Publications by authors named "Hu Haitao"

Integrating single-cell datasets from multiple studies provides a cost-effective way to build comprehensive cell atlases, granting deeper insights into cellular characteristics across diverse biological systems. However, current data integration methods struggle with interference in partially overlapping datasets and varying annotation granularities. Here, a multiselective adversarial network is introduced for the first time and present UniMap, which functions as a "discerner" to identify and exclude interfering cells from various data sources during dataset integration.

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Metal-organic frameworks (MOFs) are considered promising candidates for anode materials in Li-ion batteries (LIBs) owing to their designable structure, abundant active sites, and well-organized porosity. However, the structural factors governing active site utilization and Li-ion storage kinetics remain inadequately understood. In particular, the Li-ion storage behaviors of aromatic rings with high LUMO energy levels and situated in varying chemical environments remain a highly debated issue.

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Hepatic ischemia-reperfusion injury (IRI) is an important factor affecting the prognosis of patients undergoing surgery. Exosomes derived from mesenchymal stem cells (MSC-EXOs) are widely used and play a therapeutic role in hepatic IRI. However, natural exosomes lack liver-targeting ability and have low bioavailability.

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Objective: To systematically evaluate the safety and efficacy of SAC compared to non-SAC in the treatment of RIA, integrating evidence from high-quality studies to guide clinical practice.

Methods: A meta-analysis was conducted to compare SAC with coiling alone and BAC in the treatment of RIA. Primary outcomes were immediate and follow-up aneurysm occlusion rates, along with perioperative hemorrhagic and ischemic complication rates.

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Article Synopsis
  • - The Chinese government aims to boost the five-year cancer survival rate by 15% by 2030, emphasizing the need for better medical knowledge and public awareness about cancer prevention and treatment.
  • - A survey conducted from January to May 2023 collected responses from 2,711 participants across various groups, indicating that many medical professionals and the public are engaged in learning about cancer health, but face significant challenges such as time constraints and misinformation.
  • - While there is a strong interest in cancer education among both healthcare providers and the public, there is a pressing need for improved quality and accuracy of information in cancer prevention and treatment resources.
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Hepatocellular carcinoma (HCC) is a highly malignant tumor that is resistant to chemotherapy and immunotherapy. Icaritin (ICT), a traditional Chinese medicine, has been reported as an immunoregulatory agent for treating advanced unresectable HCC. ICT induces mitophagy to cause immunogenic cell death (ICD); however, the poor bioavailability of ICT limits its therapeutic efficacy and clinical use.

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  • Clostridium difficile infection (CDI) poses a significant public health risk, with few prevention methods available.* -
  • Researchers developed a multivalent mRNA-lipid nanoparticle vaccine that stimulates strong immune responses in various animal models, unaffected by gut microbiota changes.* -
  • The vaccine effectively protects mice from severe CDI and enhances the elimination of harmful bacteria from the gut, highlighting mRNA-LNP technology as a potential new treatment avenue.*
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Biomass-derived carbon quantum dots (CQDs) have the advantage of being green and low-cost, but their complex structure makes the study of their formation mechanism encounter a bottleneck. Lignin-derived CQDs were prepared by a two-step process of "low-temperature liquid depolymerization" coupled with "hydrothermal reaction" in a mild organic acid system. In the first step of the low-temperature acidolysis process, the lignin polymer first undergoes deethering and depolymerization reactions.

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  • First-generation COVID-19 vaccines based on the spike (S) protein have decreased in effectiveness against new Omicron variants, highlighting the need for more broadly protective vaccines.
  • Researchers developed a new mRNA vaccine targeting the nucleocapsid (N) protein and tested its efficacy alone and in combination with the existing S-based vaccine in hamsters.
  • Results showed that the combined mRNA vaccines (mRNA-S+N) provided complete protection against Omicron variants, suggesting their potential as a comprehensive COVID-19 vaccine.
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Three-dimensional-printed silicone rubber foams, with their designable and highly ordered pore structures, have shown exceptional potential for engineering applications, particularly in areas requiring energy absorption and cushioning. However, optimizing the mechanical properties of these foams through structural design remains a significant challenge. This study addresses this challenge by formulating the research question: How do different 3D-printed topologies and printing parameters affect the mechanical properties of silicone rubber foams, and how can we design a novel topological structure? To answer this, we explored the mechanical behavior of two common structures-simple cubic (SC) and face-centered tetragonal (FCT)-by varying printing parameters such as filament spacing, filament diameter, and layer height.

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Tyrosol is a natural phenolic compound with antioxidant, anti-inflammatory and other biological activities, serving as an important precursor of high-value products such as hydroxytyrosol and salidroside. Therefore, the green and efficient biosynthesis of tyrosol and its derivatives has become a research hotspot in recent years. Building cell factories by metabolic engineering of microorganisms is a potential industrial production way, which has low costs and environmental friendliness.

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Asymmetric micro-supercapacitors (MSCs) exhibit higher energy density while face significant challenges in power density as well as cycling life and large dimensions. The key factors contributing to these dilemmas include the match of electrode materials and electrolytes, poor uniformity of device, and complicated while low-precise fabrication processes. Herein we develop a laser scribing-engraving (LSE) strategy to fabricate MSCs with monolithic high-voltage output and scalable array integration.

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Background And Objective: Diabetic foot (DF) complications often lead to severe vascular issues. This study investigated the effectiveness of enhanced external counterpulsation (EECP) and its derived innovative compression strategies in addressing poor perfusion in DF. Although developing non-invasive and efficient treatment methods for DF is critical, the hemodynamic alterations during EECP remain underexplored despite promising outcomes in microcirculation.

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Dysregulated host immune responses contribute to disease severity and worsened prognosis in COVID-19 infection and the underlying mechanisms are not fully understood. In this study, we observed that IL-33, a damage-associated molecular pattern molecule, is significantly increased in COVID-19 patients and in SARS-CoV-2-infected mice. Using IL-33 mice, we demonstrated that IL-33 deficiency resulted in significant decreases in bodyweight loss, tissue viral burdens, and lung pathology.

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Article Synopsis
  • * Researchers studied the effects of pre-existing immunity from related viruses like dengue (DENV) and Zika (ZIKV) on YFV infection using a mouse model.
  • * Findings indicate that immunity from DENV-2 and ZIKV can significantly reduce YFV levels in mice, mostly through humoral immune responses, suggesting a need to reevaluate YFV outbreak risks considering existing flavivirus immunity.
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Tirzepatide, a glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor (GIPR/GLP-1R) agonist, has, in clinical trials, demonstrated greater reductions in glucose, body weight, and triglyceride levels compared with selective GLP-1R agonists in people with type 2 diabetes (T2D). However, cellular mechanisms by which GIPR agonism may contribute to these improved efficacy outcomes have not been fully defined. Using human adipocyte and mouse models, we investigated how long-acting GIPR agonists regulate fasted and fed adipocyte functions.

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The COVID-19 pandemic has raised the standard regarding the current vaccine development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines have proved their ability to induce strong immunogenicity and protective efficacy. We developed 1-methylpseudouridine-containing mRNA-LNP vaccines, expressing either the more conserved SARS-CoV-2 nucleoprotein (mRNA-N) or spike protein (mRNA-S), both based on the prototypic viral sequences. When combining both mRNA-S and mRNA-N together (mRNA-S+N), the vaccine showed high immunogenicity and broad protection against different SARS-CoV-2 variants, including wildtype, Delta, BA.

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  • Nitrogen-doped carbon submicrospheres (NCSMs) are created through a simple one-pot polymerization reaction at room temperature using dopamine hydrochloride, which provides both carbon and nitrogen.
  • The resulting NCSMs demonstrate impressive performance metrics, including an initial Coulombic efficiency of 84.8%, a sodium storage capacity of 384 mAh/g, and excellent cycling stability with 83.0% capacity retention after 2000 cycles.
  • This environmentally friendly synthesis method not only enhances sodium storage and transport dynamics but also presents a scalable approach for future sodium-ion battery commercialization.
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The long-term operation of motors induces substantial alterations in the surface conductivity and nonlinear coefficient of anti-corona paint, diminishing its efficacy and jeopardizing the longevity of large motors. Hence, the development of high-performance anti-corona paint holds paramount importance in ensuring motor safety. In this study, we integrate two nano-fillers, namely silicon carbide (SiC) and organic montmorillonite (O-MMT), into a composite matrix comprising micron silicon carbide and epoxy resin (SiC/EP).

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Background: Maternal-fetal immunology is intricate, and the effects of mRNA-S maternal vaccination on immune regulation at the maternal-fetal interface require further investigation. Our study endeavors to elucidate these immunological changes, enhancing our comprehension of maternal and fetal health outcomes. By analyzing immune profiles and cytokine responses, we aim to provide valuable insights into the impact of mRNA-S vaccination on the delicate balance of immune regulation during pregnancy, addressing critical questions in the field of reproductive pharmacology.

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Background: Gastric signet ring cell carcinoma (GSRCC) is a rare and highly malignant disease with a poor prognosis. To assess the overall survival (OS) and cancer-specific survival (CSS) of patients with GSRCC, prognostic nomograms were developed and validated using common clinical factors.

Methods: This retrospective cohort study included patients diagnosed with GSRCC between 2011 and 2018 from the National Cancer Center (n = 1453) and SEER databases (n = 2745).

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Soft composite solids are made of inclusions dispersed within soft matrices. They are ubiquitous in nature and form the basis of many biological tissues. In the field of materials science, synthetic soft composites are promising candidates for building various engineering devices due to their highly programmable features.

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Discovering effective anti-tumor drug combinations is crucial for advancing cancer therapy. Taking full account of intricate biological interactions is highly important in accurately predicting drug synergy. However, the extremely limited prior knowledge poses great challenges in developing current computational methods.

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Micro-supercapacitors, emerging as promising micro-energy storage devices, have attracted significant attention due to their unique features. This comprehensive review focuses on two key aspects: the scalable fabrication of MSCs and their diverse applications. The review begins by elucidating the energy storage mechanisms and guiding principles for designing high-performance devices.

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