experimental study and theoretical calculation.

Phosphogypsum (PG), a byproduct of phosphate fertilizer production, poses environmental pollution risks due to the potential release of impurities such as phosphorus, fluoride, and organic compounds, necessitating effective treatment and remediation. Among various methodologies, flotation has emerged as a key technique for separating impurities from PG. Although extensive research has been conducted on the separation and reuse of PG, studies focusing specifically on organic impurity separation and collector optimization are still limited.

High expression of stearoyl-coenzyme A desaturase in colorectal cancer oncogenic functions and its potential as a therapeutic target.

Background: The stearoyl-coenzyme A desaturase () gene influences colorectal cancer (CRC) pathogenesis, with its expression linked to tumor cell survival and resistance, necessitating further investigation into its role in CRC.

Aim: To explore the clinical and pathological significance of SCD expression in CRC tissues and to evaluate the affinity between nitidine chloride (NC) and SCD as a target.

Methods: Multi-center high-throughput data related to CRC were integrated to calculate the standardized mean difference of mRNA expression levels.

Implementation of antepartum preterm birth interventions: A scoping review.

While antenatal recommendations regarding preterm birth are essential to preventing neonatal morbidity and mortality, implementation of these recommendations underscore how health system capacity and systemic factors, such as access and quality, greatly influence their utilization. To date, there is limited synthesis focused on the implementation of antenatal preterm birth interventions. Our objectives were to focus on implementation science studies intended to 1) increase referral mechanisms of pregnant people to higher levels of care where the management of preterm labor or delivery is possible and 2) map the implementation of preterm birth interventions, including the administration of antenatal corticosteroids, magnesium sulfate, and antibiotics.