Publications by authors named "Hua-Min Ding"
Objective: Cisplatin (CDDP)-based chemotherapy is a first-line, drug regimen for muscle-invasive bladder cancer (BC) and metastatic bladder cancer. Clinically, resistance to CDDP restricts the clinical benefit of some bladder cancer patients. AT-rich interaction domain 1A (ARID1A) gene mutation occurs frequently in bladder cancer; however, the role of CDDP sensitivity in BC has not been studied.
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- * The study investigated how Jagged1-Notch signaling is affected by Ang II in the context of this impaired angiogenesis and cardiac hypertrophy using male mice and specific treatments.
- * Results indicated that Ang II caused significant cardiac hypertrophy and reduced angiogenesis, while the protein Jagged1 increased but its gene expression decreased in the heart tissue, suggesting a complex interaction in the disease process.
Sortilin-related VPS domain containing receptor 1 (SORCS1), is located on chromosome 10q23.3, a chromosomal region of interest in Alzheimer's disease (AD) defined by many genome-wide and chromosome10-specific studies. Recently, three intronic variants (rs12571141, rs17277986 and rs6584777) within SORCS1 were reported to be associated with AD in Caucasian.
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