Mitochondrial phosphate carrier plays an important role in virulence of .

is a common fungal pathogen that can cause life-threatening infections. is considered to be a mitochondrial phosphate carrier of , while its role in virulence has not been fully elucidated. In this study, we found that mutant exhibited severe virulence defect in both nematode and murine models.

Limited Applicability of Neoclassical Facial Canons in Tibetan Youth: 2D Photogrammetry Evaluation.

Neoclassical facial proportion canons have long served as benchmarks for defining facial beauty across diverse populations. However, their applicability varies significantly among ethnic groups. This study critically evaluates the validity of these canons among young Tibetan adults in China, with a particular focus on vertical and horizontal facial proportions.

ZNF667 alleviates the inflammatory damage in intervertebral disc degeneration via inhibiting NF-κB signaling pathway.

Objectives: With the aging population, the incidence of intervertebral disc degeneration (IDD) is increasing every year. The pathogenesis of IDD is complex, and there are currently no effective treatment options. This study aims to investigate the specific function and underlying mechanism of zinc finger protein 667 (ZNF667) in the inflammatory damage of nucleus pulposus cells in IDD.

Determinants of late metastases in renal cell carcinoma.

The mechanisms underlying metastatic latency in renal cell carcinoma (RCC) remain poorly understood. This study evaluated two large independent cohorts for differences in tumor biology between patients who developed metastases early (≤1 year after nephrectomy) and those with late-onset (>3 years). In the discovery cohort (n = 161), late-metastatic RCC (late-mRCC) was associated with clear cell histology (88.

Three-dimensional and magnified CT images of displaying the imaging features of invasive adenocarcinoma of lung.

Objective: To discuss CT imaging characteristics of invasive adenocarcinoma of lung(IACL).

Methods: CT revealed the nodule of lung which pathology confirmed as IACL of 290 cases. Imaging data were retrospectively analyzed by dividing into high-risk group of 115 cases and low-risk group of 175.

Factors Influencing eHealth Literacy Worldwide: Systematic Review and Meta-Analysis.

Background: eHealth literacy has increasingly emerged as a critical determinant of health, highlighting the importance of identifying its influencing factors; however, these factors remain unclear. Numerous studies have explored this concept across various populations, presenting an opportunity for a systematic review and synthesis of the existing evidence to better understand eHealth literacy and its key determinants.

Objective: This study aimed to provide a systematic review of factors influencing eHealth literacy and to examine their impact across different populations.

Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China.

Background: Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outcomes for patients with advanced non-small cell lung cancer in early-phase studies. We compared the efficacy and safety of ivonescimab with pembrolizumab in patients with programmed cell death ligand-1 (PD-L1)-positive advanced non-small cell lung cancer.

Methods: HARMONi-2 is a randomised, double-blind, phase 3 trial across 55 hospitals in China.

Ultrasound-activated piezoelectric heterojunction drives nanozyme catalysis to induce bacterial cuproptosis-like death and promote bone vascularization and osseointegration.

Osteomyelitis is a severe and persistent bone infection that poses significant challenges to clinical treatment, often requiring prolonged antibiotic therapy and invasive procedures. Nanomaterial-based non-antibiotic therapies have emerged as promising alternatives in combating bacterial infections. However, effectively treating osteomyelitis while simultaneously promoting bone repair remains a challenge.

Insight into Peroxymonosulfate Activation Catalyzed by Fe/Mn Bimetallic-Loaded In Situ Nitrogen-Doped Biochar: the Critical Role of Singlet Oxygen and Superoxide Radicals.

Water pollution caused by emerging contaminants poses significant environmental and health risks, while the management of invasive algal biomass remains an underutilized resource. This study presents a novel Fe/Mn-modified in situ N-doped -derived biochar catalyst (Fe/Mn/EP), addressing the dual challenges of efficient peroxymonosulfate (PMS) activation and utilization of invasive algal biomass. Through a straightforward one-step pyrolysis approach, the obtained catalyst integrated nitrogen functionalities and bimetallic active sites, enabling it to achieve an outstanding catalytic performance.

Analysis of clinical and imaging characteristics of pseudocirrhosis in breast cancer liver metastasis.

Background: Pseudocirrhosis that may be triggered by the treatment of breast cancer liver metastasis often begins insidiously and progresses rapidly. This complicates the accurate assessment of tumor growth or regression. Without timely intervention, patients are at significant risk of death due to acute liver failure or bleeding from ruptured varices.

BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC), a metabolic disease originating from renal proximal convoluted tubule (PCT) epithelial cells, remains incompletely understood in terms of its initiating signaling events. Here, we identify γ-butyrobetaine hydroxylase 1 (BBOX1), a key enzyme in carnitine synthesis predominantly expressed in PCT cells, as a tumor suppressor in ccRCC. BBOX1 expression is lost during ccRCC malignant transformation, and its restoration reduces cell viability in physiological medium and inhibits xenograft tumor growth.

Similarities in the kinematics of autografts and hybrid grafts for anterior cruciate ligament reconstruction: Minimum 2 years of follow-up.

Objective: To compare the clinical results of anterior cruciate ligament reconstruction (ACLR) with autografts and that with hybrid grafts of the same diameter.

Methods: This study retrospectively included 102 patients who underwent ACLR from August 2017 to July 2019. According to graft type, the patients were divided into an autograft group (58 patients) and a hybrid graft group (44 patients).

Motion feature extraction using magnocellular-inspired spiking neural networks for drone detection.

Traditional object detection methods usually underperform when locating tiny or small drones against complex backgrounds, since the appearance features of the targets and the backgrounds are highly similar. To address this, inspired by the magnocellular motion processing mechanisms, we proposed to utilize the spatial-temporal characteristics of the flying drones based on spiking neural networks, thereby developing the Magno-Spiking Neural Network (MG-SNN) for drone detection. The MG-SNN can learn to identify potential regions of moving targets through motion saliency estimation and subsequently integrates the information into the popular object detection algorithms to design the retinal-inspired spiking neural network module for drone motion extraction and object detection architecture, which integrates motion and spatial features before object detection to enhance detection accuracy.

Efficacy of first-line chemotherapy combined with immunotherapy or anti-angiogenic therapy in advanced KRAS-mutant non-small cell lung cancer.

Background: Approximately 30 % non-small cell lung cancer (NSCLC) patients carry KRAS mutations in western countries. First-line chemotherapy combined with immunotherapy has been the standard therapeutic regimen for KRAS-mutant NSCLC patients. This population could also benefit from chemotherapy combined with anti-angiogenic therapy.

Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction: Results of a Multicenter Randomized Controlled Trial.

Background: Elevated perceived stress is associated with adverse outcomes following myocardial infarction (MI) and may account for poorer recovery among women vs men.

Objectives: This randomized controlled trial tested effects of a mindfulness-based intervention on stress levels among women with MI.

Methods: Women with elevated stress (Perceived Stress Scale [PSS-4]≥6) at least 2 months after MI were enrolled from 12 hospitals in the United States and Canada and via community advertising.

Integration of the partition effect into the model of non-aqueous phase liquid solubilization by non-ionic surfactant.

Accurately predicting the efficiency of surfactant-enhanced recovery of non-aqueous phase liquid (NAPL) using non-ionic surfactants requires a precise estimation of the kinetics of rate-limited solubilization under the effect of bulk partition. This study investigated the kinetics of surfactant partition from aqueous phase into liquid NAPL and its subsequent impact on the solubilization kinetics of dodecane. For all surfactants examined, the solubilization of dodecane by anionic rhamnolipid (RL) and SDBS, presenting NAPL-water interface adsorption loss only, closely followed the first-order mass transfer model under the assumption of constant solubility.

Transcriptome-Wide Association Study Identified Novel Blood Tissue Gene Biomarkers for Prostate Cancer Risk.

Objective: A number of susceptibility genes in prostate tissue have been identified to be associated with prostate cancer (PCa) risk. However, the reported genes based on assessing prostate tissue could not fully explain PCa genetic susceptibility. It is believed that genes functioning in the immune system may fill in the gap of some missing heritability.

Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation.

Background: Chronic kidney disease (CKD) is a progressive condition that arises from diverse etiological factors, resulting in structural alterations and functional impairment of the kidneys. We aimed to establish the Anoikis-related gene signature in CKD by bioinformatics analysis.

Methods: We retrieved 3 datasets from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs), followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) of them, which were intersected with Anoikis-related genes (ARGs) to derive Anoikis-related differentially expressed genes (ARDEGs).

Prognostic Value of Dynamic Measurable Residual Disease Monitoring by Multiflowcytometry in Elderly Patients With Nonintensively Treated Acute Myeloid Leukemia.

Purpose: The clinical prognostic value of monitoring minimal residual disease (MRD) in acute myeloid leukemia (AML) patients undergoing nonintensive treatment remains insufficiently established. The aim of this work was to examine MRD status at various time points, highlighting the potential for pre-emptive therapy to improve patient outcomes.

Methods: Inpatient data from 2017 to 2024 were used in this retrospective study.

Clinical features of inflammatory arthritis in daily practice-China's perspective.

Objective: This study aimed to analyze and compare the proportion of patients with different types of inflammatory arthritis and investigate the clinical characteristics, including symptoms and signs, medication choices, and disease activity, in the daily clinical practice of China.

Methods: Patients with inflammatory arthritis were recruited from 16 Grade-A tertiary hospitals between August 2021 and April 2022. The medical profiles, encompassing sociodemographic characteristics, clinical and laboratory date, were collected.

Gender Disparities in Pandemic-Related Strains, Digital Coping Strategies, and Protective Mechanisms Among Rural-to-Urban Migrant Working Adolescents in China.

The COVID-19 pandemic placed significant strains on daily life, particularly affecting vulnerable groups such as rural-to-urban young migrant workers. Based on General Strain Theory (GST), these pandemic-related strains lead to delinquent copings, including excessive Internet use. However, the association between pandemic-related challenges faced by migrant youth and their digital copings has yet to be investigated.

Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor.

Background: Targeting exportin1 (XPO1) with Selinexor (SEL) is a promising therapeutic strategy for patients with multiple myeloma (MM). However, intrinsic and acquired drug resistance constitute great challenges. SEL has been reported to promote the degradation of XPO1 protein in tumor cells.

Efficacy and safety of first-line sintilimab plus anlotinib versus chemotherapy for metastatic non-small cell lung cancer: a phase II, open-label, randomized controlled trial.

Background: The prognosis for non-small cell lung cancer (NSCLC) patients treated with standard platinum-based chemotherapy was suboptimal, with safety concerns. Following encouraging results from a preliminary phase I study, this phase II trial investigated the efficacy and safety of first-line sintilimab and anlotinib in metastatic NSCLC.

Methods: In this open-label, randomized controlled trial (NCT04124731), metastatic NSCLC without epithelial growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), or proto-oncogene tyrosine-protein kinase ROS (ROS1) mutations, and previous treatments for metastatic disease were enrolled.

Soil aggregation alterations under soil microplastic and biochar addition and aging process.

Soil microplastics (MPs) are a substantial threat to soil health, particularly by disrupting soil aggregation. Additionally, MPs undergo aging processes in the soil, which may significantly alter their long-term impacts on soil structure. To investigate these effects, we conducted an eight-month soil incubation experiment, examining the influence of MPs and their aging on soil aggregation.

The Associations Between Myopia and Fundus Tessellation in School Children: A Comparative Analysis of Macular and Peripapillary Regions Using Deep Learning.

Purpose: To evaluate the refractive differences among school-aged children with macular or peripapillary fundus tessellation (FT) distribution patterns, using fundus tessellation density (FTD) quantified by deep learning (DL) technology.

Methods: The cross-sectional study included 1942 school children aged six to 15 years, undergoing ocular biometric parameters, cycloplegic refraction, and fundus photography. FTD was quantified for both the macular (6 mm) and peripapillary (4 mm) regions, using DL-based image processing applied to 45° color fundus photographs.