Publications by authors named "Hua-Yi Feng"
Objectives: To evaluate the prognostic value of systemic Inflammation Response Index (SIRI) in patients with renal cell carcinoma and inferior vena cava tumor thrombus (RCC-IVCTT) treated with radical nephrectomy and IVCTT thrombectomy.
Methods: We retrospectively reviewed the clinical data of 144 consecutive patients with RCC-IVCTT who received radical nephrectomy and IVCTT thrombectomy at our center from January 2008 to August 2018. Receiver operating characteristic curve analysis was performed to calculate the optimal cutoff value of preoperative SIRI.
Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and typically has a poor prognosis, prompting research into immune response enhancement strategies.
- Fibrinogen-like Protein 1 (FGL1) plays a role in helping tumors escape the immune system by interacting with LAG-3 and repressing T cell activity; its high levels in ccRCC are linked to worse patient outcomes.
- The study demonstrates that elevated FGL1 not only promotes tumor cell migration and metastasis through epithelial-to-mesenchymal transition (EMT), but also alters immune cell infiltration in the tumor microenvironment, suggesting that targeting FGL1 could improve treatment results for ccRCC patients.
Backgrounds: CD146 is highly expressed in various malignant tumors and associated with the poor prognosis. However, the role of CD146 in clear cell renal cell carcinoma (ccRCC) is still unknown. This study aimed to identify the role of CD146 in ccRCC by integrated bioinformatics analysis.
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