Publications by authors named "Hua-bing Tan"
Circular RNAs (circRNAs) have been demonstrated to play important roles in cancer progress. However, the roles in hepatocellular carcinoma (HCC) are still unclear. Here, we found has_circRNA_001306 (circ_1306) was up-regulated in HCC tissues and cell lines.
View Article and Find Full Text PDFThe immune cells within the tumor microenvironment (TME) play important roles in tumorigenesis. It has been known that these tumor associated immune cells may possess tumor-antagonizing or tumor-promoting functions. Although the tumor-antagonizing immune cells within TME tend to target and kill the cancer cells in the early stage of tumorigenesis, the cancer cells seems to eventually escape from immune surveillance and even inhibit the cytotoxic function of tumor-antagonizing immune cells through a variety of mechanisms.
View Article and Find Full Text PDFIn order to evaluate the potential application value of cidofovir (CDV) in the prevention of human papillomavirus (HPV) infection and treatment of cervical cancer, the inhibitory effect of CDV on the proliferation of HPV 18-positive HeLa cells in cervical cancer was preliminarily investigated, using cisplatin (DDP) as a positive control. An MTT assay was used to analyze the effects of CDV and DDP on HeLa cell proliferation. In addition, clone formation assay and Giemsa staining were used to examine the extent of HeLa cell apoptosis caused by CDV and DDP.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigated the link between Helicobacter pylori (HP) infection and periodontal disease (PD) using a case-control approach with patients diagnosed with PD and a control group without PD.
- - The research involved 212 non-smoking Han Chinese adults and found that being HP-positive significantly increased the risk of developing PD, with an odds ratio of 2.63 before adjustments and 2.82 after accounting for various factors.
- - The findings suggest that HP infection could be a significant and independent risk factor for periodontal disease in adults.
Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats.
World J Gastroenterol
February 2015
Aim: To explore the mechanism of action of gypenosides (GPs) on type 2 diabetes mellitus and non-alcoholic fatty liver disease (T2DM-NAFLD) in rats.
Methods: Sixty rats were randomly divided into a healthy group, an untreated disease model group and GP-treatment groups. The study involved the evaluation of biochemical parameters, including serum aspartate transaminase (AST), alanine transferase (ALT), blood glucose (BG), triglycerides (TG) and total cholesterol (TC).