Publications by authors named "Hua Cong Deng"
Article Synopsis
- The study aimed to assess how whole fresh fruit intake affects the risk of developing type 2 diabetes (T2D) in individuals with varying glucose regulation, focusing on a large group of non-diabetic participants aged 40 and older in China.
- Over a follow-up period of 3.8 years, researchers found a significant inverse relationship between fruit consumption and diabetes risk; specifically, each additional 100 grams of fruit consumed daily corresponded to a 2.8% reduction in diabetes risk.
- Results indicated that this protective effect was most pronounced in individuals with normal glucose tolerance, while no significant association was observed in those with prediabetes.
Objective: The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.
Methods: The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.
Article Synopsis
- This study explored the link between the SAA1 gene rs12218 polymorphism and osteoporosis in postmenopausal Chinese women.
- It involved 387 osteoporosis patients and 307 healthy controls, analyzing genetic variations using PCR-RFLP to identify genotypes.
- The results showed that the TT genotype of rs12218 was significantly more prevalent in osteoporosis patients and was correlated with lipid levels and bone mineral density.
Background: Antithyroid drugs such as methimazole (MMI), the mainstay of pharmacologic therapy for Graves' disease, can provoke a variety of adverse effects. MMI-induced acute pancreatitis is very rare, being described in only a few patients and never after more than two exposures as reported here. Here, we report an 18-year-old girl with Graves' disease who developed acute pancreatitis each time she received MMI.
View Article and Find Full Text PDFAdiponectin plays an important role in atherosclerosis, but its relationship with the early initiation of atherosclerosis in diabetes mellitus is still not completely understood. In this study, we defined the role of adiponectin early in the process of atherosclerosis in hyperglycemic rats. Recombinant adenovirus expressing the full-length apM1 cDNA gene (Ad-APN) was constructed and successfully transfected into hyperglycemic rats characterized by the presentation of early atherosclerosis.
View Article and Find Full Text PDF[Study on the effect and mechanism of ascorbic acid on renal podocytes in diabetes].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
February 2008
Aim: To investigate the effect and mechanism of ascorbic acid on podocyte, last barrier of glomerular filtration, in diabetic rats.
Methods: Diabetic rats induced by streptozotocin injection intraperitoneally were treated by ascorbic acid for 5 weeks. The levels of blood glucose (BG), HbA1c, urinary albumin excretion rate (UAER) and superoxide diamutase (SOD), catalase (CAT) and malondialdehyde (MDA) in renal cortex were measured.
Objective: To evaluate the effects of recombinant adenovirus encoding human apM1 gene on proliferation and nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells (HUVECs).
Methods: Protein expression of apM1 in cell culture supernatant of HUVECs transfected with human Ad-apM1 was detected by double antibody sandwich ELISA. The effect of human adiponectin on cell proliferation was assessed by MTT assay.
[Renal protective effect and its mechanism of sodium ferulate in diabetic rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
May 2004
Objective: To study the renal protective effect of sodium ferulate (SF) and its mechanism in rats with diabetic mellitus (DM).
Methods: DM rats induced by streptozotocin were treated with SF 110 mg/kg per day for 8 weeks. The ratio of kidney weight/body weight (KW/BW), serum triglyceride (TG) and total cholesterol (TC), creatinine clearance rate (Ccr), urinary protein/24 hrs, levels of endothelin-1 (ET-1) and nitric oxide (NO) in renal cortex in rats were measured, the pathological change of kidney were observed and the expression of transforming growth factor-beta 1 (TGF-beta 1) and collagen IV (C-IV) in kidney were examined using immunohistochemical assay.
[Role of P38 mitogen-activated protein kinase in expression of P-selectin on human umbilical vein endothelial cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
May 2003
Aim: To investigate the role of P38 mitogen-activated protein kinase (P38MAPK) in expression of P-selectin on human umbilical vein endothelial cells and diabetic atherosclerosis.
Methods: Human umbilical vein endothelial cell line ECV304 were stimulated with high glucose, advanced glycosylation end products (AGE), high insulin and H(2)O(2) respectively, and then expression of phosphorylated-P38MAPK and P-selectin was detected after being pre-treated with SB203580 (P38MAPK specific inhibitor).
Results: High glucose, AGE, high insulin and H(2)O(2) could activate P38MAPK by oneself, and increased notably expression of phosphorylated-P38MAPK and P-selectin on cell line ECV304; Expression of P-selectin was inhibited significantly by SB203580.