Association Between Anatomical Location and Hematoma Expansion in Deep Intracerebral Hemorrhage.

Objective: To establish the relationship between hematoma sites of involvement and hematoma expansion (HE) in patients with deep intracerebral hemorrhage (ICH).

Methods: Eligible patients with deep ICH admitted to hospital within 6 hours of onset between 2018 and 2020 were included in this retrospective multi-center study. Individuals with secondary ICH were excluded.

Newborn screening in Zhejiang, China.

Background: It has been 11 years since newborn screening started in Zhejiang in 1999. The aim of this study was to analyze and summarize the status of newborn screening in Zhejiang from 1999 to 2009.

Methods: Blood samples were collected from the heels of newborns 72 hours after birth.

Diagnosis and treatment of subclinical hypothyroidism detected by neonatal screening.

Background: This study was undertaken to explore the clinical outcome and prognosis of subclinical hypothyroidism detected by newborn screening.

Methods: Newborn screening was conducted at 1156 health care institutions in Zhejiang Province from October 1999 to September 2006. Included were (1) infants who had thyroid-stimulating hormone (TSH) ≥ 20 mU/L, and normal or lower normal levels of triiodothyronine (T(3)) and thyroxine (T(4)) and (2) infants with TSH between 5.

Thyrotropin receptor and thyroid transcription factor-1 genes variant in Chinese children with congenital hypothyroidism.

The aim of the present study was to investigate the mutation/variant of thyrotropin receptor (TSHR) and thyroid transcription factor-1 (TTF-1) genes in Chinese children with congenital hypothyroidism (CH). Seventy-nine and forty-nine Chinese children with CH were enrolled for molecular analysis of the TSHR gene and TTF-1 gene, respectively. One hundred normal children were evaluated as control.

[Application of CAD/CAM techniques in mandible large-scale defect and reconstruction with vascularized fibular bone graft].

Objective: To exploit computer-aided design and computer-aided manufactured (CAD/CAM) techniques and application in the reconstruction of mandible large-scale defect with vascularized fibular bone graft.

Methods: Before actually performing surgery, three-dimensional(3D) computed tomography(CT) was performed in 7 patients with mandibular large-scale defects, and 3D CT images were acquired by processing CT data. Then the CT data were transformed into a readable format and transferred to produce facsimile models by means of using rapid prototyping(RP) techniques.

[Observation time for drug administration and withdrawal in the treatment of children with congenital hypothyroidism].

Objective: To study the best observation time for drug administration and withdrawal in the treatment of children with transient congenital hypothyroidism,seeking an objective basis for the safe drug withdrawal.

Methods: Levothyroxine was prescribed for 1 144 children diagnosed with congenital hypothyroidism (CH) and according to the results levothyroxine was adjusted to a maintenance dosage. Examinations were performed periodically including physical and mental development, thyroid ultrasonography,and blood levels of T3, T4, TSH.

[Correlation of congenital hypothyroidism with birth weight and gestational age in newborn infants].

Objective: To investigate the correlation of congenital hypothyroidism (CH) with birth weight and gestational age in newborn infants.

Methods: The screening of CH was conducted in all the live births in 2005 of Zhejiang Province, the blood samples were collected from heel stick. The thyroid stimulating hormone (TSH) was measured by time-resolved fluorescence immunoassay (TRFIA).

[Effect of maternal autoimmune thyroid disease on intellectual development of infants].

Objective: To study the effect of maternal Hashimoto's disease (an autoimmune thyroid disease) on intellectual development of infants.

Methods: From July 2001 to June 2003, 21 infants born by mothers suffered from Hashimoto's disease were followed up with provincial neonatal disease screening network system. Their thyroid function was assessed and their mental development was evaluated with Gesell development schedules.

[Screening for congenital hypothyroidism in neonates of Zhejiang Province during 1999-2004].

Objective: To analyze the data of screening for congenital hypothyroidism (CH) newborns in Zhejiang Province during 1999-2004.

Methods: The dried blood samples were collected on filter paper. The levels of thyroid-stimulating hormone (TSH) were measured by time-resolved fluoroimmunoassay, and the serum levels of TSH, triiodothyronine (T(3)) and thyroxine (T(4)) were detected by chemiluminescence.

[Multifactorial analysis of effects of mothers' autoimmune thyroid disease on their infants' intellectual development].

Objective: To analyze factors relevant to retarded intellectual development in infants born to mothers with autoimmune disease of thyroid.

Methods: All the term newborns born to mothers with autoimmune thyroid disease (selection criteria) without asphyxia in all county, city, and provincial hospitals in Zhejiang province (except for Ningbo City) from July 2001 to June 2003 were enrolled through Zhejiang provincial neonatal disease screening network system. The control group was consisted of the neonates who were born to mothers without thyroid disease in these hospitals during the same period.