[Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma].

Liver cancer is a common tumor of digestive system. Hepatocellular carcinoma (HCC) is a common type of liver cancer, which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world. Metabolic reprogramming is considered to be an important marker of carcinogenesis.

Detection of virulence gene based on CRISPR strip.

Introduction: () is a prominent pathogen responsible for both hospital-acquired and community-acquired infections. Among its arsenal of virulence factors, Panton-Valentine Leucocidin (PVL) is closely associated with severe diseases such as profound skin infections and necrotizing pneumonia. Patients infected with -positive often exhibit more severe symptoms and carry a substantially higher mortality risk.

Circulating exosomal miR-16-5p and let-7e-5p are associated with bladder fibrosis of diabetic cystopathy.

Diabetic cystopathy (DCP) is a prevalent etiology of bladder dysfunction in individuals with longstanding diabetes, frequently leading to bladder interstitial fibrosis. Research investigating the initial pathological alterations of DCP is notably scarce. To comprehend the development of fibrosis and find effective biomarkers for its diagnosis, we prepared streptozotocin-induced long-term diabetic SD rats exhibiting a type 1 diabetes phenotype and bladder fibrosis in histology detection.

Application of orthokeratology on myopia control and its effect on ocular surface and meibomian gland function in Chinese myopic adolescents.

Purpose: This study aimed to investigate the influence of orthokeratology (OK) on myopia control and ocular surface and meibomian gland function in myopic adolescents.

Methods: A prospective study was conducted over a 12-month period. The subjects were classified into two groups, namely, the OK lens group and the frame glasses control group.

Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China.

Aim: To demonstrate the clinical features, the risk factors, the visual prognosis and the recurrence of cytomegalovirus (CMV) retinitis (CMVR) in HIV-negative patients.

Methods: HIV-negative patients with CMVR were involved in this study. Best corrected visual acuity (BCVA), intraocular pressure (IOP), CMV-DNA load in aqueous and/or serum samples, treatment, follow-up time, recurrence and complications were recorded.

Serum neuron-specific enolase, magnetic resonance imaging, and electrophysiology for predicting neurodevelopmental outcomes of neonates with hypoxic-ischemic encephalopathy: a prospective study.

Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity. Effective indicators for the early diagnosis of brain injury after HIE and prognosis are lacking. This study aimed to examine the predictive value of serum neuron-specific enolase (NSE), amplitude-integrated electroencephalography (aEEG), and magnetic resonance imaging (MRI), alone and in combination, for the neurological outcomes in neonates with HIE.

Clinical characteristics of ocular toxocariasis in adults in north China.

Aim: To investigate the clinical features of adult patients with ocular toxocariasis (OT) in north China and to diagnose adults OT patients in early stage.

Methods: Clinical data of 24 adults with OT were retrospectively analyzed. Slit lamp photographs and fundus photographs and other imaging examinations of all the patients were reviewed.

Neonatal myofibrillar myopathy type II associated with biallelic UNC-45B gene novel mutation and perinatal myasthenia as the core phenotype: A case report.

Myofibrillar myopathy (MFM) is characterized by phenotypic heterogeneity; decreased function of the myosin-directed chaperone, UNC-45B protein, leads to MFM II, which is characterized by slow progressive proximal myasthenia. Currently, only two studies have reported 11 cases worldwide. This study aimed to conduct genetic research and etiological analysis of a neonatal case of perinatal myasthenia who eventually died due to autonomic dyspnea.

Integrated network analysis to explore the key mRNAs and lncRNAs in acute myocardial infarction.

Acute myocardial infarction (AMI) is the most severe cardiovascular event in the world. However, the molecular mechanisms underlying AMI remained largely unclear. Recently, long non-coding RNAs (lncRNAs) were reported to play important roles in human diseases.

Identification of Key lncRNAs Associated With Atherosclerosis Progression Based on Public Datasets.

Atherosclerosis is one of the most common type of cardiovascular disease and the prime cause of mortality in the aging population worldwide. However, the detail mechanisms and special biomarkers of atherosclerosis remain to be further investigated. Lately, long non-coding RNAs (lncRNAs) has attracted much more attention than other types of ncRNAs.

Growth differentiation factor 15 is associated with left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.

Background: There is evidence suggesting that growth differentiation factor 15 (GDF-15) appears to be associated with stroke in patients with atrial fibrillation (AF). AF-related thromboembolic stroke is predominantly attributed to the thrombus from the left atrium (LA) or left atrial appendage (LAA).

Hypothesis: GDF-15 is related to LA/LAA thrombus in nonvalvular AF (NVAF) patients.

Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent.

Background And Aim: Many studies have reported that genetic variants correlate with higher risk for coronary artery disease (CAD) or in-stent restenosis (ISR) after bare metal stent (BMS) implantation. However, there is limited data assessing the impact of these variants on ISR in patients treated with drug-eluting stent (DES). The purpose of this study was to investigate the effects of genetic risk factors on ISR in Chinese Han patients treated with DES.

The mobile monitoring of black carbon and its association with roadside data in the Chinese megacity of Shanghai.

High-level black carbon (BC) pollution is associated with traffic emissions in metropolitan areas with high vehicle density. Mobile monitoring was conducted to assess the in-vehicle BC exposure on three backbone ring roads (inner, middle, and outer ring roads) on October 14 and October 18, 2015 in Shanghai. Ambient BC monitoring was also simultaneously conducted in three fixed roadside stations from October 14 to October 20, 2015.

[Optimal sequence algorithm of divided period appointment consultation service sequence for re-visiting patients in the department of stomatology].

Purpose: An optimal sequence algorithm model of divided period appointment consultation service was built through optimal sequence algorithm.

Methods: Re-visiting patients in the department of stomatology in a tertiary hospital were enrolled as the research objects in this study. Information about the diagnose term of common diseases, tooth positions treated, doctor's consultation hours were collected.

[Treatment of osteochondritis lesion in the knee with reduction and fixation under arthroscopy].

Objective: To study clinical results of reduction and fixation under arthroscopy for the treatment of osteochondrotical lesion in the knee.

Methods: From December 2012 to December 2013, 4 patients with the knee joint osteochondritis lesion and free bone fragments were treated with arthroscopy to detect the stripped cartilage, and then the cartilages were reduced with small incision and fixed by cartilage nail. There were 3 males and 1 female, with age of 15, 15, 20 and 27 years old.

Estimation of Cancer Burden Attributable to Infection in Asia.

Background: Some infectious agents have been shown to be human carcinogens. The current study focused on estimation of cancer burden attributable to infection in different regions of Asia.

Methods: By systematically reviewing previous studies of the infection prevalence data of 13 countries in Asia and relative risks of specific cancers, we calculated the population attributable fraction of carcinogenic infections.

[Population-attributable risk estimates for breast cancer in Chinese females].

Objective: To estimate the contribution of known identified risk factors to breast cancer incidence and mortality in China, and provide evidence to support the prevention and control of breast cancer for Chinese females.

Methods: We calculated the proportion of breast cancer attributable to specific risk factors. Data on exposure prevalence were obtained from Meta-analyses and large-scale national surveys of representative samples of the Chinese population.

[Screening of key genes and inflammatory signalling pathway involved in the pathogenesis of HLA-B27-associated acute anterior uveitis by gene expression microarray].

Objective: To investigate the genes and signalling pathways located upstream of the inflammatory processes in human leukocyte antigen (HLA)-B27-associated acute anterior uveitis by gene expression microarray.

Methods: Experimental study. HLA-B27-positive and-negative monocytes isolated from human peripheral blood were stimulated with Vibrio cholera lipopolysaccharide (LPS).

[Nitrate storage and transport within a typical karst aquifer system in the paralleled ridge-valley of east Sichuan].

In order to investigate the nitrate storage and transport in the karst aquifer system, the hydrochemical dynamics of Qingmuguan underground river system was monitored online by achieving high-resolution data during storm events and monthly data in normal weather. The principal component analysis was employed to analyze the karst water geochemistry. Results showed that nitrate in Jiangjia spring did not share the same source with soluble iron, manganese and aluminum, and exhibited different geochemical behaviors.

[Prelimilary Study on Manipulative Resetting Pictures of Shang ke hui zuan (Collected Compilation of Traumatology)].

Shang ke hui zuan (Collected Compilation of Traumatology) written by Hu Ting-guang, a famous doctor in the Qing Dynasty, is a comprehensive traumatology book, which records 16 manual reduction pictures with a five-word verse in each one and 9 seven-word verses in Chapter 3 supplementing the former and vice versa. Vivid pictures and brief verses matched with each other are convenient to imitate and recite, and play a vital role in promotion of inheritance and transmission of manual reduction technique on traumatology.

[Study on pictures in Waike Xinfa Yaojue].

Collecting 265 pictures, Waike Xinfa Yaojue (written in Qing Dynasty) is the extant ancient surgical book with most pictures. Pictures could be divided into four kinds, i.e.

[Ammonia volatilization of slow release compound fertilizer in different soils water conditions].

By using venting method incubation experiment, we studied the ammonia volatilization and kinetics characteristics of uncoated slowed release compound fertilizer (SRF) under different soil water conditions and the growth and nitrogen utilization efficiency of rice in pot experiment. Results indicated that the ammonia volatilization of SRF under waterflooding reached the peak ahead of 3-4 days compared to the moist treatment. The peak and accumulation of ammonia volatilization in the waterflooding treatments were higher than those under the moist condition.

[Toll-like receptor 4 expression in macrophages in endotoxin-induced uveitis in Wistar rats].

Objective: To investigate the dynamics and distribution of toll-like receptor 4 (TLR4) in uvea-resident tissue macrophages during endotoxin-induced uveitis (EIU) in Wistar rats.

Methods: Fifty Wistar rats were randomly divided into five groups (n = 10 per group) based on the following time points: before LPS injection (0 h, control group) and 6, 12, 24, and 48 h after LPS injection. All the rats (except the control group) received a footpad injection of 200 microg of vibrio cholera lipopolysaccharide (LPS).

[Taking a look at the characteristics of the diagnostic methods of Traditional Chinese Medicine (TCM) from the periodical literature in the republican period of China].

Compiling 198 pieces of literature related to TCM diagnostic method in 210 kinds of medical periodicals during the republican period of China, they can be divided into three categories by different characteristics: theoretical research, popular common sense, works and lectures etc. Taking a look at the contents of the articles, there were 74 pieces of comprehensive literature (37%) 20 pieces of inspection literatures (10%) 6 pieces of auscultation and olefaction literature (3%) 11 pieces of inquiry literature (6%) 87 pieces of palpation literature (44%) Pulse diagnosis is a traditional distinguishing diagnostic method which involves much research. The literature on pulse diagnosis was in the majority The articles about theoretical research mostly explained the TCM principles with western medical knowledge and advocated diagnosing the disease with western medical apparatus, which was the characteristic of that time.