Publications by authors named "Hua Jian Gu"
Article Synopsis
- CARMIL1 is a protein that plays a crucial role in forming actin networks and regulating cellular functions, particularly in liver cancer, where its effects on cell proliferation are being studied.
- Research indicates CARMIL1 promotes liver cancer cell growth by influencing key signaling pathways like ERK and mTOR, and its downregulation can affect their activity.
- The study found that inhibiting CARMIL1 increases liver cancer cells' sensitivity to the chemotherapy drug sorafenib, suggesting a potential treatment strategy that combines CARMIL1 suppression with sorafenib for better tumor control.
Background: Although acute graft--host disease (aGvHD) is a rare complication of liver transplantation, it is poorly understood and has an extremely high mortality rate. No standardized diagnostic criteria or treatment regimens currently exist.
Case Summary: The present study investigated the etiology, diagnosis, and treatment of aGvHD following liver transplantation.