Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte-myofibroblast transition in epidural fibrosis.

Epidural fibrosis post laminectomy is the leading cause of failed back surgery syndrome. Little is known about the role and mechanisms of adipose tissues in epidural fibrosis. Here, we found that obese patients were more likely to develop epidural fibrosis after spine surgery.

LincR-PPP2R5C regulates the PP2A signaling pathway in the macrophage-myofibroblast transition in a mouse model of epidural fibrosis.

Low back pain after spine surgery is a major complication due to excessive epidural fibrosis, which compresses the lumbar nerve. Macrophage-myofibroblast transition (MMT) promoted epidural fibrosis in a mouse laminectomy model. Previously, we demonstrated that LincR-PPP2R5C regulated CD4 + T-cell differentiation.

Constructing Grape Bunch Structure Composite Film via Hollow AgNPs Coated Cellulose Nanofibers (CNF@PDA@H-AgNPs)/CNF for Efficient Electromagnetic Shielding, Thermal Conductivity, and Strain Sensing.

Achieving high shielding effectiveness in electromagnetic shielding materials relies heavily on high conductivity, yet simultaneously enhancing the absorption loss remains a persistent challenge. Consequently, the study successfully creates efficient electromagnetic shielding composite films with a unique grape-like bunch structure of hollow nanosilver (HCAF) through layer-by-layer assembly. The utilization of poly(dopamine) (PDA) to anchor nanosilver granules (AgNPs) onto cellulose nanofibers (CNF) results in the formation of CNF@PDA@AgNPs.

The application of quantum dots in dental and oral medicine: A scoping review.

Objectives: To present an overview of quantum dots' (QDs) applications in dental and oral medicine, identify research gaps in existing relevant research, and provide insights into future research.

Data And Sources: An extensive electronic search was conducted across five databases from their inception to April 2024, complemented by a manual search. There were no restrictions regarding language or publication year.

Integrating network pharmacology and model to reveal the cardiovascular protective effects of kaempferol-3--rutinoside on heart failure.

Kaempferol-3--rutinoside (KR) has an excellent cardioprotective effect, but its mechanism of action is not clear. Network pharmacology was used to predict the signaling pathways, whereas molecular docking was used for preliminary validation of KR binding to targets. AMI model rats with ligated left anterior descending coronary arteries were established.

The impact of POSTN on tumor cell behavior and the tumor microenvironment in lung adenocarcinoma.

Background: The role of cancer-associated fibroblasts (CAFs) in modulating the anti-tumor immune response in lung adenocarcinoma (LUAD) remains elusive, primarily due to the heterogeneous nature of these cells. This heterogeneity muddles the understanding of their impact on immunotherapy effectiveness.

Methods: We utilized the LUAD single-cell dataset to precisely classify tumor cells and CAFs.

Construction and validation of a prognostic model based on oxidative stress-related genes in non-small cell lung cancer (NSCLC): predicting patient outcomes and therapy responses.

Background: Non-small cell lung cancer (NSCLC) is a significant health concern. The prognostic value of oxidative stress (OS)-related genes in NSCLC remains unclear. The study aimed to explore the prognostic significance of OS-genes in NSCLC using extensive datasets from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO).

Presynaptic terminal integrity is associated with glucose metabolism in Parkinson's disease.

Objective: To investigate the relationship of synaptic loss with glucose metabolism and dopaminergic transporters in Parkinson's disease (PD) patients.

Methods: A total of 16 patients with PD and 11 age-matched healthy controls underwent positron emission tomography (PET) with the tracers [F]SynVesT-1, a ligand for the presynaptic terminal marker synaptic vesicle protein 2 A (SV2A), and FDG. PD patients also underwent PET with the dopamine transporter (DAT) ligand [18F]FP-CIT.

PKC inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability.

Protein kinase C (PKC) regulates diverse biological functions of cancer cells and is a promising therapeutic target. However, clinical trials of PKC-targeted therapies have not yielded satisfactory results. Recent studies have also indicated a tumor-suppressive role of PKCs unclear molecular mechanisms.

Hyoid Bone Position and Upper Airway Morphology of Children With Obstructive Sleep Apnea: A Systematic Review and Meta-analysis.

The objective of this systematic review was to summarise the existing evidence regarding hyoid bone position and upper airway morphology of children with obstructive sleep apnea (OSA). Electronic searches were carried out in PubMed, Embase, Web of Science, CINAHL and WorldCat databases without any restrictions on language from inception to March 2024. The studies which compared the hyoid bone position and upper airway morphology using lateral cephalograms between children with and without OSA will be included.

The hyoid bone position and upper airway morphology among children with and without adenotonsillar hypertrophy: a cross-sectional study.

Background: Adenotonsillar hypertrophy (ATH) is a major cause of pediatric obstructive sleep apnea (OSA), potentially impacting craniofacial growth and development. Currently, whether children with ATH exhibit distinctive hyoid bone position and upper airway morphology remains uncertain. This research aimed to compare the hyoid bone position and upper airway morphology of children with and without ATH.

Selective outcome reporting among randomized controlled trials published in leading dental journals: A research-on-research study.

Objectives: To study the prevalence and manifestation of selective outcome reporting (SOR) among randomized controlled trials (RCTs) published in leading dental journals, and to explore the association between SOR and potentially related factors.

Methods: We hand-searched RCTs published in the leading dental journals between 2018 and 2023. RCTs with registrations and defined primary outcomes were included, and their relevant characteristics were extracted for analysis.

S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation.

Objective: Cognitive dysfunction is one of the major symptoms of chronic sleep deprivation (CSD). Abnormal autophagy and apoptosis are thought to be important mechanisms. S100 Calcium Binding Protein A8 (S100A8) plays a key role in autophagy and apoptosis of microglia.

Research on the health lighting scheme of university library reading room.

The quality of the indoor lighting environment in the reading space of the university library is essential for students' visual perception, emotional evaluation, and cognitive efficiency. The design of the lighting environment considering the change of natural light is one of the important development directions to improve the light environment quality of the reading room and meet the health requirements of students. This paper from the perspective of reading vision, emotion, and cognitive probes into the natural light environment lighting design, builds a reading lighting environment laboratory, using subjective evaluation, task performance, and physiological indicators of the measurement method, first analyses the weight of different indicators under different time, establish lighting environment comprehensive evaluation index I and artificial illumination and desktop illumination prediction model.

sEV-mediated lipid droplets transferred from bone marrow adipocytes promote ferroptosis and impair osteoblast function.

Osteoporosis is linked to increased bone marrow adipocyte (BMAd) proliferation, which displaces bone-forming cells and alters the local environment. The impact of BMAd lipid droplets on bone health and osteoblast function remains unclear. This study investigates the interplay between BMAd-derived lipid droplets and osteoblast functionality, focusing on ferroptosis pathways.

Industry Perspective on First-in-Human and Clinical Pharmacology Strategies to Support Clinical Development of T-Cell Engaging Bispecific Antibodies for Cancer Therapy.

T-cell-engaging bispecific antibodies (TCEs) that target tumor antigens and T cells have shown great promise in treating cancer, particularly in hematological indications. The clinical development of TCEs often involves a lengthy first-in-human (FIH) trial with many dose-escalation cohorts leading up to an early proof of concept (POC), enabling either a no-go decision or dose selection for further clinical development. Multiple factors related to the target, product, disease, and patient population influence the efficacy and safety of TCEs.