Publications by authors named "Hu-Yao Ku"
Article Synopsis
- Early diagnosis of diabetic retinopathy (DR) is crucial due to its prevalence as a complication in diabetes, leading to potential vision loss and increased strain on healthcare systems.
- Current diagnostic methods are limited by their qualitative nature and reliance on individual ophthalmologists, leading to late diagnoses that hamper timely treatment.
- This study introduces an advanced optoelectrokinetic bead-based immunosensing technique for detecting lipocalin 1 (LCN1), a biomarker for DR, achieving high sensitivity with a detection limit of 110pg/mL using just 1.5μL of sample.
Bead-based immunosensing has been growing as a promising technology in the point-of-care diagnostics due to great flexibility. For dilute samples, functionalized particles can be used to collect dispersed analytes and act as carriers for particle manipulation. To realize rapid and visual immunosensing, Förster resonance energy transfer (FRET) was used herein to ensure only the diabetic biomarker, lipocalin 1, to be detected.
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