[Effects of zinc on activity of NOS and expression of nNOS in hippocampus of acute hypoxic mice].

Aim: To explore the effect of zinc on vigor of nitric oxide synthase (NOS) and the expression level of neuronal nitric oxide synthase (nNOS) in the hippocampus of acute hypoxic mice and the protective effects of zinc.

Methods: Model of acute hypoxic mice was duplicated, NADPH-d histochemistry and nNOS immunohistochemistry were used to investigate the changes of NOS in different groups.

Results: Compared with the NS group, the hypoxia endurance of the zinc group was significantly increased; the number of NOS positive neurons and nNOS positive neurons in hippocampus and CA1 were significantly decreased.

[Effects of taurine and zinc on activity of NOS and expression of nNOS in cerebral cortex of acute hypoxic mice].

Objective: To explore the effect of taurine and zinc on vigor of nitric oxide synthase (NOS) and the expression level of neuronal nitric oxide synthase (nNOS) in the cerebral cortex of acute hypoxic mice and the their neuroprotective effects.

Methods: Model of acute hypoxic mice was duplicated, NADPH-d histochemistry and nNOS immunohistochemistry were used to investigate the changes of NOS in different groups.

Results: Compared with the NS group, the anoxia endurance of the zinc sulfate group was increased 33.

[Inducible nitric oxide synthase gene expression in the testis of rats instilled with depleted uranium particles].

Objective: To explore genital toxicity of depleted uranium (DU) by studying the changes of inducible nitric oxide synthase (iNOS) in the testis of rats instilled with DU particles.

Methods: Wistar rats were exposed to DU by means of different dosages of DU particles intratracheal instillation. The samples of the testis were collected 3 months later, and iNOS mRNA was determined by reverse-transcription PCR (RT-PCR).