The Value of Whole-Volume Radiomics Machine Learning Model Based on Multiparametric MRI in Predicting Triple-Negative Breast Cancer.

Objective: This study aimed to investigate the value of radiomics analysis in the precise diagnosis of triple-negative breast cancer (TNBC) based on breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and apparent diffusion coefficient (ADC) maps.

Methods: This retrospective study included 326 patients with pathologically proven breast cancer (TNBC: 129, non-TNBC: 197). The lesions were segmented using the ITK-SNAP software, and whole-volume radiomics features were extracted using a radiomics platform.

Effects of Somatosensory Games on Heart Rate Variability and Sleep-Related Biomarkers in Menopausal Women With Poor Sleep Quality.

Background And Objectives: The aim of this study was to investigate the effects of 12-week somatosensory games on heart rate variability and sleep-related biomarkers in middle-aged women with poor sleep quality.

Research Design And Methods: Twenty-nine women with poor sleep quality were recruited as participants randomly assigned into ring fit adventure exergame group (RFA,  = 15) and control group (CON,  = 14). The RFA group received ring fit adventure exergame for 60 min each time, 2 times a week, for 12 weeks.

Liver mechanosignaling as a natural anti-hepatitis B virus mechanism.

The mechanisms underlying the natural control of hepatitis B virus (HBV) infection have long been an intriguing question. Given the wide physiological range of liver stiffness and the growing attention to the role of mechanical microenvironment in homeostasis and diseases, we investigated how physical matrix cues impact HBV replication. High matrix stiffness significantly inhibited HBV replication and activated YAP in primary hepatocyte culture system, a key molecule in mechanosignaling.

Gender and age related brain structural and functional alterations in children with autism spectrum disorder.

To explore the effects of age and gender on the brain in children with autism spectrum disorder using magnetic resonance imaging. 185 patients with autism spectrum disorder and 110 typically developing children were enrolled. In terms of gender, boys with autism spectrum disorder had increased gray matter volumes in the insula and superior frontal gyrus and decreased gray matter volumes in the inferior frontal gyrus and thalamus.

Comparison of the value of adipose tissues in abdomen and lumbar vertebra for predicting disease activity in Crohn's disease: A preliminary study based on CSE-MRI.

Background: To compare the value of adipose tissues in abdomen and lumbar vertebra for predicting Crohn's disease (CD) activity based on chemical shift encoded magnetic resonance imaging (CSE-MRI).

Methods: 84 CD patients were divided into remission, mild, and moderate-severely groups based on CD activity index (CDAI). Differences in different adipose parameters [subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), mesenteric fat index (MFI), and bone marrow fat fraction (BMFF)] and blood inflammatory indicators among three groups, as well as the correlation of above parameters and CDAI were analyzed.

Lymphocyte-related ratios in methamphetamine-induced psychotic disorder in Taiwan, comparing with patients with schizophrenia.

The lymphocyte-related ratios, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) are new measures of inflammation within the body. Few studies have investigated the inflammatory response of patients with methamphetamine-induced psychotic disorder. Clinically, the psychotic symptoms and behavioural manifestation of methamphetamine-induced psychotic disorder are often indistinguishable from paranoid schizophrenia.

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes.

Type I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection. All IFN-Is signal through a shared IFN-I heterodimeric receptor complex comprising IFN-α receptor 1 (IFNAR1) and IFNAR2 subunits, but differences in antiviral and immunomodulatory responses among IFN-I subtypes remain largely unknown. Because the IFN-IFNAR interactions are species-specific, mice exhibit weak responses to human IFN-I.

Regional homogeneity alterations in patients with functional constipation and their associations with gene expression profiles.

Functional constipation, a highly prevalent functional gastrointestinal disorder, often accompanies by mental and psychological disorders. Previous neuroimaging studies have demonstrated brain functional and structural alterations in patients with functional constipation. However, little is known about whether and how regional homogeneity is altered in these patients.

Extreme precipitation stable isotopic compositions reveal unexpected summer monsoon incursions in the Qilian Mountains.

Isotope composition and moisture sources of precipitation are important for understanding water cycles and reconstructing paleoclimate. Based on 15-years' precipitation stable Isotope composition (δO and δH) from four stations of the Qilian Mountains, we found unique δO and δH features associated with the incursion of the summer monsoon over the Qilian Mountains, northwestern China. In 12 of the 15 years, similar seasonal variations of δO and δH confirmed a dominant source of moisture from Westerly circulation, and higher intercepts of the local meteoric water line (LMWL) indicated strong recycling of continental moisture.

Notable conservation gaps for biodiversity, ecosystem services and climate change adaptation on the Tibetan Plateau, China.

Incorporating biodiversity, ecosystem services (ESs) and climate change adaptation into the conservation targets of protected areas (PAs) is being acknowledged. Targeting conservation actions requires a thorough understanding of the relationship between PAs and these important regions. However, few studies have identified conservation gaps while simultaneously considering these three aspects.

The role of nature reserves in conservation effectiveness of ecosystem services in China.

Establishing nature reserves (NRs) is a common method to avoid biodiversity loss and degradation of ecosystem services (ESs). The evaluation of ESs in NRs and the exploration of associated influencing factors are the basis for improving ESs and management. However, the ES effectiveness of NRs over time remains questionable, namely due to the heterogeneity of landscape characteristics inside and outside of NRs.

An action plan for the agri-food sector at the time of the climate and biodiversity crises.

Agriculture is responsible for about one third of global greenhouse gas emissions and it is the primary driver of habitat destruction. A paradigm shift embracing changes in lifestyles, agricultural practices, and policies is required to realize a sustainable transition in the agri-food sector.

Evaluation of left ventricular blood flow kinetic energy in patients with hypertension by four-dimensional flow cardiovascular magnetic resonance imaging: a preliminary study.

Objectives: To evaluate the intra-cavity left ventricular (LV) blood flow kinetic energy (KE) parameters using four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) in patients with hypertension (HTN).

Methods: Forty-two HTN patients and twenty age-/gender-matched healthy controls who underwent CMR including cines, pre-/post-T1 mapping, and whole-heart 4D flow imaging were retrospectively evaluated. HTN patients were further divided into two subgroups: with preserved ejection fraction (HTN-pEF) and with reduced ejection fraction (HTN-rEF).

Upgrading protected areas can improve or reverse the decline in conservation effectiveness: Evidence from the Tibetan Plateau, China.

Protected areas (PAs) are considered essential for maintaining biodiversity. Several governments would like to strengthen the management levels of their PAs (as shorthand for a hierarchy in PA administrative governance) to consolidate their conservation effectiveness. This upgrade (e.

mDIXON-Quant technique diagnostic accuracy for assessing bone mineral density in male adult population.

Background: To investigate the diagnostic efficacy of mDIXON-Quant technique for prediction of bone loss in male adults.

Methods: One hundred thirty-eight male adults were divided into normal, osteopenia, and osteoporosis groups based on DXA and QCT for the lumbar spine. Differences in mDIXON-Quant parameters [fat fraction (FF) and T2 value] among three groups, as well as the correlation of mDIXON-Quant parameters and bone mineral density (BMD) were analyzed.

Divergent effects of moderate grazing duration on carbon sequestration between temperate and alpine grasslands in China.

Moderate grazing has been widely proven to improve ecosystem functioning and have profound effects on the carbon cycling and storage in grassland ecosystems, which highly depend on grazing duration and grassland type. However, the effects of moderate grazing durations on carbon sequestration with different grassland types over broad geographic scales across China remain underexplored in the context of striving for carbon neutrality. Here, we explored the probably different responses of carbon sequestration to moderate grazing duration for temperate and alpine grasslands based on 129 published literatures regarding the China's grasslands.

Endonasal Septoplasty Using a Septal Cartilaginous Batten Graft for Managing Caudal Septal Deviation.

Caudal nasal septal deviation is an important condition altering nasal obstruction and cosmetic appearance and many surgical techniques have been published on how to correct caudal septal deviation, as successful management of caudal septal deviation is challenging. The goal of our study was to explore the effect of endonasal septoplasty using a septal cartilaginous batten graft for managing caudal septal deviation. We tested 26 participants with caudal septal deviation who received endonasal septoplasty using a septal cartilaginous batten graft from 1 April 2019 to 29 June 2022, and followed up for at least 6 months.

Achieving the Sustainable Development Goals in the post-pandemic era.

The COVID-19 pandemic continues to pose substantial challenges to achieving the Sustainable Development Goals (SDGs). Exploring systematic SDG strategies is urgently needed to aid recovery from the pandemic and reinvigorate global SDG actions. Based on available data and comprehensive analysis of the literature, this paper highlights ongoing challenges facing the SDGs, identifies the effects of COVID-19 on SDG progress, and proposes a systematic framework for promoting the achievement of SDGs in the post-pandemic era.

Plant Community Traits Respond to Grazing Exclusion Duration in Alpine Meadow and Alpine Steppe on the Tibetan Plateau.

Grazing exclusion has been a primary ecological restoration practice since the implement of "Returning Grazing Land to Grassland" program in China. However, the debates on the effectiveness of grazing exclusion have kept for decades. To date, there has been still a poor understand of vegetation restoration with grazing exclusion duration in alpine meadows and alpine steppes, limiting the sustainable management of grasslands on the Tibetan Plateau.

Risk of Infertility in Males with Obstructive Sleep Apnea: A Nationwide, Population-Based, Nested Case-Control Study.

Obstructive sleep apnea (OSA) yields intermittent hypoxia, hypercapnia, and sleep fragmentation. OSA is associated with chronic medical conditions such as cardiovascular diseases, metabolic syndrome, and neurocognitive dysfunction. However, the risk of infertility in OSA remains unclear due to limited data and lack of long-term population-based studies.

Mapping and assessment of recreation services in Qinghai-Tibet Plateau.

Recreation services are part of "Experiences" in nonmaterial nature's contribution to people (NCP). It is one of the activities most closely linked to natural landscapes and human well-being. Current research methods are mostly point-based, lacking a systematic evaluation at the regional level that integrates climate conditions and recreational resources.