Publications by authors named "Hua-Wen Xu"
Article Synopsis
- The oral microbiome, composed of various microorganisms, is important in cancer development and progression and is recognized as one of the "Hallmarks of Cancer".
- Factors like maternal transmission and environmental conditions influence the composition and function of the oral microbiota, and disruptions (dysbiosis) can lead to systemic diseases.
- The review highlights the interaction between oral microbiota and their environment, the health effects of this multi-kingdom community, and explores potential mechanisms and therapeutic strategies for targeting oral microbiota in cancer prevention and treatment.
Amyloid-β (Aβ) has been reported to cause oxidative damage of neurons leading to neurotoxicity in a variety of diseases and cancers. As an anticancer drug, brusatol (BR) has been shown to have potent cytotoxic effects on various cancer cell lines. In this study, the effect and mechanism of BR on Aβ-induced neurotoxicity was investigated in U-251 glioma cells.
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