Publications by authors named "Hua Jiang"
Background: Shanghai's high level of ageing has given rise to a considerable number of elderly patients with type 2 diabetes mellitus (T2DM) who are confronted with the challenge of managing multimorbidity. We aimed to determine the prevalence of multimorbidity in elderly T2DM patients in a representative Pudong New Area community and critically evaluate current guidelines' inclusiveness in addressing major comorbidities.
Methods: Through the Shanghai Health Cloud platform, we extracted medical records of residents in the Huamu community (Pudong New Area, Shanghai) to screen elderly patients with at least three outpatient visits or one hospitalisation per year between 2019 and 2022.
may cause gray mold in fruits and vegetables. Paeonol, an active component of traditional Chinese medicine, could suppress various microbial growth. However, reports on its effect on have not yet been documented.
View Article and Find Full Text PDFEmerging trends and hotspots in lung cancer-prediction models research.
Ann Med Surg (Lond)
December 2024
Objective: In recent years, lung cancer-prediction models have become popular. However, few bibliometric analyses have been performed in this field.
Methods: This study aimed to reveal the scientific output and trends in lung cancer-prediction models from a global perspective.
Article Synopsis
- - Basal cell carcinoma (BCC) of the prostate is a rare tumor that has unpredictable behavior and lacks clear treatment guidelines.
- - Some research indicates that BCC can be invasive and aggressive, highlighting the need for careful monitoring and management.
- - This study investigates the effectiveness of tislelizumab, a PD-1 inhibitor, as a potential single-agent therapy for treating advanced prostate BCC.
Objective: Intestinal ischemia-reperfusion injury (IIRI) is common in a variety of critical diseases and acute stress, and acupuncture is a promising treatment for IIRI. The aim of this study is to explore the mechanism of electroacupuncture (EA) at Zusanli (ST36) in improving IIRI from the perspective of the cholinergic anti-inflammatory pathway (CAP) and miRNA 124.
Methods: Seven groups of mice were performed: Control group, I/R group (IIRI model), EA group (I/R + EA), miRNA mimic group (I/R + EA + miRNA 124 mimic), miRNA inhibitor group (I/R + EA + miRNA 124 inhibitor), PNU group (I/R + EA + α7nAChR agonist), and MLA group (I/R + EA+ α7nAChR antagonist).
Article Synopsis
- - The study investigates the aroma of Pu-erh tea by analyzing volatile compounds from five regions in Yunnan using advanced techniques like gas chromatography-mass spectrometry (GC-MS) and headspace solid phase microextraction (HS-SPME).
- - A total of 69 aroma-active compounds were identified, with alcohols, ketones, and aldehydes being the most common, and significant differences in terpenoid enantiomers were noted.
- - Important compounds were highlighted through statistical analysis, and a KEGG pathway analysis pointed to key metabolic pathways related to aroma compounds, indicating their roles in the tea's flavor profile.
Article Synopsis
- - A systematic review and meta-analysis were conducted to determine factors affecting leptomeningeal collateral status in patients with acute ischemic stroke, analyzing 81 studies with over 17,000 participants.
- - The analysis identified that older age, male sex, hypertension, diabetes, atrial fibrillation, cardioembolic stroke, internal carotid artery occlusion, and high admission blood glucose negatively impacted collateral status.
- - The study suggests that hypertension and diabetes could be modified to improve outcomes in stroke patients, while older age and male sex are inherent risk factors that cannot be changed; further studies are recommended to explore treatment strategies.
Article Synopsis
- The study aimed to identify protein compositions in early mature milk and their relationship with maternal body mass index (BMI) during lactation.
- Researchers analyzed milk samples from 70 mothers using methods like Bradford assays and ultra-performance liquid chromatography to measure various protein concentrations.
- Findings indicated that certain proteins such as total protein, lactoferrin, and α-casein showed significant positive correlations with maternal BMI, with obese mothers having higher concentrations of total protein and α-lactalbumin compared to underweight and normal groups.
Recent studies have reported that electroacupuncture (EA) can treat osteoporosis, but most of which were based on the "kidney governing bones" theory. However, the ancient Chinese medical textbook pointed out that "Gallbladder Meridian of Foot Shaoyang" correlates with bone diseases, including osteoporosis, although the therapeutic regimens were lost after the Tang Dynasty. Here, we explored whether EA at GB points improves osteoporosis and its underlying mechanism.
View Article and Find Full Text PDFBackground: Radiographically, ground-glass nodules (GGN) and part-solid nodules (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity in their clinical manifestations, biological characteristics, and prognosis. This study aimed to explore the heterogeneity of LUAD in different radiological phenotypes and associated factors influencing tumor evolution.
Methods: We performed single-cell RNA sequencing (scRNA-seq) on tumor tissues from eight and seven cases of GGN- and PSN-LUAD, respectively, at different disease stages, including minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IAC), and metastatic lung cancer (MLC).
Background: Deep partial-thickness burns have a significant impact on both the physical and mental health of patients. Our previous study demonstrated human Umbilical Cord Mesenchymal stem cells (hUCMSCs) could enhance the healing of severe burns in small animal burn models, such as rats. Furthermore, our team has developed a deep partial-thickness burn model in Bama miniature pigs, which can be utilized for assessing drug efficacy in preclinical trials for wound healing.
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- Port-wine stains (PWS) are vascular birthmarks that can darken over time, and traditional treatments like laser therapy have mixed results and side effects.
- Hematoporphyrin Monomethyl Ether-Photodynamic Therapy (HMME-PDT) is a new approach showing promising results with fewer adverse effects by specifically targeting abnormal blood vessels.
- The review highlights the clinical effectiveness of HMME-PDT based on assessments, notes improvements in vascular lesions, and calls for further research to establish consistent treatment guidelines and long-term outcomes.
Objectives: This study aimed to investigate the nephroprotective effect of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in elderly patients with type 2 diabetes mellitus (T2DM) and hypertension based on real-world clinical data. The study aimed to provide a theoretical basis for evidence-based pharmacological treatment of chronic kidney disease in this population.
Methods: The 'Health Cloud' platform of the Shanghai Municipal Health Commission was employed to identify and screen elderly patients with T2DM and hypertension.
Objectives: The use of awake extracorporeal membrane oxygenation (ECMO, without intubation or sedation under ECMO support in patients with cardiogenic shock is growing rapidly because emerging clinical investigations indicates it may reduce morbidity associated with sedation and intubation. We systematically reviewed the efficacy of awake ECMO and provided evidence for clinical practitioners and researchers.
Design: Systematic review and trial sequential meta-analysis based on observational studies.
In eukaryotes, topologically associating domains (TADs) organize the genome into functional compartments. While TAD-like structures are common in mammals and many plants, they are challenging to detect in Arabidopsis thaliana. Here, we demonstrate that Arabidopsis PDS5 proteins play a negative role in TAD-like domain formation.
View Article and Find Full Text PDFThis study evaluated the health-promoting effects of assistive technology(AT) from a holistic health perspective with the data from the rapid Assistive Technology Assessment (rATA) survey conducted by the World Health Organization (WHO) in China in 2021. Through a generalized ordered logit regression, we found that AT mainly aids in the reduction of "severe impairment" in basic activities of daily living (BADL) and facilitates the attainment of "minimal impairment" in instrumental activities of daily living (IADL), indicating that AT at the current stage not only serves as a tool to maintain basic survival, but also plays a crucial role in promoting overall health. Further research ascertained that the effects of assistive technology on BADL and IADL bear resemblances between two age groups but differ between urban and rural residents.
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- * Research indicates that ferroptosis is crucial for defending against GBS infection in mice, with peritoneal macrophages being identified as the main cells undergoing this process.
- * IL-1β not only triggers lipid oxidation in macrophages, but it also contributes to the initiation and production of ferroptosis, highlighting its significant role in enhancing resistance against GBS infection.
Article Synopsis
- Wind power and hydrogen energy systems work well together to help the environment.
- Making hydrogen energy storage cheaper is really important so we can use hydrogen energy more.
- The best setup for using wind and hydrogen together includes different wind turbines and shows that this system can save money on energy costs.
Background: Melanoma, a significant global health concern, has shown evolving epidemiologic trends. Accurate estimation of melanoma's burden is essential for public health strategies and interventions.
Objectives: This study aims to estimate the incidence, mortality, and disability-adjusted life years for melanoma, stratified by region, gender, and age group, from 1990 to 2021.
Objective: To compare the clinical efficacy between cold reducing acupuncture combined with western medication and western medication alone for wrist joint disorder of active rheumatoid arthritis (RA) with dampness-heat obstruction.
Methods: A total of 80 patients with wrist joint disorder of active RA with dampness-heat obstruction were randomly divided into a combination group (40 cases, 3 cases dropped out) and a western medication group (40 cases, 3 cases dropped out). The western medication group was treated with methotrexate tablets, 15 mg each time, once a week.