Publications by authors named "Hua-Yi Li"
Article Synopsis
- Tumor-associated macrophages (TAMs) are crucial in modulating immune responses and help tumors evade the immune system, but their interactions with tumor cells are not fully understood.
- The study found that interleukin-1β (IL-1β) is a key cytokine that enhances immune suppression by inhibiting CD8 T cell activity in ovarian cancer, primarily through increased expression of PD-L1 in tumor cells.
- Targeting IL-1β with neutralizing antibodies showed promise in reducing tumor growth and improving the effectiveness of anti-PD-L1 treatment in mouse models, indicating its potential as a therapeutic target to enhance cancer immunotherapy.
Article Synopsis
- Platelets can be influenced by cancer through a process called education, leading to a specific transcriptional profile that can aid in cancer detection, particularly for ovarian cancer.
- A study involving 761 patients with confirmed adnexal masses and 167 healthy controls across multiple countries showed that tumor-educated platelets (TEPs) had a high diagnostic accuracy, with AUCs (area under the curve) ranging from 0.887 to 0.923 in validation cohorts.
- Combining TEPs with the CA125 biomarker further improved detection accuracy, and TEPs showed potential across diverse populations and cancer stages, but further extensive studies are necessary before they can be widely used in clinical settings.
Finely tuned mitogen-activated protein kinase (MAPK) signaling is important for cancer cell survival. Perturbations that push cells out of the MAPK fitness zone result in cell death. Previously, in a screen of the North China Pharmaceutical Group Corporation's pure compound library of microbial origin, we identified elaiophylin as an autophagy inhibitor.
View Article and Find Full Text PDFSoaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. Here, we present a mortality risk prediction model for COVID-19 (MRPMC) that uses patients' clinical data on admission to stratify patients by mortality risk, which enables prediction of physiological deterioration and death up to 20 days in advance.
View Article and Find Full Text PDF8-Chloro-adenosine (8-Cl-Ado) has been shown to exhibit its antitumor activity by inducing apoptosis in human lung cancer A549 and H1299 cells or autophagy in chronic lymphocytic leukemia, and MDA-MB-231 and MCF-7 breast cancer cells. Adenosine deaminases acting on RNA 1 (ADAR1) is tightly associated with cancer development and progression. The aim of this study was to investigate the role of ADAR1 in the proliferation of MDA-MB-231 and SK-BR-3 breast cancer cell lines after 8-Cl-Ado exposure and its possible mechanisms.
View Article and Find Full Text PDFDue to the early administration of antibiotics, meningococcal disease is increasingly difficult to diagnose by culturing. Laboratory studies have shown PCR to be sensitive and specific, but there have been few clinical studies. The objectives of this study were to determine the diagnostic accuracy and clinical usefulness of meningococcal PCR through a prospective comparison of real-time PCR, nested PCR, and standard culturing of blood and cerebrospinal fluid (CSF).
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