Prosthesis size distribution in Oxford phase III unicompartmental knee arthroplasty - Based on more than 1900 Chinese patients.

Introduction: It is difficult to determine the optimal size of unicompartmental knee arthroplasty (UKA) prosthesis both pre-operatively and intra-operatively. Inappropriate femoral and tibial components are still the leading cause of failure. Several guidelines based on the Western population may not apply to the Chinese patients.

Clinical Outcomes and Risks of Single-stage Bilateral Unicompartmental Knee Arthroplasty via Oxford Phase III.

Background: Osteoarthritis often affects the joint bilaterally, and the single-stage (SS) unicompartmental knee arthroplasty (UKA) is advantageous in terms of a single anesthesia administration, a short hospital stay, lower medical costs, and enhanced patient convenience. However, the complication risk of SS UKA continues to be debated. The aim of this article was to evaluate the clinical effectiveness, complications, and functional recovery of SS and two-stage (TS) UKA.

[Pre-operative assessment of the patellofemoral joint in unicompartmental knee replacement using Oxford Phase III and its influence on outcome].

Objective: To determine whether anterior knee pain and/or radiological evidences of degeneration of the patellofemoral joint influence the outcome of unicompartmental knee arthroplasty (UKA).

Methods: Between January 2006 and December 2010, 95 consecutive patients (100 knees) with unicompartmental knee osteoarthritis were treated with Oxford UKA, including 34 males and 61 females. The mean age was 68.

[Morphological changes in osteosarcoma xenografts in nude mice after inhibiting angiogenesis by Ad-VEGF-siRNA].

Background And Objective: Vascular endothelial growth factor (VEGF) is a critical stimulator for angiogenesis of osteosarcoma. This study was to investigate the morphological changes in osteosarcoma xenografts in nude mice after inhibiting angiogenesis by Ad-VEGF-siRNA.

Methods: The animal model of osteosarcoma xenografts was constructed by subcutaneous inoculation of osteosarcoma MG63 cells into nude mice.

Inhibitory effects of VEGF-siRNA mediated by adenovirus on osteosarcoma-bearing nude mice.

As one of the blood-rich malignancies, the growth and metastasis of osteosarcoma both depend on its angiogenesis, a procedure in which vascular endothelial growth factor (VEGF) acts essentially. Although with the advent of neoadjuvant chemotherapy, more aggressive surgical excision and logical therapy strategy, the 5-year survival rate remains relatively stable at 70%, at best. However, antiangiogenic therapeutics, through gene silencing and targeting key sequences, probably brings an outlook to the conventional algorithm.