Clinical diagnosis of cerebral amyloid angiopathy related hemorrhage in China: Simplified Edinburgh criteria and Boston criteria version 2.0.

Background: Accurate diagnosis of cerebral amyloid angiopathy (CAA) in surviving patients is indispensable for making treatment decisions and conducting clinical trials. We aimed to evaluate the diagnostic value and clinical utility of the simplified Edinburgh computed tomography (CT) criteria for CAA-related hemorrhage in Chinese patients.

Methods: We analyzed 212 patients with lobar hemorrhage who underwent brain CT and magnetic resonance imaging (MRI) from a multicentre cohort.

Predicting straw drinking ability of liquid foods by pipe-flow rheometry.

Designing the straw drinking experience is increasingly important in consumer-oriented liquid food innovation. The perceived 'straw drinking ease' of liquid foods could be assessed by sensory analysis. However, challenges arise in linking instrumental measurements to the subjective quantification of sensory attributes due to the complexity of perceptual behaviors in drinking.

Long-term reduced lunar mantle revealed by Chang'e-5 basalt.

The redox state of a planetary mantle affects its thermal evolution. The redox evolution of lunar mantle, however, remains unclear due to limited oxygen fugacity (fO) constraints from young lunar samples. Here, we report vanadium (V) oxybarometers on olivine and spinel conducted on 27 Chang'e-5 basalt fragments from 2.

Water and other volatiles on Mars.

This perspective reviews the recent advances in martian water and other volatiles and addresses the associated scientific questions for future martian exploration missions.

Sodium valproate inhibited apoptosis in lethally scalded rat cardiomyocytes by regulating hypoxia-inducible factor-1α expression.

This study assessed the inhibitory effect of sodium valproate (VPA) on apoptosis of cardiomyocytes in lethally scalded rats. The model of a 50% total body surface area (TBSA) third-degree full-thickness scald was produced, 48 male SD rats were randomly divided into three groups (n = 16), the sham group and the scald group were given an intraperitoneal injection of 0.25ml of saline, the scald +VPA group was given an intraperitoneal injection of VPA (300 mg/kg) after scalded, Each group was subdivided into two subgroups (n=8) according to the two observation time points of 3h and 6h after scald.

Return to the Moon: New perspectives on lunar exploration.

Lunar exploration is deemed crucial for uncovering the origins of the Earth-Moon system and is the first step for advancing humanity's exploration of deep space. Over the past decade, the Chinese Lunar Exploration Program (CLEP), also known as the Chang'e (CE) Project, has achieved remarkable milestones. It has successfully developed and demonstrated the engineering capability required to reach and return from the lunar surface.

Internal standard optimization advances sensitivity and robustness of ratiometric detection method.

We design a -aminothiophenol (pATP) modified Au/ITO chip to determine nitrite ions in lake water by a ratiometric surface-enhanced Raman scattering (SERS) method based on nitrite ions triggering the transformation of pATP to ,'-dimercaptoazobenzene (DMAB). Intriguingly, by using the SERS peak (at 1008 cm) from benzoic ring deforming as an internal standard instead of the traditional peak at 1080 cm, the detection sensitivity of the method was improved 10 times.

Utilizing systematic Mendelian randomization to identify potential therapeutic targets for mania.

Background: Mania has caused incalculable economic losses for patients, their families, and even society, but there is currently no effective treatment plan for this disease without side effects.

Methods: Using bioinformatics and Mendelian randomization methods, potential drug target genes and key substances associated with mania were explored at the mRNA level. We used the chip expression profile from the GEO database to screen differential genes and used the eQTL and mania GWAS data from the IEU database for two-sample Mendelian randomization (MR) to determine core genes by colocalization.

Identification and validation of cortisol-related hub biomarkers and the related pathogenesis of biomarkers in Ischemic Stroke.

Background: Ischemic stroke is a disease in which cerebral blood flow is blocked due to various reasons, leading to ischemia, hypoxia, softening, and even necrosis of brain tissues. The level of cortisol is related to the occurrence and progression of ischemic stroke. However, the mechanism governing their interrelationship is still unclear.

First classification of iron meteorite fragment preserved in Chang'e-5 lunar soils.

Lunar soil preserves numerous fragments of meteorites impacting on the Moon, providing a unique opportunity to investigate the distribution of the types of projectiles over billions of years. Here we report the first discovery of an iron meteorite fragment from the Chang'e-5 lunar soil, which consists mainly of martensite (quenched from taenite), kamacite, and schreibersite, with a trace of pentlandite. The meteorite fragment is Ni- and P-rich, S-poor, and based on its mineral chemistry and bulk composition, can be classified into the IID-group, a rare and carbonaceous group of iron meteorite originating in the outer Solar System.

Oscillatory rheometry for elucidating the influence of non-network biopolymer aggregation on pectin-gelatin composite gels.

Gel networks formed from biopolymers have intrigued rheological interest, especially in the food industry. Despite ubiquitous non-network biopolymer aggregation in real gel food systems, its fundamental rheological implications remain less understood. This study addresses this by preparing pectin-gelatin composite gels with dispersed or aggregated biopolymers and comparatively analyzing viscoelastic responses using rheometry.

Efficacy of multi-slice spiral computed tomography in evaluating gastric cancer recurrence after endoscopic submucosal dissection.

Background: Recurrence is the major challenge facing endoscopic submucosal dissection (ESD)-based treatment therapies for early gastric cancer (EGC). Urgent development of simple and easy surveillance approaches will enhance clinical treatment of the disease.

Aim: To explore the role of computed tomography (CT) recurrence in evaluating EGC after ESD treatment.

Synthesis of NiMoO/NiMo@NiS Nanorods for Efficient Hydrogen Evolution Reactions in Electrocatalysts.

As traditional energy structures transition to new sources, hydrogen is receiving significant research attention owing to its potential as a clean energy source. The most significant problem with electrochemical hydrogen evolution is the need for highly efficient catalysts to drive the overpotential required to generate hydrogen gas by electrolyzing water. Experiments have shown that the addition of appropriate materials can reduce the energy required for hydrogen production by electrolysis of water and enable it to play a greater catalytic role in these evolution reactions.

analysis of surface composition and meteorology at the Zhurong landing site on Mars.

The Zhurong rover of the Tianwen-1 mission landed in southern Utopia Planitia, providing a unique window into the evolutionary history of the Martian lowlands. During its first 110 sols, Zhurong investigated and categorized surface targets into igneous rocks, lithified duricrusts, cemented duricrusts, soils and sands. The lithified duricrusts, analysed by using laser-induced breakdown spectroscopy onboard Zhurong, show elevated water contents and distinct compositions from those of igneous rocks.

Reactive Hydrogel Patch for SERS Detection of Environmental Formaldehyde.

The tobacco epidemic is a public health threat that has taken a heavy toll of lives around the globe each year. As one of the poison species from smoking, formaldehyde (FA) affects both the smokers and nearby persons who are exposed to second-hand smoke. Therefore, on-site tracking of FA exposure could evaluate the public environmental safety and mitigate the potential hazards.

Study on an Animal Model of Seawater Immersion Injury Following Hemorrhagic Shock.

Introduction: To establish an animal model of delayed intravenous resuscitation following seawater immersion after hemorrhagic shock (HS).

Methods: Adult male SD rats were randomly divided into three groups: group NI (HS with no immersion), group SI (HS with skin immersion), and group VI (HS with visceral immersion). Controlled HS in rats was induced by withdrawing 45% of the calculated total blood volume within 30 min.

Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.

Purpose: Patients diagnosed with cancer often suffer from emotional stressors, such as anxiety, depression, and fear of death. However, whether fear stress could influence the glioma progression is still unclear.

Methods: Xenograft glioma animal models were established in nude mice.

MnO coated Au nanoparticles advance SERS detection of cellular glutathione.

Glutathione, referred to as GSH, abnormal physiologic level of GSH is an indication to some neurodegenerative diseases and cancers. A measurement of cellular GSH calls for rapid, sensitive, and selective methods. In this work, we rationally design and prepare Au@MnO core-shell composite nanoparticles combining with tetramethylbenzidine (TMB) molecules to determine intracellular GSH by Surface enhanced Raman scattering (SERS) technique.

SERS determination of dopamine using metal-organic frameworks decorated with Ag/Au noble metal nanoparticle composite after azo derivatization with p-aminothiophenol.

A specific surface-enhanced Raman scattering (SERS) assay for dopamine (DA) based on an azo derivatization reaction is proposed for the first time by preparation of p-aminothiophenol (PATP)-modified composite SERS substrate, composed of metal-organic framework (MIL-101) decorated with Au and Ag nanoparticles. As the result, the SERS method for detection of the azo reaction between PATP and DA exhibits superior sensitivity, selectivity, and stability. A reasonable linearity in the range 10 to 10 mol∙L is achieved, and the limit of detection is 1.

Visual Health Analysis of Print Advertising Graphic Design Based on Image Segmentation and Few-Shot Learning.

Graphics innovation must adapt to the changing trends of the times in order to stay ahead of the curve. This article investigates the use of graphic vision in print advertising design, using image segmentation as a starting point and examines the current state of visual innovation in print advertising graphic design and its various expressions and applications. A series of homogeneous regions are generated and outlined using an image segmentation algorithm based on adaptive local threshold.

In situ detection of water on the Moon by the Chang'E-5 lander.

We report analysis results of the reflectance spectra (0.48 to 3.2 μm) acquired by the Chang’E-5 lander, which provides vital context of the returned samples from the Northern Oceanus Procellarum of the Moon.

A dry lunar mantle reservoir for young mare basalts of Chang'e-5.

The distribution of water in the Moon's interior carries implications for the origin of the Moon, the crystallization of the lunar magma ocean and the duration of lunar volcanism. The Chang'e-5 mission returned some of the youngest mare basalt samples reported so far, dated at 2.0 billion years ago (Ga), from the northwestern Procellarum KREEP Terrane, providing a probe into the spatiotemporal evolution of lunar water.

Proteomics Investigation of the Time Course Responses of RAW264.7 Macrophages to Infections With the Wild-Type and Twin-Arginine Translocation Mutant Strains of .

, a notorious intracellular pathogen, causes chronic infections in many mammals, including humans. The twin-arginine translocation (Tat) pathway transports folded proteins across the cytoplasmic membrane; protein substrates translocated by include ABC transporters, oxidoreductases, and cell envelope biosynthesis proteins. Previously, we showed that a Tat mutant of M28 exhibits reduced survival within murine macrophages.

Research on International Cooperative Governance of the COVID-19.

Since the first case of the novel coronavirus (SARS-CoV-2) was reported in Wuhan, China, in December 2019, the coronavirus disease (COVID-19) has quickly spread to all the corners of the world. Amid the global public health threats posed by the COVID-19 pandemic, active cooperative governance has gradually emerged as the most powerful weapon against its spread. To facilitate international cooperation for pandemic governance, this paper applied the evolutionary game theory to analyze the factors influencing active cooperative governance and, based on the results, proposed a series of recommendations for promoting international cooperation.