Publications by authors named "HuaGuo Wu"

Article Synopsis
  • The FDA has approved various treatments for advanced metastatic renal cell carcinoma (mRCC), which includes both anti-vascular TKIs and immune checkpoint inhibitors (ICIs), but selecting the best treatment order for improved survival is still unclear.
  • This study aimed to assess the overall survival (OS) and progression-free survival (PFS) in mRCC patients based on treatment sequences involving TKIs and anti PD-1 therapies at a cancer hospital in Shandong, China.
  • Analysis involved 135 patients and highlighted that the treatment order affected survival outcomes, with some receiving anti PD-1 alone or combined with TKIs, allowing for comparisons of their effectiveness.
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Glioblastoma (GBM) is the most common primary brain tumor, and patients with GBM have a universally poor prognosis. Genomic profiling has detected epidermal growth factor receptor (EGFR) gene alterations in more than half of GBMs. Major genetic events include amplification and mutation of EGFR.

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Lung cancer patients with brain and leptomeningeal metastases usually have poor prognosis. For those patients with EGFR mutations, osimertinib, a third-generation tyrosine kinase inhibitor (TKI), is the first choice of treatment. However, drug resistance to osimertinib frequently occurs; and to date, the available follow-up treatment strategies have limited efficacy.

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Background: Diagnosis of Leptomeningeal Metastases (LM) from Non-Small Cell Lung Cancer (NSCLC) is usually based on clinical symptoms, Cerebral-Spinal Fluid (CSF) cytology, and neuro-imaging. However, early diagnosis of LM in NSCLC is challenging due to the low sensitivity of these approaches. The Next-Generation Sequencing (NGS) using CSF could help improve the diagnosis of LM and guide its treatment options.

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