Hidden blood loss in percutaneous endoscopic lumbar discectomy via the posterolateral approach.

Objectives: The study aimed to evaluate the hidden blood loss (HBL) and its possible risk factors in patients with lumbar disc herniation undergoing percutaneous endoscopic lumbar discectomy (PELD) via posterolateral approach.

Patients And Methods: The clinical data of 170 lumbar disc herniation patients (101 males, 69 females; mean age: 57.7±18.

Effective xylan integration for remodeling biochar uniformity and porosity to enhance chemical elimination and CO adsorption.

Although plant evolution has offered diverse biomass resources, the production of high-quality biochar from desirable lignocelluloses remains unexplored. In this study, distinct lignocellulose substrates derived from eight representative plant species were employed to prepare biochar samples under three different temperature treatments. Correlation analysis showed that only hemicellulose was a consistently positive factor of lignocellulose substrates to account for the dye-adsorption capacities of diverse biochar samples.

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial.

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection.

Objectives: Determine valoctocogene roxaparvovec durability, efficacy, and safety 4 years after treatment.

Methods: In the phase 3 GENEr8-1 trial, 134 adult male persons with severe hemophilia A without inhibitors and previously using FVIII prophylaxis received a 6 × 10 vg/kg infusion of valoctocogene roxaparvovec.

Melatonin enhances metal oxide nanoparticles tolerance in rice seedlings through dual regulation of antioxidant defense and photosynthetic efficiency.

The growing utilization of metal oxide nanoparticles (MONPs) presents novel and potential hazards to plants. However, the impacts of MONPs on plants and the mechanisms underlying their tolerance to MONPs remain unclear. In this study, we demonstrated that both CuO and ZnO nanoparticles hindered plant growth and triggered oxidative damage in rice seedlings.

Efficacy of bright light therapy improves outcomes of perinatal depression: A systematic review and meta-analysis of randomized controlled trials.

The efficacy of bright light therapy (BLT) in the context of perinatal depression remains underexplored. This meta-analysis aimed to systematically assess the effectiveness of BLT among perinatal depression. A comprehensive literature search was performed across several databases, including the Cochrane Central Register of Controlled Trials, PubMed, Embase, CNKI and the clinical trials registry platform, covering the period from the inception of each database up to January 2024.

Tanshinone I improves renal fibrosis by promoting gluconeogenesis through upregulation of peroxisome proliferator-activated receptor-γ coactivator 1α.

Background: Renal fibrosis, a hallmark of chronic kidney disease, is closely associated with dysregulated gluconeogenesis. Tanshinone I (Tan I), a bioactive compound derived from the traditional Chinese medicine Danshen, exhibits antifibrotic and anti-inflammatory properties. However, its effects on gluconeogenesis and the mechanisms through which it alleviates renal fibrosis remain unclear.

Local CpG- siRNA treatment improves antitumor effects of immune checkpoint inhibitors.

Immune checkpoint blockade (ICB) therapy has significantly benefited patients with several types of solid tumors and some lymphomas. However, many of the treated patients do not have a durable clinical response. It has been demonstrated that rescuing exhausted CD8 T cells is required for ICB-mediated antitumor effects.

A ROS-responsive hydrogel that targets inflamed mucosa to relieve ulcerative colitis by reversing intestinal mucosal barrier loss.

Intestinal mucosal barrier loss is responsible for the chronic and recurrent ulcerative colitis. Myosin light chain kinase (MLCK) is a potential therapeutic target of the intestinal mucosal barrier dysfunction. Here, we developed a reactive oxygen species (ROS)-sensitive hydrogel (ATG-CS-Gel) derived from a diselenide-bridged arctigenin (ATG) and chitosan (CS) conjugate, with the aims of targeting to inflamed mucosa and modulating MLCK.

Resonance-State Temperature Compensation Method for Ultrasonic Resonance Wind Speed and Direction Sensors.

To achieve high-precision wind speed and direction measurements in complex environments, a resonance-state temperature compensation method is proposed based on an ultrasonic resonance principle. This method effectively addresses the issue of sound velocity compensation errors caused by the temperature difference between the internal and external environments when using an internal temperature sensor for temperature compensation. By utilizing an adaptive resonance-state tracking model, the resonance frequency shift issues under varying conditions such as altitude, pressure, and temperature are mitigated.

Distinct lignocelluloses of plant evolution are optimally selective for complete biomass saccharification and upgrading Cd/Pb and dye adsorption via desired biosorbent assembly.

In this study, 15 plant species representing plant evolution were selected, and distinct lignocellulose compositions for largely varied biomass enzymatic saccharification were detected. By comparison, the acid-pretreated lignocellulose of rice mutant was of the highest Congo-red adsorption (298 mg/g) accounting for cellulose accessibility, leading to complete cellulose hydrolysis and high bioethanol production. By conducting oxidative-catalysis with the acid-pretreated lignocellulose of moss plant, the optimal biosorbent was generated with maximum Cd/Pb adsorption (54/118 mg/g), mainly due to half-reduced cellulose polymerization degree and raised functional groups accountable for multiple physical and chemical interactions.

Elucidating the Molecular Mechanisms and Comprehensive Effects of Sludge-Derived Plant Biostimulants on Crop Growth: Insights from Metabolomic Analysis.

The utilization of urban waste for land management plays a crucial role in reshaping material flows between human activities and the environment. Sewage sludge alkaline thermal hydrolysis (ATH) produces sludge-derived plant biostimulants (SPB), which have garnered attention due to the presence of indole-3-acetic acid. However, there remains a gap in understanding SPB's molecular-level effects and its comprehensive impact on crops throughout their growth cycle.

Integrin β6/Annexin A2 axis triggers autophagy to orchestrate hepatocellular carcinoma radioresistance.

Radiotherapy (RT) is one of the main therapies for hepatocellular carcinoma (HCC), but its effectiveness has been constrained due to the resistance effect of radiation. Thus, the factors involved in radioresistance are evaluated and the underlying molecular mechanisms are also done. In this present study, we identified Integrin β6 (ITGB6) as a potential radioresistant gene through an integrative analysis of transcriptomic profiles, proteome datasets and survival using HCC cases treated with IR.

Regulation of NLRP3 inflammasome and Caspase-3/4/11 by 2',4'-dihydroxychalcone contributes to anti-colorectal cancer.

Background: Chronic inflammation is closely related to the occurrence and progression of many cancers, especially colorectal cancer (CRC), which can be triggered by repeated and sustained induction of colitis in mice. CRC is a typical type of cancer that can be caused by inflammation and NLRP3 inflammasome dysregulation plays a certain role in the pathogenesis of CRC.

Purpose: As an edible Chinese medicine, Abrus cantoniensis Hance (ACH) has both anti-inflammatory and anti-tumor activities.

Composition and Effects of Aerosol Particles Deposited on Urban Plant Leaves in Terrestrial and Aquatic Habitats.

Plants play a vital role in mitigating aerosol particles and improving air quality. This study investigated the composition characteristics and potential effects of particles retained on the leaf surfaces of two amphibious plants (i.e.

Activation of a helper NLR by plant and bacterial TIR immune signaling.

Plant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to initiate immune signaling. TIR domains across different kingdoms have NADase activities and can produce phosphoribosyl adenosine monophosphate/diphosphate (pRib-AMP/ADP) or cyclic ADPR (cADPR) isomers. The lipase-like proteins EDS1 and PAD4 transduce immune signals from sensor TIR-NLRs to a helper NLR called ADR1, which executes immune function.

Dual optimization in anaerobic digestion of rice straw: Effects HRT and OLR coupling on methane production in one-stage and two-stage systems.

This experiment reports an energy-saving, cost-effective and environmental-friendly method to recover energy from high-cellulose waste: anaerobic digestion (AD) by extending hydraulic residence time (HRT) from 50d to 70d with ultra-high organic loading rate (OLR) of 2.28-2.80 g TS·L d.

A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.

Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing meiotic products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of them have been characterized at the molecular level, and their killing mechanisms remain largely unknown. In this study, we identify that a gene previously deemed essential for cell survival in the fission yeast is a single-gene KMD.

Mapping multiple RNA modifications simultaneously by proximity barcode sequencing.

RNA is subject to a multitude of different chemical modifications that collectively represent the epitranscriptome. Individual RNA modifications including N6-methyladenosine (mA) on mRNA play essential roles in the posttranscriptional control of gene expression. Recent technological advances have enabled the transcriptome-wide mapping of certain RNA modifications, to reveal their broad relevance and characteristic distribution patterns.

Temporal Shifts in Etiological Agents and Antibiotic Resistance Patterns of Biliary Tract Infections in Sichuan Province, China (2017-2023).

Purpose: We analyzed the pathogenic bacteria and antibiotic resistance distributions in patients with biliary tract infections (BTI) using samples from the Antimicrobial Resistant Investigation Network of Sichuan Province (ARINSP) to promote the rational use of antibiotics to reduce multidrug resistance.

Patients And Methods: Participating hospitals identified isolates between 2017 and 2023 and conducted antimicrobial susceptibility tests. Isolated bacteria were identified and tested for drug sensitivity using MOLDI-TOF mass spectrometry system, VITEK automated drug sensitivity system and paper diffusion method, and the results were interpreted with reference to CLSI M100 30th edition standards.