Publications by authors named "Hua-Ying Xia"
J Cell Biochem
April 2019
Article Synopsis
- 20(S)-protopanaxadiol (PPD) from Panax ginseng shows anti-cancer properties by inducing apoptosis in cancer cells and has a complex role in endothelial cell growth depending on its concentration.
- High concentrations of 20(S)-PPD inhibit the growth of human umbilical vein endothelial cells (HUVECs) by inducing apoptosis through activation of caspases and endoplasmic reticulum (ER) stress signaling mechanisms.
- The study reveals that the PERK-eIF2α pathway and the subsequent activation of ATF4 are crucial for the apoptosis induced by 20(S)-PPD, indicating its potential for treating diseases related to abnormal blood vessel growth.
