Molecular Mediators of Estrogen Reduction-induced Otolith Shedding.

Objective: Previous study suggested that estradiol (E2) plays an important role in otolith shedding by regulating the expression of otoconin 90 (OC90). The purpose of this article is to provide further data on the effect and mechanism of E2 on the morphology of otolith.

Methods: The rats receiving bilateral ovariectomy (OVX) were used as animal models.