Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities.

Clinical application of PD-1 and PD-L1 monoclonal antibodies (mAbs) is hindered by their relatively low response rates and the occurrence of drug resistance. Co-expression of B7-H3 with PD-L1 has been found in various solid tumors, and combination therapies that target both PD-1/PD-L1 and B7-H3 pathways may provide  additional therapeutic benefits. Up to today, however, no bispecific antibodies targeting both PD-1 and B7-H3 have reached the clinical development stage.

Development of a variant of dinutuximab with enhanced antitumor efficacy and reduced induction of neuropathic pain.

Dinutuximab (ch14.18) was the first approved monoclonal antibody against the tumor-associated antigen disialoganglioside GD2. Despite its success in treating neuroblastoma (NB), it triggers a significant amount of neuropathic pain in patients, possibly through complement-dependent cytotoxicity (CDC).

Co-production of acetoin and succinic acid by metabolically engineered Enterobacter cloacae.

Background: Renewable chemicals have attracted attention due to increasing interest in environmental concerns and resource utilization. Biobased production of industrial compounds from nonfood biomass has become increasingly important as a sustainable replacement for traditional petroleum-based production processes depending on fossil resources. Therefore, we engineered an Enterobacter cloacae budC and ldhA double-deletion strain (namely, EC∆budC∆ldhA) to redirect carbon fluxes and optimized the culture conditions to co-produce succinic acid and acetoin.

[Effects of cultivation patterns on the radiation use and grain yield of winter wheat].

Taking winter wheat cultivar 'Tainong 18' as test material, this paper set three treatments, local farmer's traditional cultivation pattern (FP), super high yield pattern (SH) and high yield high efficiency pattern ( HH) to investigate the effects of cultivation patterns on the intercepted photosynthetically active radiation (IPAR), PAR use efficiency (RUE), dry matter (DM) accumulation, harvest index (HI), grain yield and fertilizers' partial factor productivity (PFP) in 2012-2013. The results showed that IPAR, RUE and DM accumulation of the total growth stage and grain yield under SH pattern were significantly higher than those under FP pattern. IPAR of the total growth stage under HH pattern was lower than that under FP pattern, but RUE, DM accumulation and HI were significantly higher than that under FP pattern, so grain yield was higher than that under FP pattern.

Grafting of β-cyclodextrin to magnetic graphene oxide via ethylenediamine and application for Cr(VI) removal.

A novel β-cyclodextrin (β-CD) polymer adsorbent named β-cyclodextrin/ethylenediamine/magnetic graphene oxide (CD-E-MGO) was synthesized for decontamination of Cr(VI) from aqueous solution. The sorption kinetics, isotherms and thermodynamics, as well as the effects of pH, aniline and ionic strength on the sorption process were investigated. The results indicated that CD-E-MGO could effectively remove Cr(VI) from aqueous solution and the sorption data could be well described by pseudo-second-order and Langmuir models.

Etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in China.

Background: Appropriate antimicrobial therapy of community-acquired pneumonia (CAP) is mainly based on the distribution of etiology and antimicrobial resistance of major pathogens. We performed a prospective observational study of adult with CAP in 36 hospitals in China.

Methods: Etiological pathogens were isolated in each of the centers, and all of the isolated pathogens were sent to Zhongshan Hospital for antimicrobial susceptibility tests using agar dilution.

[Clinical significance of intermittent sinusoidal fetal heart rate at third trimester].

Objective: To investigate clinical significance of intermittent sinusoidal fetal heart rate at third trimester.

Methods: From Jan 2002 to Dec 2010, 48 pregnant women at 33 to 41 gestational weeks undergoing electronic fetal heart rate (FHR) monitoring presented with intermittent sinusoidal FHR in Department of Obstetrics and Gynecology, Second School of Clinical Medicine, Jinan University were enrolled in this retrospective study. Twenty-one cases were categorized into continuous group (i.