Establishing Personalized and Sparse Spinal Reflex Circuitry from Locomotion Data.

Spinal reflex circuitry-based controllers have shown promising capabilities in controlling the biomechanics of locomotion in simulation. Studies have been done to tune or identify reflex circuitry from imposed objectives, such as metabolic energy efficiency, maintaining balance or mimicking experimental data. However, in those works, the reflex structure was predefined by the authors.

Ionic liquid introduced NH-MIL-53(Al) mixed matrix membrane coupled with UPLC-MS/MS for the simultaneous determination of neonicotinoid insecticides and their metabolites in different samples.

In this study, a novel hydroxyl-functionalized imidazolium-based ionic liquid introduced metal-organic framework (OH-IL@NH-MIL-53(Al)) was prepared for the extraction of multiple neonicotinoids (NEOs) and their metabolites. The functionalization of ionic liquid obviously enhanced the generate affinity of OH-IL@NH-MIL-53(Al) towards NEOs and their metabolites through the pre-designed hydrogen-bonding and cation-π electron donor-acceptor interactions. Adsorption studies of OH-IL@NH-MIL-53(Al) showed rapid adsorption rates and excellent adsorption capacities (129.

Low temperature storage leads to advanced upregulation of typical virulence regulators, pyk and purR of enterotoxigenic Staphylococcus aureus cultured on chicken meat.

Staphylococcal enterotoxins have long been studied due to the food-borne illness caused and complex intracellular virulence regulation involved. Along with the popularized application of cold chain production of meat products, there is important significance to explore the influence of low temperature on enterotoxin genes expression correlated to regulators under meat cultivation. In this study, SEA and SEB type Staphylococcus aureus strains (designated Sa08 and Sa13 respectively) were cultivated on chicken meat at 8 and 25 °C, typical virulence regulators (agrA, saeS, srrB, rot, codY and icaA), enterotoxins (sea and seb) and metabolic factors (pyk and pyruvate, purR and xanthosine monophosphate) were monitored.

Cannabidiol alleviates the inflammatory response in rats with traumatic brain injury through the PGE -EP2-cAMP-PKA signaling pathway.

Traumatic brain injury (TBI) is a recognized global public health problem. However, there are still limitations in the available therapeutic approaches and a lack of clinically effective drugs. Therefore, an in-depth exploration of the secondary pathological mechanism of TBI and the identification of new effective drugs are urgently needed.

Impact of C/N/P dietary nutrient on manure characteristics: Pollutant fractions and microbial community.

Regulation of labile fraction of excreted manure represents a promising advance for environmental pollution mitigation. However, investigation of the properties of various pollutant fractions within manure and potential influence of dietary nutrient fractions on the release of labile manure remains unclear. Feeding trials involving pigs at three distinct growth stages fed by diets with nine different energy levels were conducted and the characteristics of labile manure generated under various treatments based on nutrient profiles were analyzed.

Clinical value of quantitative echocardiographic features in preterm infants with necrotizing enterocolitis.

This study investigated the correlation between quantitative echocardiographic characteristics within 3 days of birth and necrotizing enterocolitis (NEC) and its severity in preterm infants. A retrospective study was conducted on 168 preterm infants with a gestational age of < 34 weeks. Patients were categorized into NEC and non-NEC groups.

In Silico Exploration of Staphylococcal Cassette Chromosome (SCC) Evolution Based on Phylogenetic Relationship of .

As the mobile cassette carrier of the methicillin resistance gene that is transported across staphylococci species, the evolution and origin of Staphylococcal Cassette Chromosome (SCC)-and in particular, the composition of and SCC-have been extensively discussed in the scientific literature; however, information regarding its dissemination across geographical limits and evolution over decades remains limited. In addition, whole-genome sequencing-based macro-analysis was unable to provide sufficiently detailed evolutionary information on SCC. Herein, the cassette chromosome recombinase genes , as essential components of SCC, were employed to explore the evolution of SCC.

B cell translocation gene 2 expression levels in human granulosa cells is negatively associated with in vitro fertilization/intracytoplasmic sperm injection outcomes: a pilot study.

Purpose: This study aimed to monitor the expression of B-cell translocation gene 2 (BTG2) in granulosa cells of patients undergoing IVF/ICSI with respect blastocyst quality outcomes.

Methods: We recruited 181 women undergoing IVF/ICSI cycles for infertility. Granulosa cells were extracted from follicular fluid.

Humanin alone and in combination with GnRHa therapy attenuates ovarian dysfunction induced by prepubertal cyclophosphamide chemotherapy in female mice.

Prepubertal chemotherapy induced ovarian damage poses a significant threat to female fertility, particularly following cyclophosphamide (CP) treatment. Humanin (HNG), a small molecule polypeptide encoded by mitochondrial DNA, has a variety of effects, this study aimed to investigate the protective effects of HNG and its combination with conventional Gonadotropin Releasing Hormone Agonist (GnRHa) on ovarian function in a CP-induced damage model. The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.

Bioinspired thermally conducting packaging for heat management of high performance electronic chips.

Conventional electronic chip packaging generates a huge thermal resistance due to the low thermal conductivity of the packaging materials that separate chip dies and coolant. Here we propose and fabricate a closed high-conducting heat chip package based on passive phase change, using silicon carbide which is physically and structurally compatible with chip die materials. Our "chip on vapor chamber" (CoVC) concept realizes rapid diffusion of hot spots, and eliminates the high energy consumption of refrigeration ordinarily required for heat management.

Analysis of carbon reduction potential from typical municipal solid waste incineration plants under MSW classification.

The disposal of municipal solid waste (MSW) is a significant source of greenhouse gas (GHG) emissions. As incineration becomes the primary method of MSW disposal in China, MSW incineration (MSWI) plants are expected to play a crucial role in mitigating GHG emissions in the waste sector. This study estimated the quarterly GHG emissions from two representative MSWI plants in Qingdao using a life-cycle assessment (LCA) approach.

Evaluation of pollution potential in swine manure across growth stages: Impact of dietary nutrients and management strategies.

Regulation of dietary nutrient fractions to control the release of labile manure pollutants in swine production remains a challenge. Feeding trials were conducted to assess the impact of dietary nutrient fractions on labile manure composition and pollution potential in pigs at different growth stages. The pigs were selected based on age (weaning = 60 days, feeding = 100 days, and finishing = 160 days), health, and average body weight (23.

Altered Immune Cell Profiles in the Follicular Fluid of Patients with Poor Ovarian Response According to the POSEIDON Criteria.

Objective: This study aims to investigate alterations in immune cell counts within preovulatory follicles of patients with poor ovarian response (POR) during assisted reproductive technology (ART), classified according to the POSEIDON criteria.

Methods: This single-centre cross-sectional study included 543 women undergoing IVF/ICSI treatment, selected based on specific inclusion and exclusion criteria: 292 with normal ovarian response and 251 with poor response. Follicular fluid (FF) was collected on the day of oocyte retrieval and analysed by flow cytometry to determine the proportions of macrophages (Mφs), M1 and M2 Mφs, T cells (CD4 and CD8 T cells), dendritic cells (DCs), including type 1 conventional dendritic cells (cDC1) and type 2 conventional dendritic cells (cDC2), and neutrophils.

Decoding wheat contamination through self-assembled whole-cell biosensor combined with linear and non-linear machine learning algorithms.

The contamination of mycotoxins is a serious problem around the world. It has detrimental effects on human beings and leads to tremendous economic loss. It is essential to develop a rapid and non-destructive method for contamination recognition particularly for early alarm.

Exploring the heterogeneity of hepatic and pancreatic fat deposition in obesity: implications for metabolic health.

Objective: This retrospective observational study investigates the heterogeneity of hepatic and pancreatic fat deposition and its implications for metabolic health in individuals with obesity.

Methods: A total of 706 patients with obesity underwent an MRI to quantify liver and pancreatic fat. Patients were classified into four groups based on fat deposition: no fat (None), fatty pancreas only (NAFPD), fatty liver only (NAFLD), and both conditions (NAFLD+NAFPD).

Insights into bioaerosol contamination in the process of mineralized refuse mining: Microbial aerosolization behavior and potential pathogenicity.

The landfill mining process is a main source of anthropogenic bioaerosol release, posing potential risks to the health of occupationally exposed personnel and nearby residents. In this study, microbial aerosolization behavior and potential pathogenicity during the landfill mining process were systematically investigated. The highest concentration of bacterial aerosols was measured in the refuse mining area, with a value of 5968 ± 1608 CFU/m, while the highest concentration of fungal aerosols was 1196 ± 370 CFU/m in the refuse screening area.

Solidification/stabilization pre-treatment coupled with landfill disposal of heavy metals in MSWI fly ash in China: A systematic review.

The growth in municipal solid waste incineration (MSWI) has resulted in a substantial rise in the production of fly ash in China. It is anticipated that during the "14th Five-Year Plan", the accumulated amount of fly ash stocked and disposed of at landfills will surpass 100 million tons. With the development of the economy and the implementation of garbage classification relevant policies, the pollution characteristics of heavy metal change in spatiotemporal distribution.

Development of 3D-iNET ORION: a novel, pre-clinical, three-dimensional in vitro cell model for modeling human metastatic neuroendocrine tumor of the pancreas.

Neuroendocrine tumors (NETs) of the pancreas are rare neoplasms that present complex challenges to diagnosis and treatment due to their indolent course. The incidence of pancreatic neuroendocrine tumors has increased significantly over the past two decades. A limited number of pancreatic neuroendocrine cell lines are currently available for the research.

Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.

Male patients who undergo prepubertal chemotherapy face the dual problems of fertility preservation in adulthood, including low testosterone, hypersexual function, and infertility. Humanin, as a small polypeptide coded within the mitochondrial DNA, with the mitochondrial short open reading frame named MOTS-c, both was believed to regulate mitochondrial homeostasis, be anti-inflammatory, improve metabolism, anti-apoptosis, and multiple pharmacological effects. However, there exists little evidence that reported Humanin and MOTS-c 's effects on moderating male spermatogenic function of patients after prepubertal chemotherapy.

Epidemics and diversity of norovirus variants with acute gastroenteritis outbreak in Hongshan District, Wuhan City, China, 2021-2023.

Background: Norovirus is the predominant pathogen causing foodborne illnesses and acute gastroenteritis (AGE) outbreaks worldwide, imposing a significant disease burden. This study aimed to investigate the epidemiological characteristics and genotypic diversity of norovirus outbreaks in Hongshan District, Wuhan City.

Methods: A total of 463 AGE cases from 39 AGE-related outbreaks in Hongshan District between January 1, 2021, and June 30, 2023, were included in the study.

Lack of Nr2e1 expression in hepatocytes impaired cell survival and aggravated palmitate-induced oxidative stress.

Purpose: Nuclear receptor subfamily 2 group E member 1 (Nr2e1) has been regarded as an essential regulator in neural stem cells. However, its function is still not clear in hepatocytes. This study aimed to clarify the effects of Nr2e1-deficiency in hepatocytes in lipotoxic conditions.