Publications by authors named "Hua Dong Yan"
Article Synopsis
- Acute-on-chronic liver disease (AoCLD) is a major cause of hospitalization in hepatology, prompting a study to better understand its characteristics for diagnosis and prognosis.
- A total of 3,375 patients were analyzed, highlighting that liver cirrhosis acute decompensation (LC-AD) is the most common type, with hepatitis B virus (HBV) being the leading cause of chronic liver disease.
- The study revealed high mortality rates associated with AoCLD subtypes, emphasizing that bacterial infections are significant precipitating factors and that timely medical intervention is crucial for improving patient outcomes.
Article Synopsis
- Liver cirrhosis (LC) significantly increases the risk of developing hepatocellular carcinoma (HCC), yet current surveillance methods for HCC in LC patients are not very effective.
- This study involved over 4,000 patients with liver cirrhosis and nearly 600 HCC cases across multiple hospitals in China, where researchers developed a screening model called PreCar Score based on cell-free DNA (cfDNA) features.
- The PreCar Score showed better sensitivity in detecting early HCC compared to traditional methods, and when combined with ultrasound (US), it further improved early detection rates, making it a promising tool for regular HCC screening in high-risk patients.
Background: Hepatocellular carcinoma (HCC) generally arises from a background of liver cirrhosis (LC). Patients with cirrhosis and suspected HCC are recommended to undergo serum biomarker tests and imaging diagnostic evaluation. However, the performance of routine diagnostic methods in detecting early HCC remains unpromising.
View Article and Find Full Text PDFThe neutrophil-to-lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90-day mortality in non-cirrhotic chronic severe hepatitis.
J Dig Dis
October 2022
Objectives: To investigate the relationship between systemic inflammatory response and short-term mortality in patients with non-cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil-to-lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet-to lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR).
Methods: Data were collected from two prospectively enrolled CATCH-LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90-day liver transplant (LT)-free mortality.
Article Synopsis
- Autoimmune liver disease (AILD) has been found to have a prevalence of 9.3% among cirrhotic patients in China suffering from acute decompensation (AD), based on a study of nearly 2,600 patients.
- The study revealed that patients with AILD experienced a significantly lower rate of acute-on-chronic liver failure (ACLF) compared to those with cirrhosis from other causes, with 28-day and 90-day mortality rates in AILD-related ACLF patients being 43.8% and 80%, respectively.
- Key risk factors for increased mortality within 90 days included total bilirubin levels, hepatic encephalopathy, and blood urea nitrogen, while the specific type of
Purpose: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful noninvasive biomarker for cancer. However, the HBV integration and mutation landscape on cfDNA remains unclear.
View Article and Find Full Text PDFBackground And Aim: Circulating levels of interleukin (IL)-6, a well-known inflammatory cytokine, are often elevated in coronavirus disease-2019 (COVID-19). Elevated IL-6 levels are also observed in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). Our study aimed to describe the association between circulating IL-6 levels and MAFLD at hospital admission with risk of severe COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- COVID-19 severity is known to worsen in diabetic patients, but this study looks at whether nondiabetic patients with metabolic dysfunction, specifically metabolic associated fatty liver disease (MAFLD), are also at greater risk.
- The research involved 130 patients (65 with MAFLD and 65 without), matched by sex and age, to determine the impact of MAFLD on the severity of COVID-19.
- Findings indicate that nondiabetic patients with MAFLD have a four-fold increased risk of experiencing severe COVID-19, especially as the number of metabolic risk factors rises, highlighting the importance for healthcare providers to be aware of this association.
Liver injury is common in patients with COVID-19, but little is known about its clinical presentation and severity in the context of liver transplant. We describe a case of COVID-19 in a patient who underwent transplant 3 years ago for hepatocellular carcinoma. The patient came to clinic with symptoms of respiratory disease; pharyngeal swabs for severe acute respiratory syndrome coronavirus 2 were positive.
View Article and Find Full Text PDFObjectives: Counseling patients with acute-on-chronic hepatitis B liver failure (ACHBLF) on their individual risk of short-term mortality is challenging. This study aimed to develop a conditional survival estimate (CSE) for predicting individualized mortality risk in ACHBLF patients.
Methods: We performed a large prospective cohort study of 278 ACHBLF patients from December 2010 to December 2013 at three participating medical centers.
Article Synopsis
- - The study aimed to evaluate how well polyethylene glycol-interferon α (PEG-IFNα) works in treating HBeAg-positive chronic hepatitis B (CHB) and to investigate the link between hepatitis B virus (HBV) genotypes and treatment effects.
- - A total of 199 CHB patients received weekly PEG-IFNα injections for 48 weeks and were monitored for changes in HBeAg levels, focusing on differences between HBV genotypes B and C.
- - Results showed that early in treatment, patients with genotype B had a significantly higher seroconversion rate of HBeAg compared to those with genotype C, but by the end of the follow-up, the rates were similar, indicating
[HBV genotype and liver histology effect of peginterferon alpha treatment of HBeAg-position chronic hepatitis B].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
June 2013
Objective: To investigate the efficacy of PEG-interferon alpha (PEG-IFN alpha) treatment of HBeAg-positive chronic hepatitis B and HBV genotypes and liver tissues effect of HBeAg seroconversion.
Methods: 54 cases confirmed by liver biopsy, genotype clear HBeAg positive chronic hepatitis B (CHB) patients according to body weight, respectively, subcutaneous injection of PEG-IFN-alpha2a 135 microg or 180 microg, or PEG-IFN-alpha2b 50 microg, 80 microg or 100 microg once weekly treatment for 48 weeks and followed for 24 weeks after discontinuation. Statistics of HBeAg seroconvertion, HBV genoty pes and liver histology e antigen seroconversion after the end of treatment.
Objective: To investigate the therapeutic efficiency of antiviral treatment with pegylated-interferon (Peg-IFN) for hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) and to explore whether liver histopathological features or other factors influence the HBeAg seroconversion treatment response.
Methods: Eighty HBeAg-positive CHB patients with diagnosis confirmed by liver puncture were treated with Peg-IFN(2a or 2b)body weight dose, once weekly). At treatment week 48, the rate of HBeAg seroconversion was determined and used to analyze the influence of liver histopathological features (liver biopsy assessment of: inflammation, graded G0 to G4; fibrosis stage, graded S0 to S4), sex, age, differential levels (pre-treatment baseline vs.
Article Synopsis
- The study compares three surgical approaches (anterior, posterior, and paraspinal) for treating thoracolumbar fractures using clinical data from 94 patients with specific fracture types.
- Findings indicate that the paraspinal approach resulted in significantly shorter operation times, less blood loss, and smaller incision lengths compared to the anterior and posterior approaches.
- The conclusion notes that while the anterior approach is effective for severe fractures, it is more complex and traumatic, whereas the posterior approach is commonly used with fewer complications.