MicroNet-MIMRF: a microbial network inference approach based on mutual information and Markov random fields.

Motivation: The human microbiome, comprises complex associations and communication networks among microbial communities, which are crucial for maintaining health. The construction of microbial networks is vital for elucidating these associations. However, existing microbial networks inference methods cannot solve the issues of zero-inflation and non-linear associations.

Dataset of Panda sperm proteome.

The giant panda (), a vulnerable species and an icon of wildlife conservation, is still at risk due to habitat fragmentation and a low reproductive rate. To further safeguard the giant panda from extinction, a captive breeding program was established in the mid 1980's, however the growth of this population has been hindered by the poor reproductive ability of captive male giant pandas. To address this, we investigated the sperm proteome of the giant panda as detailed information on sperm proteome is unavailable, as it is a highly specialized area of study.

Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF-HSF1-HSP70-1 pathway: An effective treatment for hepatocellular carcinoma.

In advanced hepatocellular carcinoma (HCC) tissues, M2-like tumor-associated macrophages (TAMs) are in the majority and promotes HCC progression. Contrary to the pro-tumor effect of M2-like TAMs, M1-like TAMs account for a small proportion and have anti-tumor effects. Since TAMs can switch from one type to another, reprogramming TAMs may be an important treatment for HCC therapy.

Physical activity as a predictor of activities of daily living in older adults: a longitudinal study in China.

Objective: This study aimed to assess the prevalence of physical activity and its association with the progression of difficulty performing activities of daily living among older adults in China.

Methods: A population-based prospective cohort study based on China Family Panel Studies (CFPS) data was conducted in 2018 and 2020. This study used a logistic model to empirically estimate the effects on daily living activities among older adults.

Known and unknown: Exosome secretion in tumor microenvironment needs more exploration.

Exosomes, extracellular vesicles originating from endosomes, were discovered in the late 1980s and their function in intercellular communication has since garnered considerable interest. Exosomes are lipid bilayer-coated vesicles that range in size from 30 to 150 nm and appear as sacs under the electron microscope. Exosome secretion is crucial for cell-to-cell contact in both normal physiology and the development and spread of tumors.

Polymeric Charge-Transporting Materials for Inverted Perovskite Solar Cells.

Inverted perovskite solar cells (PSCs) hold exceptional promise as next-generation photovoltaic technology, where both perovskite absorbers and charge-transporting materials (CTMs) play critical roles in cell performance. In recent years, polymeric CTMs have played an important role in developing efficient, stable, and large-area inverted PSCs due to their unique properties of high conductivity, tunable structures, and mechanical flexibility. This review provides a comprehensive overview of polymeric CTMs used in inverted PSCs, encompassing polymeric hole transport materials (HTMs) and electron transport materials (ETMs).

Paired Electro-Synthesis of Remote Amino Alcohols with/in HO.

Amino alcohols, particularly remote amino alcohols and peptide alcohols, are valuable due to their functional diversity in biologically active compounds. However, traditional synthesis methods face significant challenges, making electrochemistry an attractive alternative. We have developed a mild and biocompatible sequential paired electrolysis strategy, leveraging copper-electrocatalysis to synthesize diverse remote amino alcohols, including unnatural peptide alcohols.

Biosorption of cypermethrin from aqueous solutions by Pediococcus acidilactici: kinetics, isotherms, and mechanisms.

Background: Pediococcus acidilactici is an effective adsorbent for removing of pyrethroid insecticides. This study investigated the biosorption characteristics and mechanisms of P. acidilactici D15 using adsorption measurement, scanning electron microscopy, and Fourier-transform infrared spectroscopy.

Suppressed Nonreciprocal Second-Harmonic Generation of Antiferromagnet MnPSe in the MnPSe/Graphene Heterostructure Due to Interfacial Magnon-Plasmon Coupling.

Interfacial coupling is one of the keys to manipulating magnetic/nonmagnetic two-dimensional (2D) heterostructures for novel functionalities. The MnPSe/graphene heterostructure is a prospective platform for quantum information and metrology. However, how graphene affects MnPSe through interfacial coupling is still poorly understood.

Laser-based approach to measure small nuclear cross sections in plasma.

We demonstrate an approach successfully measuring very small nuclear isomeric excitation cross sections (on the order of 10 to 100 picobarns) via laser-cluster interaction. The interaction between an intense laser pulse and Kr atomic clusters generates a high-temperature and high-density plasma ball in which nuclear excitations are facilitated by inelastic electron scattering. The electron temperature reaches several hundred keV (corresponding to 10[Formula: see text] K), similar to a stellar environment.

Evaluating the drug-drug interactions of SHR4640 on repaglinide and midazolam in healthy subjects.

Background: SHR4640, a highly selective URAT1 inhibitor, was evaluated to investigate its inhibitory effects on CYP2C8 and CYP3A4 in vivo clinical trial. This study assessed the pharmacokinetic (PK) impact of SHR4640 when co-administered with the CYP2C8 probe substrate repaglinide and the CYP3A4 probe substrate midazolam.

Research Design And Methods: In this single-center, randomized, double-blind, placebo-controlled study, participants were randomly allocated in a 1:1:1 ratio to SHR4640 Group A, SHR4640 Group B, and placebo group and received oral repaglinide, midazolam, SHR4640 or placebo at specific times.

Identification of the new allele ptc1-2 and analysis of the regulatory role of PTC1 gene in rice anther development.

Anther development involves a series of important biological events that are precisely regulated by many genes. Although several important genes involved in rice anther development have been identified, the regulatory network involved in tapetal development and pollen wall formation is still largely unclear. PERSISTENT TAPETAL CELL 1 (PTC1) encodes a PHD-Finger protein, which plays a critical role in the regulation of tapetal cell death and pollen development in rice.

LSD1 deficiency in breast cancer cells promotes the formation of pre-metastatic niches.

Lysine-specific demethylase 1 (LSD1), a histone demethylating enzyme, plays a crucial role in cancer metastasis. Studies show LSD1 knockout promotes breast cancer lung metastasis, but it's unknown if it alters the lung microenvironment for metastasis. In this study, we investigated the effects of exosomes from LSD1-knockdown (LSD1 KD) breast cancer cells on pre-metastatic niche formation.

Comprehensive evaluation of the impact of whole-genome bisulfite sequencing (WGBS) on the fragmentomic characteristics of plasma cell-free DNA.

Background: Cell-free DNA (cfDNA) is non-randomly fragmented in human body fluids. Analyzing such fragmentation patterns of cfDNA holds great promise for liquid biopsy. Whole-genome bisulfite sequencing (WGBS) is widely used for cfDNA methylation profiling.

Grass Carp Reovirus (GCRV) infection activates the PERK-eIF2α pathway to promote the viral replication.

Grass carp reovirus (GCRV) belongs to the genus Aquareovirus and is responsible for causing serious hemorrhagic disease in grass carp (Ctenopharyngodon idella), characterized by high mortality rates. Numerous animal viruses have been shown to activate endoplasmic reticulum stress (ERS). However, the potential for GCRV infection to induce ERS and its implications for viral infection remain unclear.

Self-supervised Multi-scale Multi-modal Graph Pool Transformer for Sellar Region Tumor Diagnosis.

The sellar region tumor is a brain tumor that only exists in the brain sellar, which affects the central nervous system. The early diagnosis of the sellar region tumor subtypes helps clinicians better understand the best treatment and recovery of pa-tients. Magnetic resonance imaging (MRI) has proven to be an effective tool for the early detection of sellar region tumors.

Multi-scale contextual learning for medical image segmentation via dual distillation.

Background: Recently, many studies have explored fusing features extracted from Convolutional neural networks (CNNs) and transformers to integrate multi-scale representations for better performance in medical image segmentation tasks. Although these hybrid models have achieved better results than previous CNN-based and transformer-based methods, they suffer from high computation and space complexities.

Purpose: The purpose of this research is to address the prohibitive computation and space complexities of hybrid models, which limit their application in clinical practice where computational resources are usually constrained.

Application of carbon-based nanomaterials in Alzheimer's disease.

Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder marked by permanent impairment of brain function across the whole brain. This condition results in a progressive deterioration of cognitive function in patients and is frequently associated with psychological symptoms such as agitation and anxiety, imposing a significant burden on both patients and their families. Nanomaterials possess numerous distinctive physical and chemical features that render them extensively utilized.

CT-FFR by expanding coronary tree with Newton-Krylov-Schwarz method to solve the governing equations of CFD.

Aims: A new model of computational fluid dynamics (CFD)-based algorithm for coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) (CT-FFR) analysis by expanding the coronary tree to smaller-diameter lumen (0.8 mm) using Newton-Krylov-Schwarz (NKS) method to solve the three-dimensional time-dependent incompressible Navier-Stokes equations has been developed; however, the diagnostic performance of this new method has not been sufficiently investigated. The aim of this study was to determine the diagnostic performance of a novel CT-FFR technique by expanding the coronary tree in the CFD domain.