Effects of Phenoxazine Chromophore on Optical, Electrochemical and Electrochromic Behaviors of Carbazole-Thiophene Derivatives.

Phenoxazine, as an organic-small-molecule chromophore, has attracted much attention for its potential electrochromic applications recently. To develop appealing materials, phenoxazine chromophores were introduced at the N-position of carbazole-thiophene pigment, yielding two novel monomers (DTCP and DDCP), whose chemical structures were characterized by NMR, HRMS and FTIR. The results of the optical property study indicate that little influence could be observed in the presence of the phenoxazine chromophore.

Design and Experiment of a PLC-Based Intelligent Thermal Insulation Box for Nursing Piglets.

Local heating of the activity area for nursing piglets is crucial for piglet health and the energy efficiency of barn climate control. Traditional heating methods using lamps or covers lack precise control, result in significant energy waste, and cannot be dynamically adjusted according to piglet age or changing environmental temperatures. To address these issues, this study designed a Programmable Logic Controller (PLC)-based thermal insulation box for nursing piglets, utilizing a strip heater instead of the conventional round heating lamp.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Development and validation of a nomogram for predicting the risk of obstructive coronary artery disease in rheumatoid arthritis patients based on LDL-C, Th17 cells, and IL-17.

Objective: This study aims to develop and validate a nomogram model for predicting the risk of obstructive coronary artery disease (CAD) in patients with rheumatoid arthritis (RA), incorporating low-density lipoprotein cholesterol (LDL-C), Th17 cells, and interleukin (IL)-17 levels. The proposed model seeks to enable personalized cardiovascular risk assessment for RA patients, thereby optimizing clinical management strategies.

Methods: A total of 120 patients with rheumatoid arthritis (RA) who were treated at the Second Hospital of Shanxi Medical University between January 2019 and September 2023 were enrolled in this study.

The miR-23a/27a/24 - 2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer.

Programmed cell death protein ligand-1 (PD-L1) and major histocompatibility complex I (MHC-I) are key molecules related to tumor immune evasion and resistance to programmed cell death protein 1 (PD-1)/PD-L1 blockade. Here, we demonstrated that the upregulation of all miRNAs in the miR-23a/27a/24 - 2 cluster was correlated with poor survival, immune evasion and PD-1/PD-L1 blockade resistance in patients with non-small cell lung cancer (NSCLC). The overexpression of all miRNAs in the miR-23a/27a/24 - 2 cluster upregulated PD-L1 expression by targeting Cbl proto-oncogene B (CBLB) and downregulated MHC-I expression by increasing the level of eukaryotic initiation factor 3B (eIF3B) via the targeting of microphthalmia-associated transcription factor (MITF).

A prediction approach to COVID-19 time series with LSTM integrated attention mechanism and transfer learning.

Background: The prediction of coronavirus disease in 2019 (COVID-19) in broader regions has been widely researched, but for specific areas such as urban areas the predictive models were rarely studied. It may be inaccurate to apply predictive models from a broad region directly to a small area. This paper builds a prediction approach for small size COVID-19 time series in a city.

TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation.

Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear.

Materials And Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer and .

Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells.

Paroxetine promotes longevity via ser-7-dop-4-IIS axis in Caenorhabditis elegans.

Paroxetine, a selective serotonin reuptake inhibitor, is widely used in the clinical treatment of depression. While several antidepressants show promise as geroprotectors, the role of paroxetine in aging remains unclear. In this study, we evaluated the lifespan extension effect of paroxetine in Caenorhabditis elegans (C.

Prevalence and Clinical Implications of Pulmonary Vein Stenosis in Bronchiectasis: A 3D Reconstruction CT Study.

Background: Recent studies on bronchiectasis have revealed significant structural abnormalities and pathophysiological changes. However, there is limited research focused on pulmonary venous variability and congenital variation. Through our surgical observations, we noted that coarctation of pulmonary veins and atrophied lung volume are relatively common in bronchiectasis patients.

Rapid Analysis of Nucleic Acids by Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry With a Data Algorithm.

Rationale: Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is a powerful method for identifying viruses via nucleic acid detection. The data processing method is critical in recognizing nucleic acid obtained by MALDI-TOF-MS. Therefore, new development of data algorithm is needed for virus identification.

Dual-Amplification Single-Particle ICP-MS Strategy Based on Strand Displacement Amplification-CRISPR/Cas12a Amplification for Homogeneous Detection of miRNA.

MicroRNAs (miRNAs) regulate a myriad of biological processes and thus have been regarded as useful biomarkers in biomedical research and clinical diagnosis. The specific and highly sensitive detection of miRNAs is of significant importance. Herein, a sensitive and rapid dual-amplification elemental labeling single-particle inductively coupled plasma-mass spectrometry (spICP-MS) analytical method based on strand displacement amplification (SDA) and CRISPR/Cas12a was developed for miRNA-21 detection.

Task-Allocation Decisions of Human-UAS Collaboration: Effects of Workload, Trust, and Self-confidence.

Uncrewed Aerial Systems (UAS) show promise in urban air transport, package delivery, and emergency services. UAS efficiency can be significantly improved by having multiple operators () managing a greater number of vehicles (), or the architecture of operation. The current study investigates how workload affects operators' task-allocation decision-making and the potential mediating effects of two crucial human factors, trust and self-confidence.

Large Language Model Ability to Translate CT and MRI Free-Text Radiology Reports Into Multiple Languages.

Background High-quality translations of radiology reports are essential for optimal patient care. Because of limited availability of human translators with medical expertise, large language models (LLMs) are a promising solution, but their ability to translate radiology reports remains largely unexplored. Purpose To evaluate the accuracy and quality of various LLMs in translating radiology reports across high-resource languages (English, Italian, French, German, and Chinese) and low-resource languages (Swedish, Turkish, Russian, Greek, and Thai).

Wide FOV metalens for near-infrared capsule endoscopy: advancing compact medical imaging.

This study presents the design, fabrication, and characterization of a wide field-of-view (FOV) metalens optimized for capsule endoscopy. The metalens achieved a 165° FOV with a high modulation transfer function (MTF) of 300 lines per millimeter (lp/mm) across the entire FOV, operating in the near-infrared (NIR) narrow-bandpass imaging at 940 nm. The performance of the metalens-based system is evaluated using two bandwidths, 12 nm and 32 nm, showing MTF values of 0.

The function and mechanism of clinical trial agent CPI-613 in multiple myeloma.

Multiple myeloma (MM) is an incurable malignant hematological neoplasm characterized by clonal proliferation of plasma cells accumulating in the bone marrow. Currently, the treatment of MM is usually based on a multi-drug combination strategy, and the remission rates of MM patients have been greatly improved. However, MM is still not immune to drug resistance and recurrence and is an incurable tumor.

Electrophysiological Signatures in Global Cerebral Ischemia: Neuroprotection Via Chemogenetic Inhibition of CA1 Pyramidal Neurons in Rats.

Background: Although there has been limited research into the perturbation of electrophysiological activity in the brain after ischemia, the activity signatures during ischemia and reperfusion remain to be fully elucidated. We aim to comprehensively describe these electrophysiological signatures and interrogate their correlation with ischemic damage during global cerebral ischemia and reperfusion.

Methods And Results: We used the 4-vessel occlusion method of inducing global cerebral ischemia in rats.

Sliding-tunable terahertz beam meta-deflector based on a 3D-printed bilayer.

To cope with the rapid preparation and tunable function of terahertz (THz) devices, a kind of THz beam meta-deflector (BMD) based on a bilayer metasurface doublet is proposed to implement tunable beam deflection with additional functions. By superimposing functional phases on one of the layers and sliding the other layer, the BMDs can achieve continuously beam deflection with beam splitting or beam focusing. It is possible to quickly switch between different functions by replacing the functional phase.

Establishment and evaluation of a risk prediction model for coronary heart disease in primary Sjögren's syndrome based on peripheral blood IL-6 and Treg percentages.

Objective: This study aims to establish and evaluate a risk prediction model for coronary heart disease (CHD) in patients with primary Sjögren's syndrome (pSS) based on peripheral blood levels of interleukin-6 (IL-6) and the percentage of regulatory T cells (Treg%). This model is intended to facilitate the timely identification of high-risk patients and the implementation of preventive measures.

Methods: Clinical data were collected from 120 pSS patients who visited the Second Hospital of Shanxi Medical University between November 2021 and September 2023.

Prevalence and genotypic characterization of zoonotic intestinal protozoan parasites in transboundary migratory Mongolian Gazelles (): the first survey.

The migration of Mongolian gazelles () poses a potential risk of outbreak for zoonotic intestinal protozoan parasite infections. This study aims to investigate the infection status of zoonotic intestinal protozoan parasites in these migratory Mongolian gazelles. We collected 120 fecal samples from Mongolian gazelles during their migration from Mongolia to China in December 2023.

Spin-Orbital Ordering Effects of Light Emission in Organic-Inorganic Hybrid Metal Halide Perovskites.

Organic-inorganic hybrid metal halide perovskites carrying strong spin-orbital coupling (SOC) have demonstrated remarkable light-emitting properties in spontaneous emission, amplified spontaneous emission (ASE), and circularly-polarized luminescence (CPL). Experimental studies have shown that SOC plays an important role in controlling the light-emitting properties in such hybrid perovskites. Here, the SOC consists of both orbital (L) and spin (S) momentum, leading to the formation of J (= L + S) excitons intrinsically involving orbital and spin momentum.

Lead accumulation and concomitant reactive oxygen species (ROS) scavenging in Robinia pseudoacacia are dependent on nitrogen nutrition.

Heavy metal pollution combined with nitrogen (N) limitation is a major factor preventing revegetation of contaminated land. Woody N-fixing legumes are a natural choice for phytoremediation. However, the physiological responses of woody legumes to lead (Pb) with low N exposure are currently unknown.

An evolutionary game study of traffic safety risk regulation considering public participation behavior.

With the development of transportation technology, the improvement of transportation efficiency also increases the complexity and diversity of traffic safety risks; the public's concern for traffic safety risks is increasing, and the traditional regulatory model is difficult to meet the improvement of the effectiveness of the safety regulation of the huge transportation network and the public's changing safety needs. In order to enhance the effectiveness of safety regulation, a game model of safety risk regulation among the public, transport enterprises, and regulators is constructed to simulate the effects of different traffic risks, penalty levels, and exposure rates on the behavior of transport enterprises and regulators. The results of the study show that: traffic risk has a positive facilitating effect on the participation of transport enterprises and the public in the regulation of safety risks, which will accelerate the process of stabilization of their strategies; transport enterprises have a high sensitivity to changes in the level of punishment, and only when the level of punishment exceeds a certain threshold will they be able to promote the choice of complying with the transport; and a higher exposure will lead to a greater tendency for transport enterprises to choose complying with the transport.

A study on the macro and micro mechanisms of cotton seedling growth regulation by high-voltage electrostatic field and optimization of system parameters.

Addressing the issues of inefficiency and severe environmental pollution associated with artificial and chemical methods in cotton growth regulation, this study introduces the high-voltage electrostatic field environmental control technology. It delves into the technology's macro- and microscopic impacts on cotton seedling growth and optimizes its operational parameters. At the macro level, the study examines the influence of adjusting the output voltage of the high-voltage electrostatic generator, the distance between the upper pole plate and the cotton leaf, and the action time of the electric field on seedling features above (plant height, ground diameter, and leaf area) and below ground (fresh weight and dry weight of roots).