[Mechanism of autophagy inhibition for sensitizing HeLa cell apoptosis induced by trichosanthin].

This research investigated the effect and mechanism of trichosanthin(TCS) in inducing autophagy and apoptosis of HeLa cells in cervical cancer. Two-step chromatography was used to prepare TCS. MTT assay was used to detect the inhibition effect of TCS on the proliferation of HeLa cells.

The impact and mechanism of E-commerce of agricultural products on nongrain production of cultivated land in rural China.

Improving China's grain production level is conducive to achieving the sustainable development goal of zero hunger worldwide by 2030. As an important innovation in sales channels, e-commerce of agricultural products (EAP) directly affects grain production. However, no study has directly discussed the impact and mechanism of EAP on nongrain production of cultivated land (NGPL).

Observation of orbital angular momentum from an ultrathin topological insulator metasurface.

Orbital angular momentum (OAM) existing in the vortex light beam with isolated singularities and spiral phase distribution presents significant applications in optical communications and light-field manipulation. The generation of OAM based on plasmonic metasurfaces is generally limited by the large optical loss and weak tunability of metal materials. Three-dimensional (3D) topological insulators (TIs) with insulating bulk states and topologically protected surface states allow the excitation of surface plasmons with low loss in the high-frequency region.

Middle Meningeal Artery Embolization for Nonacute Subdural Hematoma.

Background: The effect of embolization of the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.

Methods: We performed a multicenter, open-label, randomized trial in China, involving patients with symptomatic nonacute subdural hematoma with mass effect. Patients were assigned to undergo burr-hole drainage or receive nonsurgical treatment at the surgeon's discretion, and patients in each group were then randomly assigned, in a 1:1 ratio, to undergo middle meningeal artery embolization with liquid embolic material or to receive usual care.

Crescentic Glomerulonephritis and Portal Hypertension with Chronic Q Fever: A Case Report and Comprehensive Literature Review.

Q fever, an infectious zoonotic disease caused by , remains prevalent in China. Systemic infections can result in renal or hepatic complications; however, it is rare for both the kidneys and liver to be simultaneously affected. We present a case of a patient who exhibited fever, rapid deterioration in renal function, thrombocytopenia, and severe ascites.

Focal Adhesion Kinase (FAK) inhibition induces membrane accumulation of aquaporin2 (AQP2) through endocytosis inhibition and actin depolymerization in renal epithelial cells.

Cellular trafficking of the water channel aquaporin 2 (AQP2) is regulated by the actin cytoskeleton in collecting duct principal cells (PC) to maintain proper water balance in animals. Critical actin depolymerization/polymerization events are involved in both constitutive AQP2 recycling, and the pathway stimulated by vasopressin receptor signaling. Focal adhesion kinase (FAK) plays an important role in modulating the actin cytoskeleton through inhibiting small GTPases, and multiple studies have shown the involvement of FAK in insulin and cholesterol trafficking through actin regulation.

Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy.

Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired mitphagy, plays a significant role in causing synaptic damage.

Identify Non-mutational p53 Functional Deficiency in Human Cancers.

An accurate assessment of p53's functional status is critical for cancer genomic medicine. However, there is a significant challenge in identifying tumors with non-mutational p53 inactivations that are not detectable through DNA sequencing. These undetected cases are often misclassified as p53-normal, leading to inaccurate prognosis and downstream association analyses.

Nanomedicines in diagnosis and treatment of prostate cancers: an updated review.

Prostate cancer (PC) is the third most common male cancer in the world, which occurs due to various mutations leading to the loss of chromatin structure. There are multiple treatments for this type of cancer, of which chemotherapy is one of the most important. Sometimes, a combination of different treatments, such as chemotherapy, radiotherapy, and surgery, are used to prevent tumor recurrence.

Effects of Different Straw Return Modes on Soil Carbon, Nitrogen, and Greenhouse Gas Emissions in the Semiarid Maize Field.

Returning straw to the field is a crucial practice for enhancing soil quality and increasing efficient use of secondary crop products. However, maize straw has a higher carbon-to-nitrogen ratio compared to other crops. This can result in crop nitrogen loss when the straw is returned to the field.

Identification of potential pathogenic genes related to osteoporosis and osteoarthritis.

Background: Osteoarthritis (OA) and osteoporosis (OS) are the most common orthopedic diseases.

Objective: To identify important genes as biomarkers for the pathogenesis of OA and OS.

Methods: Microarray data for OA and OS were downloaded from the Gene Expression Omnibus database.

Observation of coupling interaction between surface plasmons and Tamm plasmons.

The optical effect analogous to electromagnetically induced transparency (EIT) in atomic systems has attracted broad attention in the field of photonics due to its promising applications in optical storage and integrated devices. Herein, we firstly report the experimental observation of the EIT-like effect generated from the coupling between surface plasmons (SPs) and Tamm plasmons (TPs) in a hybrid multilayer system at the near-infrared band. This multilayer system is composed of a nanofabricated silver grating on a silver/Bragg mirror with a SiO spacer.

A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH.

Time-restricted feeding (TRF) is a potent dietary intervention for improving metabolic diseases, including metabolic dysfunction-associated steatotic liver disease/metabolic dysfunction-associated steatohepatitis (MASLD/MASH). However, the mechanism of this efficacy has remained elusive. Here, we show that TRF improves MASLD, which is associated with a significant enrichment of Ruminococcus torques (R.

The therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

Objective: To explore the therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

Method: Patients with prolonged ventilator weaning and cardiac dysfunction were randomly allocated to receive conventional treatment (control group) or intravenous infusion of levosimendan for 24 h based on conventional treatment (levosimendan group). Weaning success rates were then compared between the two groups.

Recyclable Polythioesters and Poly(thioester-co-peptoid)s via Ring-Opening Cascade Polymerization of Amino Acid N-Carboxyanhydrides.

Polythioesters (PTEs) are emerging sustainable polymers for their degradability and recyclability. However, low polymerizability of monomers and extensive side reactions often hampered the polymerization process. Moreover, copolymers containing both thioester and other types of functional groups in the backbone are highly desirable but rarely accomplished owing to several synthetic challenges.

"I will resume my research work when things settle down": A narrative inquiry of an EFL academic's emotions and identities in research experiences.

Despite a surge of studies on the construction of researcher identities among English as a Foreign Language (EFL) teachers, insufficient attention has been paid to their ongoing identity development after establishing a researcher identity. Using narrative inquiry, this study investigated how an EFL academic transitioned from being a rising star in research to becoming a teaching-focused academic midcareer with emotional flux in situated socio-institutional contexts. Data were collected from semi-structured interviews, narrative frame, institutional documents, and the participant's academic profile.

A Pedigree Investigation of H-antigen Deletion Caused by Mutation of 658 C to T in the FUT1 Gene.

H-antigen deletion is often caused by FUT1 gene mutation, which is a very rare blood group. In this case, the H-antigen phenotype, FUT1, FUT2 sequences, and family genetic investigation of a 26-year-old patient (proband) and her three family members were studied. The results showed that the proband and little her brother were H-deficient phenotype, their ABO genotype of both was A/O1, her father was A/B, and her mother was O1/O1.

Nonionic Water-Soluble Oligo(ethylene glycol)-Modified Polypeptides with a β-Sheet Conformation.

The secondary structures of polypeptides, such as an α-helix and a β-sheet, often impart specific properties and functions, making the regulation of their secondary structures of great significance. Particularly, water-soluble polypeptides bearing a β-sheet conformation are rare and challenging to achieve. Here, a series of oligo(ethylene glycol)-modified lysine -carboxylic anhydrides (K-NCA, where = 1-3) and the corresponding polymers K are synthesized, with urethane bonds as the linker between the side-chain EG and lysine.

Particle-ozone complex pollution under diverse synoptic weather patterns in the Yangtze River Delta region: Synergistic relationships and the effects of meteorology and chemical compositions.

There is considerable academic interest in the particle-ozone synergistic relationship (PO) between fine particulate matter (PM) and ozone (O). Using various synoptic weather patterns (SWPs), we quantitatively assessed the variations in the PO, which is relevant to formulating policies aimed at controlling complex pollution in the air. First, based on one-year sampling data from March 2018 to February 2019, the SWPs classification of the Yangtze River Delta (YRD) was conducted using the sum-of-squares technique (SS).

Direct oral anticoagulants in the treatment of chronic thromboembolic pulmonary hypertension patients: A retrospective cohort study.

Introduction: Direct oral anticoagulants (DOACs) are increasingly prescribed for life-long anticoagulation in chronic thromboembolic pulmonary hypertension (CTEPH) patients, despite not being recommended in the guidelines. This study aims to evaluate the efficacy and safety of DOACs in CTEPH patients.

Methods: From May 2013 to December 2022, patients who were first diagnosed with CTEPH in Fuwai Hospital and started long-term anticoagulation treatment with warfarin or DOACs were retrospectively included and followed up until (1) death, (2) transition to other kinds of anticoagulants, or (3) discontinuation of anticoagulation.