Immunogenicity, safety and consistency of seven lots of an inactivated COVID-19 vaccine in healthy children and adolescents: a randomized, double-blind, controlled, phase IV clinical trial.

Background: CoronaVac has been authorized worldwide for preventing coronavirus disease 2019. Information on the safety, immunogenicity and consistency of different lots and workshops of CoronaVac is presented here.

Methods: In this randomized, double-blind, phase IV clinical trial in healthy children and adolescents aged 3-17 years, we aimed to assess the lot-to-lot and workshop-to-workshop consistency, as well as immunogenicity and safety of seven lots of commercial-scale CoronaVac from three workshops.

Epidemiology and transmission of hepatitis A in Shaanxi (western China) after more than ten years of universal vaccination.

Background: Hepatitis A (HepA) vaccination and economic factors can change the epidemiology of HepA. In China, the implementation of free vaccination for children under 1.5 years of age in 2008 has resulted in a decline in the overall incidence of HepA.

Safety analysis of a live attenuated mumps vaccine in healthy adolescents in China: A phase 4, observational, open-label trial.

Mumps is an acute infectious disease, which was well controlled in the past, but recently it has resurged in some areas. This study aimed to evaluate the safety profile of the live attenuated mumps vaccine after large-scale vaccination. We conducted an observational, open-label phase 4 trial in Shaanxi, China from October 2020 to March 2021.

Impact of the COVID-19 pandemic on routine vaccination services in Shaanxi province, Northwest China: Non-pharmaceutical intervention period and mass COVID-19 vaccination period.

To better understand the impact of COVID-19 epidemic on routine vaccination, a cross-sectional study was carried out during non-pharmaceutical intervention period (2020) and mass COVID-19 vaccination period (2021) in Shaanxi province. Data on NIP (National Immunization Program, Free), nNIP (non-National Immunization Program, Paid), and COVID-19 vaccines inoculated and vaccination clinics were collected. At the beginning of the COVID-19 epidemic, the rate of routine vaccination clinics providing vaccination services was only 20.

Neutralizing antibody levels associated with injectable and aerosolized Ad5-nCoV boosters and BA.2 infection.

Background: Several COVID-19 vaccines are in widespread use in China. Few data exist on comparative immunogenicity of different COVID-19 vaccines given as booster doses. We aimed to assess neutralizing antibody levels raised by injectable and inhaled aerosolized recombinant adenovirus type 5 (Ad5)-vectored COVID-19 vaccine as a heterologous booster after an inactivated COVID-19 vaccine two-dose primary series.

Prognostic Biomarker SLCO4A1 Is Correlated with Tumor Immune Infiltration in Colon Adenocarcinoma.

Background: Solute carrier organic anion transporter family member 4A1 (SLCO4A1), a member of solute carrier organic anion family, is a key gene regulating bile metabolism, organic anion transport, and ABC transport. However, the association of SLCO4A1 with prognosis and tumor immune infiltration in colon adenocarcinoma (COAD) remains indistinct.

Methods: Firstly, we explored the expression level of SLCO4A1 in COAD via GEPIA, Oncomine, and UALCAN databases.

Impact of perceived supervisor support and leader-member exchange on employees' intention to leave in public sector museums: A parallel mediation approach.

High staff turnover in certain public sector organizations in Pakistan is a challenging problem, and organizations strive to reduce this issue using different mechanisms. Therefore, this research investigates the parallel mediation impact of perceived organizational support (POS) and organizational citizenship behavior (OCB) on the relationships among perceived supervisor support (PSS), leader-member exchange (LMX), and employee's intention to leave (IL). Data were collected from 482 employees working in public sector museums in Pakistan in three waves.

Seroepidemiology of Tetanus among Healthy People Aged 1-59 Years Old in Shaanxi Province, China.

The study aims to determine the seroprevalence of antibodies against tetanus among healthy people aged 1−59 years old in Shaanxi province. IgG against tetanus in serum samples were detected by ELISA. 6,439 subjects were enrolled.

Seroepidemiology of pertussis and diphtheria among healthy adults in Shaanxi Province, northwest China: A large - scale cross-sectional study.

To determine the estimated pertussis incidence in adults and the need for a booster dose by detecting pertussis and diphtheria antibody levels in adults in Shaanxi province, China. Blood samples were collected from healthy individuals aged 18-59 years in Shaanxi province in 2017. Serum immunoglobulin G (IgG) antibodies against pertussis toxin (PT) and diphtheria toxin (DT) were determined using enzyme-linked immunosorbent assay.

Synaptotagmin 1-mediated cell membrane penetration and dopamine release enhancement by latroeggtoxin-VI.

Latroeggtoxin-VI (LETX-VI), a proteinaceous neurotoxin mined from the egg transcriptome of spider L. tredecimguttatus, was previously found to promote the release of dopamine from PC12 cells. However, the relevant molecular mechanism has not been fully clear.

Preparation and characterization of attapulgite-supported phase change energy storage materials.

Phase change materials (PCMs) for the charge and discharge of thermal energy at a nearly constant temperature are of interest for thermal energy storage and management, and porous materials are usually used to support PCMs for preventing the liquid leakage and shape instability during the phase change process. Compared with commonly used polymer matrices and porous carbons, mineral materials with naturally occurring porous structures have obvious advantages such as cost-saving and abundant resources. Attapulgite (ATP) is a clay mineral with natural porous structures, which can be used to contain PCMs for thermal energy storage.

Efficiency Measurement and Heterogeneity Analysis of Chinese Cultural and Creative Industries: Based on Three-Stage Data Envelopment Analysis Modified by Stochastic Frontier Analysis.

Industry sustainability plays a vital role in shaping the environment for cultural and creative business development. However, considering the influence of the external environment and random factors on the technical efficiency (T.E.

Collaborative Innovation Network, Knowledge Base, and Technological Innovation Performance-Thinking in Response to COVID-19.

Amid the pandemic of COVID-19, the collaborative innovation network of enterprises is conducive to the sharing of innovation resources, knowledge transfer, and technology diffusion, which is closely related to the improvement of corporate technological innovation performance. Based on the patent application data of listed enterprises in Jiangsu, Zhejiang, and Shanghai in China, this study constructs a cooperation matrix, describes the characteristics of collaborative innovation network from two dimensions of network structure and network relationship, introduces the breadth of the knowledge base as a moderating variable, and analyzes the nexus between characteristics of a collaborative innovation network and technological innovation performance. Based on the panel data of 193 listed companies in Jiangsu, Zhejiang, and Shanghai, this study uses a multiple linear regression model for empirical analysis.

Implementing sequencing-based surveillance in developing countries: findings from a pilot rollout for hepatitis A in China.

Background: The emergence of SARS-Cov2 variants has highlighted the need to implement sequencing-based surveillance in developing countries for early response to mutant viruses of concern. However, limited information on how to implement sequencing-based surveillance is available, and the feasibility and performance of this new type of surveillance are still in question.

Methods: To understand the challenges with the implementation and to promote sequencing-based surveillance, we reported findings from a pilot for hepatitis A (HepA) in five sentinel provinces in China as an example of sequencing-based surveillance implementation.

Metagenomic sequencing reveals viral abundance and diversity in mosquitoes from the Shaanxi-Gansu-Ningxia region, China.

Background: Mosquitoes host and transmit numerous arthropod-borne viruses (arboviruses) that cause disease in both humans and animals. Effective surveillance of virome profiles in mosquitoes is vital to the prevention and control of mosquito-borne diseases in northwestern China, where epidemics occur frequently.

Methods: Mosquitoes were collected in the Shaanxi-Gansu-Ningxia region (Shaanxi Province, Gansu Province, and Ningxia Hui Autonomous Region) of China from June to August 2019.

"Who Champions or Mentors Others"? The Role of Personal Resources in the Perceived Organizational Politics and Job Attitudes Relationship.

Drawing insight from affective events theory, this study presents a new dimension of perceived organizational politics and job attitudes. The motivation for this study was based on the fact that perceived organizational politics affect job attitudes and that personal resources (political skill and work ethic) moderate the direct relationship between perceived organizational politics and job attitudes in the context of the higher-education sector. In this regard, the data was collected through purposive sampling from 310 faculty members from higher-education institutions in Pakistan.

Epidemiological Characteristics, Seasonal Dynamic Patterns, and Associations with Meteorological Factors of Rubella in Shaanxi Province, China, 2005-2018.

Rubella occurs worldwide, causing approximately 100,000 cases annually of congenital rubella syndrome, leading to severe birth defects. Better targeting of public health interventions is needed to achieve rubella elimination goals. To that end, we measured the epidemiological characteristics and seasonal dynamic patterns of rubella and determined its association with meteorological factors in Shaanxi Province, China.

En route to attaining a clean sustainable ecosystem: a nexus between solar energy technology, economic expansion and carbon emissions in China.

This paper probes the nexus between solar energy technology, carbon intensity of energy structures, economic expansion, and carbon emissions (CO) throughout 1990-2017 in China. The study utilized the vector auto-regressive (VAR) approach to co-integration testing and vector error-correction models to identify the most effective method for reducing CO emissions. Results from the Granger causality (GC) suggest a unidirectional causality between the variables.

Study of the Application of Deep Convolutional Neural Networks (CNNs) in Processing Sensor Data and Biomedical Images.

The fast progress in research and development of multifunctional, distributed sensor networks has brought challenges in processing data from a large number of sensors. Using deep learning methods such as convolutional neural networks (CNN), it is possible to build smarter systems to forecasting future situations as well as precisely classify large amounts of data from sensors. Multi-sensor data from atmospheric pollutants measurements that involves five criteria, with the underlying analytic model unknown, need to be categorized, so do the Diabetic Retinopathy (DR) fundus images dataset.

Structural Foundation for Insect-Selective Activity of Acylpolyamine Toxins from Spider Araneus ventricosus.

Spider venoms are insecticidal mixtures with diverse biological activities, and acylpolyamines are their small molecular active components. However, the mechanism for the insecticidal activity of acylpolyamines remains to be elucidated. Here, the structure and function of two acylpolyamine toxins, AVTX-622 and AVTX-636, from Araneus ventricosus were investigated.

Effect of allosteric molecules on structure and drug affinity of HIV-1 protease by molecular dynamics simulations.

Recent experiments show that small molecules can bind onto the allosteric sites of HIV-1 protease (PR), which provides a starting point for developing allosteric inhibitors. However, the knowledge of the effect of such binding on the structural dynamics and binding free energy of the active site inhibitor and PR is still lacking. Here, we report 200ns long molecular dynamics simulation results to gain insight into the influences of two allosteric molecules (1H-indole-6-carboxylic acid, 1F1 and 2-methylcyclohexano, 4D9).

Venom from the spider Araneus ventricosus is lethal to insects but inactive in vertebrates.

Araneus ventricosus spider venom, which was collected by electrical stimulation, is abundant in peptides and proteins with molecular weights ranging from 2 kDa to 70 kDa as determined by gel electrophoresis and mass spectrometry. Electrophysiological experiments showed that 50 μg/mL venom could block the voltage-gated sodium channels (VGSCs) currents of the dorsal unpaired median (DUM) neurons of Periplaneta americana cockroaches. However, 500 μg/mL venom could not block the VGSCs currents in rat dorsal root ganglion cells or the neuromuscular transmission in isolated mouse phrenic nerve-hemidiaphragm.

Physiological and biochemical characterization of egg extract of black widow spiders to uncover molecular basis of egg toxicity.

Background: Black widow spider (L. tredecimguttatus) has toxic components not only in the venomous glands, but also in other parts of the body and its eggs. It is biologically important to investigate the molecular basis of the egg toxicity.

Anticancer effect of total annonaceous acetogenins on hepatocarcinoma.

Objective: To confirm the anticancer effect of total annonaceous acetogenins (TAAs) abstracted from Annona squamosa Linn. on human hepatocarcinoma.

Methods: The inhibitory effect of TAAs was demonstrated in H22-bearing mice.