The gut microbiota-independent virulence of noninvasive bacterial pathogen Citrobacter rodentium.

Attaching and effacing (A/E) bacterial pathogens consist of human pathogens enteropathogenic Escherichia coli, enterohemorrhagic E. coli and their murine equivalent Citrobacter rodentium (CR). Emerging evidence suggests that the complex pathogen-microbiota-host interactions are critical in conferring A/E pathogen infection-induced severe symptoms and lethality in immunocompromised hosts; however, the precise underlying mechanisms remain enigmatic.

Intelligent Fault Diagnosis of Hydraulic System Based on Multiscale One-Dimensional Convolutional Neural Networks with Multiattention Mechanism.

Hydraulic systems are critical components of mechanical equipment, and effective fault diagnosis is essential for minimizing maintenance costs and enhancing system reliability. In practical applications, data from hydraulic systems are collected with varying sampling frequencies, coupled with complex interdependencies within the data, which poses challenges for existing fault diagnosis algorithms. To solve the above problems, this paper proposes an intelligent fault diagnosis of a hydraulic system based on a multiscale one-dimensional convolution neural network with a multiattention mechanism (MA-MS1DCNN).

TTK promotes HER2 + breast cancer cell migration, apoptosis, and resistance to targeted therapy by modulating the Akt/mTOR axis.

Background: HER2 + breast cancer is a malignant neoplasm with a high degree of aggressiveness and therapeutic challenge. In recent years, studies have indicated a strong correlation between TTK and various tumors, though its role in HER2 + BRCA remains unclear.

Objectives: Studying the biological function of the TTK gene in HER2 + BRCA and its resistance to targeted therapy it provides new ideas for targeted drug research.

Measurement of economic resilience under the COVID-19 based on nighttime light remote sensing: Case of Hubei province.

This study investigates the economic resilience of cities in Hubei province during the COVID-19 pandemic, utilizing highway nighttime lights as a proxy indicator. By February 2020, the pandemic had caused a significant economic contraction in Hubei. However, by May 2021, a strong recovery was observed, with most cities experiencing growth rates of over 20%.

Ferroptosis and inflammation are modulated by the NFIL3-ACSL4 axis in sepsis associated-acute kidney injury.

Sepsis-associated acute kidney injury (SA-AKI) increases the risk of death in patients with sepsis, and its major pathological change is the death of renal tubular cells. However, the mechanism of its occurrence remains unclear. Sepsis can lead to circadian dysregulation, and the rhythm gene NFIL3 has been reported to regulate lipid metabolism.

The relationship between mental health literacy and professional psychological help-seeking behavior among Chinese college students: mediating roles of perceived social support and psychological help-seeking stigma.

Introduction: Mental health literacy is viewed as a significant factor that may facilitate an individual's pursuit of professional psychological assistance. However, it is important to explore further influencing factors that might underlie this association. This study, employing the framework of the Theory of Planned Behavior (TPB), aims to examine the relationship between mental health literacy and the behavior of seeking professional psychological help, with a focus on the potential mediating roles of perceived stigma and social support in this context.

Transoceanic ships as a source of alien dinoflagellate invasions of inland freshwater ecosystems.

Ships' ballast water and sediments have long been linked to the global transport and expansion of invasive species and thus have become a hot research topic and administrative challenge in the past decades. The relevant concerns, however, have been mainly about the ocean-to-ocean invasion and sampling practices have been almost exclusively conducted onboard. We examined and compared the dinoflagellate cysts assemblages in 49 sediment samples collected from ballast tanks of international and domestic routes ships, washing basins associated with a ship-repair yard, Jiangyin Port (PS), and the nearby area of Yangtze River (YR) during 2017-2018.

Fecal transplant from vaginally seeded infants decreases intraabdominal adiposity in mice.

Exposing C-section infants to the maternal vaginal microbiome, coined "vaginal seeding", partially restores microbial colonization. However, whether vaginal seeding decreases metabolic disease risk is unknown. Therefore, we assessed the effect of vaginal seeding of human infants on adiposity in a murine model.

Effect of Sc on the Wettability of ER5356 Welding Wires and the Porosity of Deposited Metal.

In this study, Al-Mg and Al-Mg-Sc ER5356 welding wires were adopted, and the effects of the Sc element on the wetting behavior of the molten metal and the porosity of the deposited metal were investigated. Al-Mg-Sc and Al-Mg welding wires exhibit wetting angles of 17.2 and 12.

Trends in disability in activities of daily living and instrumental activities of daily living among Chinese older adults from 2011 to 2018.

Aim: This study aimed to assess the trends in disabilities in activities of daily living (ADL) and instrumental activities of daily living (IADL) among older Chinese adults and explore the influence of multimorbidity and unhealthy behaviors on ADL/IADL disability over time.

Methods: Data were obtained from four waves (2011-2018) of the China Health and Retirement Longitudinal Study. Disability in ADL/IADL was defined as inability to perform any ADL/IADL task.

In-situ shrinkage measurement of alkali-activated materials using focused ion beam combined with environmental scanning electron microscopy.

Drying shrinkage of alkali-activated slag (AAS) has gained significant attention since the volumetric instability of this material can generate premature cracking and degrade the long-term durability of concrete structures. The unique shrinkage behavior of AAS originates mainly from the particular characteristics of its main hydrated products. However, few studies have even at-tempted to investigate the shrinkage behavior of hydrated products in AAS materials.

Quantitative label-free mass spectrometry reveals content and signaling differences between neonatal and adult platelets.

Background: Recent clinical studies have shown that transfusions of adult platelets increase morbidity and mortality in preterm infants. Neonatal platelets are hyporesponsive to agonist stimulation, and emerging evidence suggests developmental differences in platelet immune functions.

Objectives: This study was designed to compare the proteome and phosphoproteome of resting adult and neonatal platelets.

Stratification of neurogenic bladder risk in spina bifida using the urinary peptidome.

Neurogenic bladder poses a major morbidity in children with spina bifida (SB), and videourodynamic studies (VUDS) are used to stratify this risk. This small-scale pilot study utilized current mass-spectrometry-based proteomic approaches to identify peptides or proteins in urine that may differentiate children at high risk of developing renal complications from a neurogenic bladder. Twenty-two urine samples of which nine had high bladder pressure storage that put the upper urinary tract at risk, while 13 with a lower risk for renal compromise were analyzed.

Phosphoproteomics reveals content and signaling differences between neonatal and adult platelets.

Background And Objective: Recent clinical studies have shown that transfusions of adult platelets increase morbidity and mortality in preterm infants. Neonatal platelets are hyporesponsive to agonist stimulation, and emerging evidence suggests developmental differences in platelet immune functions. This study was designed to compare the proteome and phosphoproteome of resting adult and neonatal platelets.

Research on the elimination of low-concentration formaldehyde by Ag loaded onto Mn/CeO catalyst at room temperature.

Formaldehyde (HCHO) is one of the major air pollutants, and its effective removal at room temperature has proven to be a great challenge. In this study, an Ag/Mn/CeO catalyst for the catalytic oxidation of low-concentration HCHO at room temperature was prepared by a hydrothermal-calcination method. The removal performance of the Ag/Mn/CeO catalyst for HCHO was systematically studied, and its surface chemical properties and microstructure were analyzed.

[Identification of Impacts from Meteorology and Local and Transported Photochemical Generation on Ozone Trends in Changsha from 2018 to 2020].

Ozone (O) pollution in Hunan province has become the most important factor among the six common conventional pollutants (i.e., NO, SO, CO, O, PM, and PM) in the atmospheric environment.

An XGBoost approach to detect driver visual distraction based on vehicle dynamics.

Objectives: Distracted driving such as reading phone messages during driving is risky, as it increases the probability of severe crashes. This study proposes an XGBoost model for visual distraction detection based on vehicle dynamics data from a driving simulation study.

Methods: A simulated driving experiment involving thirty-six drivers was launched.

Ag-promoted Cr/MnO catalyst for catalytic oxidation of low-concentration formaldehyde at room temperature.

As one of the significant pollutants in indoor air, formaldehyde (HCHO) has attracted increasing attention due to its negative effects on human health. Thus, to reduce formaldehyde pollution, herein, an Ag-promoted Cr/MnO catalyst (Ag/Cr/MnO) was obtained a hydrothermal-calcination method, which was employed for the catalytic oxidation of low-concentration indoor HCHO (∼1 ppm) at room temperature. The Ag/Cr/MnO catalyst eliminated approximately 98.

Adsorptivity and kinetics for low concentration of gaseous formaldehyde on bamboo-based activated carbon loaded with ammonium acetate particles.

The highly promising formaldehyde (HCHO)-removing materials are essential for eliminating interior pollution to safeguard the public's health with increasing indoor HCHO contamination situations being recorded on a global scale. In the paper, bamboo charcoal (BC) was activated with boric acid to prepare bamboo-based activated carbon (BAC), and then impregnated with ammonium acetate solution to successfully develop porous adsorbent with ammonium acetate particles (N/BAC), which was applied to remove low concentration of HCHO at room temperature. The adsorption performance for HCHO was systematically investigated while the surface chemical properties and microstructure of the as-prepared adsorbents were described and analyzed.

Long-term disability in common mental disorders in Chinese community: evidence from a five-year follow-up study.

Background: Common mental disorders are general term for mental disorders with high disability rates and significant social burden. The purpose of this study was to determine the degree of long-term disability associated with common mental disorders and to interpret the relationship between common mental disorders and long-term disability.

Methods: Participants in the 2013 China Mental Health Survey were followed up by telephone between April and June 2018.

Rat offspring's microbiota composition is predominantly shaped by the postnatal maternal diet rather than prenatal diet.

This study assessed the impact of maternal diet during pregnancy versus lactation on offspring gut microbiota. Sprague-Dawley dams were fed high fat (HF) or Chow diets during pregnancy, and their male offspring were raised by a different dam consuming the same or opposite diet (Chow-Chow, Chow-HF, HF-Chow, and HF-HF). Microbiota analysis showed that maternal lactation diet, rather than pregnancy diet, determined offspring microbiota profiles at weaning.

Acoustic topological beam nonreciprocity via the rotational Doppler effect.

Reciprocity is a fundamental principle of wave physics related to time-reversal symmetry. Nonreciprocal wave behaviors have been pursued for decades because of their great scientific significance and tremendous potential applications. However, nonreciprocity devices have been based on manipulation of non-topological charge (TC) in most studies to date.