Thoughts and suggestions about ethical requirement in acupuncture animal experiments.

The animal experiment is an important form of acupuncture research, which is of great significance for revealing the regularities and mechanisms of acupuncture effects. The ethical principle of animal welfare is the important guarantee of animal rights and experimental scientificity in the process of research. Starting from the "3R principle" and "five welfare" rules, and the specific operation process of acupuncture animal experiments, we, in this paper, proposed the implementation methods of animal ethics in acupuncture experiments, including ethical execution before acupuncture experiments, and ethical requirements during the experimental stage (such as animal fixation method that meets the needling needs, selection of acupuncture apparatus, acupuncture manipulations, acupuncture stimulation intensity, and sampling of animal tissues).

Juglanin alleviates bleomycin-induced lung injury by suppressing inflammation and fibrosis via targeting sting signaling.

Idiopathic pulmonary fibrosis (IPF), characterized by excessive collagen deposition, is a progressive and typically fatal lung disease without effective therapeutic strategies. Juglanin, as a natural product mainly isolated from green walnut husks of Juglans mandshuric, has various bioactivities, including anti-oxidative, anti-inflammatory and anti-fibrotic effects. Stimulator of interferon genes (Sting) is a signaling molecule and plays an essential role in meditating fibrosis.

Randomized clinical trial: the clinical effects of herb-partitioned moxibustion in patients with diarrhoea-predominant irritable bowel syndrome.

Objective. To explore the efficacy of Herb-partitioned moxibustion in treating IBS-D patients. Method.

A clinical trial of acupuncture about time-varying treatment and points selection in primary dysmenorrhea.

Objective: To observe the clinical therapeutic effects of acupuncture at single point Shiqizhui (EX-B8) and multi-points in time-varying treatment for primary dysmenorrhea.

Methods: 600 patients with primary dysmenorrhea were randomly assigned to the single point group (n=200) including group A (treating before the menstruation, n=100) and group B (immediately treating as soon as pain occurrence, n=100), the multi-points group (n=200) including group C (treating before the menstruation, n=100) and group D (immediately treating as soon as pain occurrence, n=100), or the control group, group E (n=200, no treatment). The therapeutic effects were analyzed after treatment for three menstrual cycles and interviewed for three follow-up periods.