High prevalence of low bone mineral density in middle-aged adults in Shanghai: a cross-sectional study.

Purpose: To assess bone mineral density (BMD) in middle-aged individuals in Shanghai, in order to improve awareness of osteopenia and osteoporosis screening.

Methods: The clinical data of 1107 permanent residents of Shanghai aged 40-60 years were collected using a random cluster sampling method. Osteoporosis questionnaire survey and BMD test were conducted.

Case report: Significant response of alpha-fetoprotein-producing gastric cancer from combined chemotherapy and immunotherapy.

Background: Alpha-fetoprotein-producing gastric cancer (AFPGC) represents a particularly aggressive subtype of gastric carcinoma characterized by elevated rates of vascular invasion, lymphatic dissemination, hepatic metastasis, and an unfavorable clinical outcome. Treatment strategies for AFPGC have historically lacked specificity. Herein, a case is presented involving AFPGC in which the patient exhibited a notable response to combined anti-PD-1 antibody immunotherapy and SOX chemotherapy, potentially achieving a cure.

Enhancement of hybrid organohydrogels by interpenetrating crosslinking strategies for multi-source signal recognition over a wide temperature range.

With substantial temperature differentials between summer and winter in polar regions, there exists a pressing necessity for flexible sensors capable of functioning across a broad temperature spectrum to facilitate the construction of a more intelligent human-machine interface. Nevertheless, developing flexible sensors resilient to extremely low temperatures remains a significant challenge. In this study, we present an organohydrogel capable of functioning ranging from ambient to -78 °C, enabling real-time monitoring of multi-source signals, including motion, physiology, speech, and pressure.

Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment ROS scavenging and YAP1 stabilization.

Clusterzymes are synthetic enzymes exhibiting substantial catalytic activity and selectivity, which are uniquely driven by single-atom constructs. A dramatic increase in antioxidant capacity, 158 times more than natural trolox, is noted when single-atom copper is incorporated into gold-based clusterzymes to form AuCu. Considering the inflammatory and mildly acidic microenvironment characteristic of osteoarthritis (OA), pH-dependent dendritic mesoporous silica nanoparticles (DMSNs) coupled with PEG have been employed as a delivery system for the spatial-temporal release of clusterzymes within active articular regions, thereby enhancing the duration of effectiveness.

Recent advances in moisture-induced electricity generation based on wood lignocellulose: Preparation, properties, and applications.

Moisture-induced electricity generation (MEG), which can directly harvest electricity from moisture, is considered as an effective strategy for alleviating the growing energy crisis. Recently, tremendous efforts have been devoted to developing MEG active materials from wood lignocellulose (WLC) due to its excellent properties including environmental friendliness, sustainability, and biodegradability. This review comprehensively summarizes the recent advances in MEG based on WLC (wood, cellulose, lignin, and woody biochar), covering its principles, preparation, performances, and applications.

A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration.

Background: The incidence of osteochondral defects caused by trauma, arthritis or tumours is increasing annually, but progress has not been made in terms of treatment methods. Due to the heterogeneous structure and biological characteristics of cartilage and subchondral bone, the integration of osteochondral repair is still a challenge.

Results: In the present study, a novel bilayer hydrogel scaffold was designed based on anatomical characteristics to imitate superficial cartilage and subchondral bone.

Radiomics analysis using magnetic resonance imaging of bone marrow edema for diagnosing knee osteoarthritis.

This study aimed to develop and validate a bone marrow edema model using a magnetic resonance imaging-based radiomics nomogram for the diagnosis of osteoarthritis. Clinical and magnetic resonance imaging (MRI) data of 302 patients with and without osteoarthritis were retrospectively collected from April 2022 to October 2023 at Longhua Hospital affiliated with the Shanghai University of Traditional Chinese Medicine. The participants were randomly divided into two groups (a training group, n = 211 and a testing group, n = 91).

Facile fabrication of regenerated cellulose-based separators for high-performance lithium-ion batteries by regulating degrees of polymerization.

Cellulose-based separators have great application prospects in the field of lithium-ion batteries (LIBs) due to their excellent wettability and thermal stability. However, most current cellulose-based separators come from high-cost nanocellulose and bacterial cellulose. Herein, regenerated cellulose (RC) separators were prepared from dissolving pulp with different degrees of polymerization (DPs) by using the NaOH/urea/thiourea dissolution system as well as a nonsolvent-induced phase separation method.

Clinical efficacy of acupuncture therapy combined with core muscle exercises in treating patients with chronic nonspecific low back pain: a systematic review and meta-analysis of randomized controlled trials.

Introduction: This meta-analysis aimed to determine the clinical efficacy of acupuncture combined with core muscle exercises on pain and functional status in patients with chronic nonspecific low back pain.

Methods: This study followed the Preferred Reporting Items for Systematic Reviews and meta-analysis criteria for systematic reviews and meta-analyses. Randomized controlled trials published till November 2023 were searched in PubMed, Web of Science, Cochrane, Embase, China National Knowledge Infrastructure, Chinese Biomedical Literature, and Wanfang databases.

Pathological progression of osteoarthritis: a perspective on subchondral bone.

Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global aging population has led to a surge in OA cases, thereby imposing a significant socioeconomic burden. Researchers have been keenly investigating the mechanisms underlying OA.

Constructing a "micro-nano collaboration" network via disk-milling: Value-enhanced utilization of flexible temperature-resistant cellulose insulation films.

Cellulose is a sustainable natural polymer material that has found widespread application in transformers and other power equipment because of its excellent electrical and mechanical performance. However, the utility of cellulose materials has been limited by the challenge of balancing heat resistance with flexibility. On the basis of the preliminary research conducted by the research team, further proposals have been put forward for a method involving disk milling to create a "micro-nanocollaboration" network for the fabrication of flexible, high-temperature-resistant, and ultrafine fiber-based cellulose insulating films.

Selective Autophagy Receptor NBR1 Retards Nucleus Pulposus Cell Senescence by Directing the Clearance of SRBD1.

Intervertebral disc degeneration (IDD) is a prevalent degenerative disorder that closely linked to aging. Numerous studies have indicated the crucial involvement of autophagy in the development of IDD. However, the non-selective nature of autophagy substrates poses great limitations on the application of autophagy-related medications.

Facilitating mitigation of agricultural non-point source pollution and improving soil nutrient conditions: The role of low temperature co-pyrolysis biochar in nitrogen and phosphorus distribution.

The current study generated co-pyrolysis biochar by pyrolyzing rice straw and pig manure at 300 °C and subsequently applying it in a field. Co-pyrolysis biochar demonstrated superior efficiency in mitigating agricultural non-point source pollution compared to biochar derived from individual sources. Furthermore, it displayed notable capabilities in retaining and releasing nutrients, resulting in increased soil levels of total nitrogen, total phosphorus, and organic matter during the maturation stage of rice.

Early risk assessment and prediction model for osteoporosis based on traditional Chinese medicine syndromes.

Objective: To evaluate the risk factors of osteoporosis and establish a risk prediction model based on routine clinical information and traditional Chinese medicine (TCM) syndromes.

Methods: Adults aged 30-82 who lived in 12 grass-roots communities or rural towns in Shanghai, Jilin Province, and Jiangsu Province from December 2019 to January 2022 through a multi-stage sampling method were included in this study. The risk factors and risk prediction of osteoporosis in women and men were explored and established by univariate analysis and multivariate logistic regression model.

Enhancing the Accuracy of Lymph-Node-Metastasis Prediction in Gynecologic Malignancies Using Multimodal Federated Learning: Integrating CT, MRI, and PET/CT.

Gynecological malignancies, particularly lymph node metastasis, have presented a diagnostic challenge, even with traditional imaging techniques such as CT, MRI, and PET/CT. This study was conceived to explore and, subsequently, to bridge this diagnostic gap through a more holistic and innovative approach. By developing a comprehensive framework that integrates both non-image data and detailed MRI image analyses, this study harnessed the capabilities of a multimodal federated-learning model.

Copper-Loaded Nanoheterojunction Enables Superb Orthotopic Osteosarcoma Therapy via Oxidative Stress and Cell Cuproptosis.

Catalytic tumor therapy based on two-dimensional (2D) nanomaterials is a burgeoning and promising tumor therapeutic modality. However, the inefficient utilization and conversion of exogenous stimulation, single catalytic modality, and unsatisfactory therapeutic efficiency in the tumor microenvironment (TME) have seriously restricted their further application in tumor therapy. Herein, the heterogeneous carbon nitride-based nanoagent named T-HCN@CuMS was successfully developed, which dramatically improved the efficiency of the tumor therapeutic modality.

A novel salt-barrier method of preparation flexible temperature resistant full-component nanocellulose membranes.

With the simplification and diversification of separation technologies, nanocellulose membranes have become widely used as insulating materials. Recently, study of nanocellulose membrane modification has become a hot topic. However, the application of nanocellulose membrane has been limited due to their inadequate heat resistance and flexibility.

Identification of biomarkers associated with oxidative stress-related genes in postmenopausal osteoporosis.

Osteoporosis (OP) is a prevalent metabolic disease, with aging and menopause being the major risk factors. Studies have shown that nearly one-third of postmenopausal women suffer from osteoporosis. However, there is a scarcity of research on antioxidant systems for the prevention and treatment of postmenopausal osteoporosis (PM-OP).

High-throughput profiling the effects of zinc on antibiotic resistance genes in the anaerobic digestion of swine manure.

The problem of antibiotic resistance genes (ARGs) caused by heavy metals has attracted extensive attention of human beings. Zn, a widely used feed additive, has a very high residue in swine manure, but the distribution characteristics of ARGs imposed by Zn in anaerobic digestion (AD) products are not clear. In this study, the behaviour of mobile genetic elements (MGEs), bacterial community, and their association with ARGs were determined in the presence of 125 and 1250 mg L Zn in AD system of swine manure.

Effects of resistance and balance exercises for athletic ability and quality of life in people with osteoporotic vertebral fracture: Systematic review and meta-analysis of randomized control trials.

Purpose: This study aimed to use meta-analysis to determine the impact of resistance and balance training on athletic ability and quality of life for patients with osteoporotic vertebral fracture (OVF).

Methods: This study followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) criteria for systematic reviews and meta-analyzes. The PubMed, Web of science, Cochrane, Embase, and CNKI databases were searched for randomized controlled trials (RCTs) up to September 2022.

Whole exon capture sequencing for identifying mutations associated with pulmonary benign metastasising leiomyoma.

A woman in her early 20s presented with cough and fever. She had undergone an abdominal myomectomy 3 years ago for uterine leiomyoma. Chest CT and positron emission tomography-CT revealed multiple round nodules in both lungs, suggesting metastatic lesions.

Enhanced paper sludge dewatering and in-depth mechanism by oxalic acid/Fe/persulfate process.

As a typical advanced oxidation process, Fe-persulfate (PDS) oxidation technology has been widely and efficiently reported for enhancing sludge dewaterability. However, higher dosage of Fe must be added, which will restrain the oxidation efficiency of Fe-PDS process. In this work, the oxalic acid (OA)/Fe-PDS process was studied to improve paper sludge dewatering.