Invasive cancer and spontaneous regression two weeks after papillomavirus infection.

Development of invasive cancer in mammals is thought to require months or years after initial events such as mutation or viral infection. Rarely, invasive cancers regress spontaneously. We show that cancers can develop and regress on a timescale of weeks, not months or years.

Cryptococcosis in wait-listed liver transplant candidates: Prevalence, manifestations, and risk factors.

Background: Liver cirrhosis compromises immunity against cryptococcosis, and liver transplant recipients tend to develop the disease earlier after transplantation, possibly due to unrecognized pretransplant infection. We assessed the prevalence and characteristics of cryptococcosis among liver transplant candidates and whether pre-transplant cryptococcal antigen (CrAg) can detect the disease before transplantation.

Methods: We retrospectively included liver transplant candidates in a tertiary hospital during 2017-2022.

Prediction on the chin advancement of the twin block functional appliance in growing Chinese patients using the cephalometric markers: a retrospective study.

In spite of the widespread use of functional appliances, broad variations were applied the treatment response. The aim of this study is to investigate the pre-treatment cephalometric predictors on the chin advancement of twin-block in growing Chinese patients with class II malocclusion. After screening, 90 patients treated by twin-block were included in the study.

Metabolomics combined with network pharmacology reveals the protective effect of astragaloside IV on alcoholic liver disease.

Background: Alcoholic liver disease (ALD) is a significant contributor to liver damage. However, the clinical options for the treatment of ALD are limited. Astragaloside IV (AST-IV) is a saponin isolated from Astragalus membranaceus (AM).

Joint effects of tobacco smoke exposure and heavy metals on serum sex hormones in adult males.

Objective: This study aimed to explore the associations of tobacco smoke exposure (TSE) and heavy metal exposure on sex hormones and the joint effects between them in adult males.

Methods: The study used data of 2244 adult males from the National Health and Nutrition Examination Survey (NHANES, 2013-2016). Weighted linear regression models were used to calculate their beta (β) coefficients and corresponding confidence interval (95% CI), which assessed the joint effects of TSE and heavy metals on sex hormones.

Global research trends in transcranial magnetic stimulation for stroke (1994-2023): promising, yet requiring further practice.

Background: Scholars have been committed to investigating stroke rehabilitation strategies over many years. Since its invention, transcranial magnetic stimulation (TMS) has been increasingly employed in contemporary stroke rehabilitation research. Evidence has shown the significant potential of TMS in stroke research and treatment.

Clinical application of prone position to suppress respiratory movement artifacts in supine position during magnetic resonance cholangiopancreatography/MRI.

Purpose: To compare the image quality of magnetic resonance cholangiopancreatography (MRCP) in the supine position and prone position under the conditions of the same equipment, the same sequence (3D Navigator Triggered Sampling Perfection with Application-Optimized Contrast Using Different Flip-angle Evolutions, 3D-NT-SPACE) and the same patient, and to explore the clinical application value of prone position in MRCP examination to suppress respiratory motion artifacts.

Methods: 53 participants who underwent MRCP in our hospital from April 2020 to August 2022 were prospectively collected. The 3D-NT-SPACE sequence was used in these patients.

Effects of Digital Picture Books on Young Children Undergoing Cardiac Catheterisation and Their Family Caregivers: A Randomised Controlled Trial.

Aim: To assess the impact of digital picture books on preoperative anxiety, pain and sleep quality in young children undergoing cardiac catheterisation and the anxiety of their family caregivers.

Design: A randomised, single-blinded, two-arm, parallel-group controlled trial.

Methods: Participants are young children aged 2-7 years with congenital heart disease scheduled for cardiac catheterisation and their family caregivers.

The WFS1-ZnT3-Zn Axis Regulates the Vicious Cycle of Obesity and Depression.

Obesity, a growing global health concern, is closely linked to depression. However, the neural mechanism of association between obesity and depression remains poorly understood. In this study, neural-specific WFS1 deficiency exacerbates the vicious cycle of obesity and depression in mice fed a high-fat diet (HFD), positioning WFS1 as a crucial factor in this cycle.

IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth.

Indoleamine 2,3-dioxygenase 1 (IDO1) is an immune checkpoint that degrades L-tryptophan to kynurenine (Kyn) and enhance immunosuppression, which can be an attractive target for treating colon cancer. IDO1 inhibitors have limited efficacy when used as monotherapies, and their combination approach has been shown to provide synergistic benefits. Many studies have shown that targeting chemokines can promote the efficacy of immune checkpoint inhibitors.

Frontier system-on-chip (SoC) technology for microwave diagnostics (invited).

The next generation of fusion reactors, exemplified by projects such as the Demonstration Power Plant following the International Thermonuclear Experimental Reactor, faces the monumental challenge of proving the viability of generating electricity through thermonuclear fusion. This pursuit introduces heightened complexities in diagnostic methodologies, particularly in microwave-based diagnostics. The increased neutron fluence necessitates significant reductions in vessel penetrations and the elimination of internal diagnostics, posing substantial challenges.

Soil pH enhancement and alterations in nutrient and Bacterial Community profiles following Pleioblastus amarus expansion in tea plantations.

Background: The expansion of bamboo forests increases environmental heterogeneity in tea plantation ecosystems, affecting soil properties and microbial communities. Understanding these impacts is essential for developing sustainable bamboo management and maintaining ecological balance in tea plantations.

Methods: We studied the effect of the continuous expansion of Pleioblastus amarus into tea plantations, by establishing five plot types: pure P.

Symptom experiences and self-management strategies of patients with haematological malignancy undergoing chemotherapy: A qualitative study.

Objective: To explore symptom experiences and self-management strategies from the haematological malignancy patient's perspective.

Methods: A qualitative descriptive approach was used to provide a direct and comprehensive understanding of the symptoms experienced and self-management strategies during treatment among patients with haematological malignancy. Fourteen patients with haematologic malignancies who received chemotherapy at a Chinese tertiary hospital were selected using purposeful sampling.

Sustainable chitin-derived elastomers via grafting strategy with tunable mechanical and adhesion properties.

With increasing environmental awareness and the pursuit of sustainable development goals, environmentally friendly sustainable thermoplastic elastomers (TPEs) derived from natural resources are highly desired to replace traditional TPEs. However, preparing sustainable TPEs with high mechanical properties and multifunctionality from biobased feedstocks remains a significant challenge. In this work, a series of chitin-graft-poly(acrylamide-co-2-ethylhexyl acrylate) (Chitin-g-P(AM-co-EHA)) copolymers were synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization.