Bridging Three Years of Insights: Examining the Association Between Depression and Gallstone Disease.

Background: Despite sharing common pathophysiological risk factors, the relationship between gallstones and depression requires further evidence for a clearer understanding. This study combines the National Health and Nutrition Examination Survey 2017 - 2020 observational data and Mendelian randomization (MR) analysis to shed light on the potential correlation between these conditions.

Methods: By analyzing the National Health and Nutrition Examination Survey 2017 - 2020 data through weighted multivariable-adjusted logistic regression, we examined the association between depression and gallstone risk.

Isolation, purification, and structural elucidation of a water-soluble polysaccharide derived from Pilát mycelia.

This study involved the successful production of mycelial polysaccharides by optimizing submerged culture conditions of Pilát. Then, the investigation focused on the composition and chemical structure of the water-soluble polysaccharide from Pilát mycelia (PBMP) by extraction and purification. Specifically, this study indicated that a water-soluble PBMP fraction 1 (PBMP) was isolated from PBMP.

Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear.

Adeno-associated virus (AAV)-mediated gene therapy is widely applied to treat numerous hereditary diseases in animal models and humans. The specific expression of AAV-delivered transgenes driven by cell type-specific promoters should further increase the safety of gene therapy. However, current methods for screening cell type-specific promoters are labor-intensive and time-consuming.

Effects of infliximab on oxidative stress and inflammation of H9c2 cells induced by H2O2.

This study investigated the effects of infliximab (INF) on oxidative stress and inflammation in H9c2 cardiomyocytes, aiming to address the damage caused by myocardial infarction (MI). H9c2 cells were divided into three groups: control, H2O2 treatment, and H2O2+INF. Cell viability was assessed using the Cell Counting Kit-8 (CCK-8) assay.

A protocol for measuring the sexual receptivity of female Drosophila.

Female receptivity in mating is crucial for successful copulation, but protocols for quantifying female behaviors reflecting receptivity are scarce compared to the analysis of male behaviors. Here, we present a protocol for assessing the sexual receptivity of female Drosophila that considers behaviors from both sexes. We describe steps for preparing and loading flies into a courtship chamber, video recording the behaviors of the pairs, and analyzing their behavioral displays.

Dasatinib plus prednisone as induction and consolidation for adults with Ph-positive acute lymphoblastic leukaemia: A single-arm, multicentre, phase 2 trial.

To reducing chemotherapy-related toxicity, the chemo-free regimens become a new trend of Ph + ALL treatment. Therefore, we conducted a phase 2 trial of dasatinib plus prednisone, as induction (Course I) and early consolidation (Courses II and III) treating newly diagnosed Ph + ALL. The trial was registered at www.

Sex peptide regulates female receptivity through serotoninergic neurons in .

The courtship ritual is a dynamic interplay between males and females. Courtship successfully leading to copulation is determined by the intention of both parties which is conveyed by complex action sequences. In , the neural mechanisms controlling the female's willingness to mate, or sexual receptivity, have only recently become the focus of investigations.

Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin.

Mutations to the OTOF gene are among the most common reasons for auditory neuropathy. Although cochlear implants are often effective in restoring sound transduction, there are currently no biological treatments for individuals with variants of OTOF. Previous studies have reported the rescue of hearing in DFNB9 mice using OTOF gene replacement although the efficacy needs improvement.

Comprehensive analysis of fixed-time stability and energy cost for delay neural networks.

This paper focuses on comprehensive analysis of fixed-time stability and energy consumed by controller in nonlinear neural networks with time-varying delays. A sufficient condition is provided to assure fixed-time stability by developing a global composite switched controller and employing inequality techniques. Then the specific expression of the upper of energy required for achieving control is deduced.

Trade off analysis between fixed-time stabilization and energy consumption of nonlinear neural networks.

This paper concentrates on trade off analysis between fixed-time stabilization and energy consumption for a type of nonlinear neural networks (NNs). By constructing a compound switching controller and utilizing inequality techniques, a sufficient condition is proposed to ensure the fixed-time stabilization. Then, an estimate of the upper bound of the energy consumed by the controller in the control process is given.

Early Death and Survival of Patients With Acute Promyelocytic Leukemia in ATRA Plus Arsenic Era: A Population-Based Study.

Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in the real world. We conducted a population-based study of all APL patients in Zhejiang Province, China, with a total population of 82 million people, to assess the generalization of all-trans retinoic acid (ATRA) and arsenic as front-line treatment. The outcomes of APL patients were also analyzed.

Effects of lead exposure on blood electrical impedance spectroscopy of mice.

Background: Lead is a nonessential heavy metal, which can inhibit heme synthesis and has significant cytotoxic effects. Nevertheless, its effect on the electrical properties of red blood cells (RBCs) remains unclear. Consequently, this study aimed to investigate the electrical properties and the electrophysiological mechanism of lead exposure in mouse blood using Electrical Impedance Spectroscopy (EIS) in 0.

Relationship between patient safety culture and safety performance in nursing: The role of safety behaviour.

Aim: The aim of this work is to test the mediator role of patient safety behaviour between safety culture and safety performance among nurses.

Methods: This cross-sectional study was carried out between September and December 2017 in the nursing units of 10 primary hospitals, two secondary hospitals and two tertiary hospitals in Anhui Province, China.

Results: The study participants comprised 79 RNs from primary hospitals, 147 RNs from secondary hospitals and 242 RNs from tertiary hospitals.

Corrigendum: Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA.

[This corrects the article DOI: 10.3389/fbioe.2020.

Serotonin Signals Overcome Loser Mentality in .

Traumatic experiences generate stressful neurological effects in the exposed persons and animals. Previous studies have demonstrated that in many species, including , the defeated animal has a higher probability of losing subsequent fights. However, the neural basis of this "loser effect" is largely unknown.

Executive function and its relation to anatomical connectome in homosexual and heterosexual men.

Background: Sexual orientation has been suggested to affect executive function, of which the neurobiological basis is still largely unknown. In this study, we explored the interrelationship between neuropsychological characteristics in homosexual and heterosexual men and their anatomical connectome by graph theoretical analysis.

Methods: Fifty-three homosexual and 47 heterosexual males underwent diffusion tensor magnetic resonance imaging (MRI) and neuropsychological assessments.

Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA.

As a gene therapy strategy, RNA interference (RNAi) offers tremendous tumor therapy potential. However, its therapeutic efficacy is restricted by its inferior ability for targeted delivery and cellular uptake of small interfering RNA (siRNA). This study sought to develop a dual-ligand nanoparticle (NP) system loaded with siRNA to promote targeted delivery and therapeutic efficacy.

P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway.

Photodynamic therapy (PDT) is an effective oncotherapy and has been approved for clinical application. Unfortunately, its therapeutic efficacy is usually overshadowed by tumor angiogenesis. Thus, a detailed understanding of the tumor angiogenesis upon PDT is imperative.

Effects of elevated atmospheric CO concentration on photosynthsis of hybrid rice varieties in cloudy and sunny days: A FACE study.

Light and carbon dioxide (CO) are two essential components for plant photosynthesis. To understand the effects of elevated CO concentration on photosynthetic characteristics of hybrid rice under different light conditions, two hybrid rice varieties (YLY900 and YY538) were grown in the field using a free-air CO enrichment facility (FACE) in 2017 with two CO concentration treatments (ambient CO and elevated 200 μmol·mol above ambient CO), the photosynthesis traits of top full expansion leaves were measured in both sunny and cloudy days at jointing and grain filling stages. Elevated CO increased net photosynthetic rate (P) of two rice varieties.

Real-time Microwave Exposure Induces Calcium Efflux in Primary Hippocampal Neurons and Primary Cardiomyocytes.

Objective: To detect the effects of microwave on calcium levels in primary hippocampal neurons and primary cardiomyocytes by the real-time microwave exposure combined with laser scanning confocal microscopy.

Methods: The primary hippocampal neurons and primary cardiomyocytes were cultured and labeled with probes, including Fluo-4 AM, Mag-Fluo-AM, and Rhod-2, to reflect the levels of whole calcium [Ca2+], endoplasmic reticulum calcium [Ca2+]ER, and mitochondrial calcium [Ca2+]MIT, respectively. Then, the cells were exposed to a pulsed microwave of 2.

[Stable hydrogen and oxygen isotope compositions in soil-plant-atmosphere continuum (SPAC) in rocky mountain area of Beijing, China].

The stable hydrogen and oxygen isotopes are environmental isotopes, which widely exist in various kinds of water. Their relative abundance variation in water can indicate the water circulation and mechanism of water use in plant. This research selected two major kinds of greening tree species, evergreen coniferous Platycladus orientalis and deciduous broad-leaved Quercus variabilis, in Beijing mountainous area, and the water movement process in soil-plant-atmosphere continuum was investigated by the variation characteristics analysis of stable hydrogen and oxygen isotope compositions in precipitation, soil water, groundwater, plant stem water and leaf water.