Publications by authors named "Hua-Feng Yin"
Article Synopsis
- The study focused on creating an optimized self-nanoemulsifying drug delivery system (SNEDDS) for Genkwanin (GKA) to improve its solubility, intestinal absorption, and effectiveness against colitis-associated colorectal cancer (CAC).
- The formulation was developed by testing various oils and surfactants, leading to a successful mixture that enhanced GKA's properties, making it more bioavailable and effective in a mouse model of CAC.
- The optimized GKA-SNEDDS resulted in a remarkable 353.28% increase in bioavailability compared to regular GKA and demonstrated significant improvements in health metrics and inflammation reduction in the experimental model of cancer.
[Pharmacokinetics of mestinon-phospholipid complex in rats].
Sichuan Da Xue Xue Bao Yi Xue Ban
November 2012
Objective: To determine the pharmacokinetics characteristics of mestinon-phospholipid complex (PBPLC) in rats.
Methods: This study adopted a single-dose, randomized, open-label, two-period crossover trial design. Twelve healthy rats were randomly divided into two groups.
Objective: Previous studies on various enzymosomes (functional lipid vesicles encapsulating an enzyme) have been mostly carried out in vitro and have focused on preserving catalytic activity and improving the stability of the enzyme. Until now, few studies have focused on their in vivo fate. Similarly, although we have previously reported the increased in vitro uricolytic activity (about 2.
View Article and Find Full Text PDFA novel pyridostigmine bromide (PB)-phospholipid nanocomplex (PBPLC) was prepared to increase the bioavailability of PB. A central composite design approach was employed for process optimization. The physicochemical properties of PBPLC were investigated by means of differential scanning calorimetry, ultraviolet spectroscopy, Fourier transformed infrared spectroscopy and the n-octano/water partition coefficient.
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