Adverse reactions and their management in the treatment of malignant tumors using cytokine-induced killer cells.

Objective: To identify the causes and the corresponding management of adverse reactions during the treatment of malignant tumors using cytokine-induced killer cells.

Methods: From January 2012 to December 2012, 441 patients received a total of 1,393 autologous cytokine-induced killer cell transfusion cycles in our department. The adverse reactions after the procedures were observed (assessed using the National Cancer Institute Common Toxicity version 2.

Sequential chemoradiotherapy with gemcitabine and cisplatin for locoregionally advanced nasopharyngeal carcinoma.

We investigated a new chemoradiotherapy (CRT) regimen for locoregionally advanced nasopharyngeal carcinoma (NPC). A total of 240 patients were randomly assigned to three different CRT regimens: sequential CRT [1 cycle chemotherapy + Phase I radiotherapy (RT) + 1 cycle chemotherapy + Phase II RT + 2 cycles chemotherapy] with a cisplatin-gemcitabine (GC) regimen (800 mg/m(2) gemcitabine on Days 1 and 8 and 20 mg/m(2) cisplatin on Days 1-5, every 4 weeks) (sGC-RT); sequential chemoradiotherapy with a cisplatin-fluorouracil (PF) regimen (20 mg/m(2) DDP and 500 mg/m(2) 5-FU on Days 1-5, every 4 weeks) (sPF-RT) and cisplatin-based concurrent chemoradiotherapy plus adjuvant PF chemotherapy (Con-RT + PF). The complete response rate was higher in the sGC + RT group than in the other two groups (98.

Item selection in the development of quality of life scale for nasopharyngeal carcinoma patients.

Background And Objective: At present, the quality of life (QOL) of nasopharyngeal carcinoma (NPC) patients is assessed with the QOL scales for cancer patients or head and neck cancer patients (QLQ-C30, QLQ-H&N35, and so on), and SF-36 scale, but they are not specific scales for NPC patients. The specific scale for NPC patients (Scale of Quality of Life for Nasopharyngeal Carcinoma, SQOL-NPC) has not been updated. This study was to develop a QOL scale (Quality of Life for Nasopharyngeal Carcinoma, QOL-NPC) for NPC patients in China.

[Influence of vacuum bag on direct measurement of depth for isocentric posterior oblique field].

Background & Objective: In order to improve quality assurance (QA) and quality control (QC) of radiotherapy, individualized vacuum bag is used in the localization of radiation treatment, gradually becoming one of the important steps for the QA and QC in the many departments of radiation oncology. It is controversial whether localization with vacuum bags under the simulator influences the precision of direct measurement for tumor depth in the isocentric posterior oblique field in the patients with thoracic and abdominal tumors. This study was designed to explore the influence of vacuum bag on the direct measurement

Methods: Twenty-nine patients with thoracic and abdominal carcinoma who had to need isocentric irradiation in the supine position were immobilized using vacuum bag.