Publications by authors named "Hua-Zhang Guo"
Article Synopsis
- Lipogenesis in porcine adipocytes is regulated by transcription factors ChREBP and SREBP-1c in response to glucose and insulin, with ChREBP primarily mediating glucose-induced lipogenesis.
- When ChREBP is silenced, glucose-induced lipogenesis drops by about 70%, while insulin-induced lipogenesis remains unchanged, revealing distinct pathways for these two stimuli.
- LXRα also plays a role in promoting lipogenesis, potentially via SREBP-1c, as it enhances lipogenesis when both ChREBP and SREBP-1c activities are inhibited, indicating that LXRα can directly mediate glucose- and insulin-induced lipogenesis.
Aim: To obtain human recombinant Fv-immunotoxin hscFv(25)-mTNFalpha (mutant human TNFalpha fused to human scFv(25)) against hepatocellular carcinoma (HCC).
Methods: Two relevant sites of enzymatic digestion were added to mTNFalpha by PCR. MTNFalpha was linked to the 3' end of hscFv(25) in pGEX4T-1 vector.
[A HLA-A2-restricted-CTL epitope variation at the N-terminal of HCV helicase and the immune response of CTLs].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
May 2004
Aim: To investigate a HLA-A2-restricted CTL epitope variation at the N terminal of hepatitis C virus (HCV) helicase and the proliferative response of cytotoxic T lymphocytes (CTLs) to this epitope.
Methods: Two patients infected with HCV were followed up for 7 years. Blood samples taken at the first year and the fifth year were used for viral RNA extraction.
Aim: Quasispecies of hepatitis C virus (HCV) are the foundation for rapid sequence evolution of HCV to evade immune surveillance of hosts. The consensus sequence evolution of a segment of HCV NS3 region, which encompasses putative cytotoxic T cell epitopes, was evaluated.
Methods: Three male patients, infected with HCV through multiple transfusions, were identified from clinical symptoms and monitored by aminotransferase for 60 months.