Stable High-Entropy Alloy AlCoCrFeNi with Anti-Dealloying Effect for Enhanced Oxygen Evolution Performance.

The catalytic performance of oxygen evolution reaction (OER) catalysts is influenced by their elemental composition. Aluminum (Al) offers abundant active sites due to its high oxidation affinity, which makes it unstable in both acidic and alkaline environments. We used the gas atomization method (GAM) to prepare the aluminum-containing single-phase high-entropy alloy AlCoCrFeNi ( = 0, 0.

Transport mechanisms of pesticide mixtures impairing intestinal barrier function in mice.

Multiple pesticide residues in the diet can be ingested through the intestine; however, the interactions affecting intestinal health remain unclear. Histopathological analysis of mouse intestines revealed synergistic damage in those exposed to a binary mixture of abamectin, fluazinam, and spirodiclofen. The combined exposure to fluazinam and spirodiclofen resulted in a 73.

circEgg inhibits BmCPV infection by regulating the transition between H3K9me3 and H3K9ac.

Our previous study demonstrated that the expression level of circRNA circEgg, which is encoded by histone-lysine N-methyltransferase eggless (BmEgg), is responsive to Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection in the silkworm. However, the precise relationship between BmCPV infection and circEgg remains unclear. In this study, we observed that the expression level of circEgg in both the midguts and cultured BmN cells significantly increased after BmCPV infection, while the expression of its host gene, BmEgg, exhibited an opposite trend.

Analysis of the patient-sharing network in hypertension management: a retrospective study in China.

Objective: To explore the robustness of the patient-sharing network and validate the association between strength and persistence of physicians' relationships in China.

Design, Setting And Participants: We conducted a patient-sharing network analysis to describe the persistence of patient-sharing relationships and logistic regression to analyse factors associating with the persistence of patient-sharing relationships in the Yinzhou Health Information System from 1 January 2010 to 31 December 2018; all outpatient records that had a hypertension diagnosis were included in this study.

Outcome Measures: The persistence ratio was defined as the proportion of the patient-sharing relationships in a given year that continued to exist in the following year, the 1-, 2- and 3-year persistence to test the robustness of the findings.

Cardiovascular disease-specific and all-cause mortality across socioeconomic status and lifestyles among patients with established cardiovascular disease in communities of China: data from a national population-based cohort.

Background: Evidence of socioeconomic status (SES)-related health inequality is scarce in patients with cardiovascular diseases (CVDs) who need both lifestyle change and medical care, particularly in developing countries.

Methods: The study employed a nationwide population-based cohort design, covering all 31 provinces of Chinese mainland from September 2014 to March 2021. Participants aged 35-75 years with self-reported CVD diagnoses were included.

A Novel Sero-Specific-Gene Dependent Multiplex PCR Enhances the Discrimination of Major Serovars.

is a foodborne bacterial pathogen distributed worldwide. Serotyping is extensively applied in the classification of and is crucial in the early stage of epidemiological tracing. Among the 13 serovars, 1/2a, 1/2b, 1/2c, and 4b are the ones most frequently isolated.

Dissociation of Structural and Functional Connectivity and Metabolism in the Neocortex of Idiopathic Generalized Epilepsy: A Simultaneous PET/MRI Multimodal Study.

Background And Purpose: Idiopathic generalized epilepsy (IGE) accounts for approximately 20% of epilepsy cases. Characterized by generalized spike-wave discharge, IGE is increasingly recognized as a network disorder with potential metabolic underpinnings. This study leverages the advantages of simultaneous PET/MRI, which enables the concurrent acquisition of MRI and PET data, to integrate structural connectivity (SC), functional connectivity (FC), and glucose metabolism into a unified framework.

Status of Cardiac Magnetic Resonance in Clinical Application and Scientific Research: A National Survey in China.

Background: Cardiovascular magnetic resonance (CMR) is rapidly expanding in China, yet comprehensive national data on its clinical application and research status are limited. This study aims to evaluate the current landscape of CMR across the country.

Methods: An electronic survey was conducted targeting two groups: physicians trained at the Fuwai Fellowship Program and members of the Chinese Society of Radiology.

Association between breastfeeding and the risk of autoimmune diseases: A systematic review and meta-analysis.

Objectives: Previous studies on the association between breastfeeding and autoimmune diseases risk have yielded inconsistent findings. This study employed a systematic review and meta-analysis to explore the effect of breastfeeding and its duration against autoimmune diseases.

Methods: Six databases (PubMed, Web of Science, Embase, CINAHL, Cochrane Library, PsycINFO) were systematically searched from inception to September 24, 2024.

Apolar oil favored interfacial curcumin complexation onto goose liver protein improves the high internal phase emulsion templated oleogel characters.

The curcumin complexation onto goose liver protein (GLP) at interface for high internal phase emulsions (HIPEs) property enhancement as well as plant oil (sunflower oil, corn oil and flaxseed oil) based oleogels stabilization were elucidated. Interfacial pressure and rheology showed that oily dispersed curcumin and its complexation strengthened the GLP adsorption and intermolecular assembly, especially for apolar flaxseed oil. Frequency sweep and micromorphology of HIPEs suggested that flaxseed oil and curcumin complexation rendered the highest droplet packing density with least size dimension (40.

Metal ion of metal-organic frameworks facilitating immobilized chitinase performance.

Metal-organic framework (MOF) structures containing different metal ions and 1,3,5-trimesic acid (BTC) were fabricated, as the carriers to immobilize chitinase (Chi) for improving the performance of Chi, for the first time. It was found that the immobilization of Chi on Ca-BTC, Ba-BTC, and Ni-BTC increased its activity. Notably, the specific activity of Chi@Ca-BTC was enhanced by 2.

Structure-activity relationships of polyphenol-rice starch complexes: Impact on 3D printing and resistant starch formation.

This study aimed to investigate the effects of gallic acid (GA), luteolin (LUT), and quercetin (QUE) on the structure, physicochemical characteristics, and 3D printing behavior of rice starch and to elucidate the underlying mechanisms. The results revealed that incorporating GA significantly decreased the viscoelasticity of rice starch, reducing the printing accuracy from 98.64 % to 72.

Hepatoma-derived growth factor promotes liver carcinogenesis by inducing phosphatase and tensin homolog inactivation.

Hepatoma-derived growth factor (HDGF) is located on chromosome 1q21-23, a locus frequently amplified in hepatocellular carcinoma (HCC), and has been proposed as an oncogenic factor by stimulating PI3K/Akt signaling. Phosphatase and tensin homolog (PTEN) acts as a tumor suppressor that antagonizes PI3K/Akt signaling, suggesting a possible regulatory effect of HDGF on PTEN. Here, we aimed to investigate the regulatory role of HDGF on PTEN.

BDD electrode pulsed alternating electrochemical oxidation of sulfamethazine in antibiotic wastewater: Process optimization and degradation mechanism.

To address the issues of electrode passivation and high electric energy consumption (EEC) associated with the removal of antibiotic wastewater using traditional direct current electrocatalytic oxidation (DCEO) with Boron-Doped Diamond (BDD) electrodes, this study aims to develop an efficient, low-cost, and self-cleaning BDD electrode pulsed alternating electrocatalytic oxidation (BDD-PAEO) technology. The experimental findings demonstrated that, under optimal conditions, the BDD-PAEO mode achieved a 99.9% removal efficiency for sulfamethazine (SMZ).

Associations of family socioeconomic status during childhood with cognitive development in later life in China: A population-based cohort study.

Background: Childhood is a critical period for brain growth and cognitive development, most of the previous research examined the impact of family socioeconomic status (SES) on cognitive functioning primarily focused on middle-aged and older adults. We aimed to examine the association between family SES in childhood and offspring's cognitive performance in later life, and whether the relationship was mediated by parental healthy lifestyle.

Methods: A total of 5467 children aged 6-15 years were included in 2010 as baseline and 1789 offspring aged 14-23 years who had valid cognitive test scores were investigated in 2018.

Gender-specific network analysis of parenting styles, depressive symptoms, and anxiety symptoms among 5157 Chinese adolescents.

Background: In this study, we aimed to use network analyses to explore the gender-specific interactions between individual items of depressive symptoms, anxiety symptoms, and parenting styles in Chinese adolescents.

Methods: We conducted a cross-sectional study with a total of 5157 adolescents in 5 primary schools, 8 junior high schools, and 2 senior high schools in Shandong province, China. Male and female adolescents' networks were assessed in all grades using the Egna Minnen Betraffande Uppfostran (EMBU), the 9-item Patient Health Questionnaire (PHQ-9), and the 7-item Generalized Anxiety Disorder Assessment (GAD-7).

Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease.

Background: Previous studies have reported Parkinson's disease (PD) patients usually have changes in brain image-derived phenotypes (IDPs). However, the role of genetic factors in their association and biological mechanism remains unclear. We aimed to unveil genetic and biological links between brain IDPs and PD.

Arsenic and metabolic diseases: New insights from mesenchymal stem cells.

Arsenic is a common toxic metal contaminant in the environment. Humans are exposed to arsenic through drinking water, air, food, and medical treatment. Chronic exposure to arsenic is a well-documented risk factor of type 2 diabetes and a potential risk factor of osteoporosis and obesity.

Predicting diabetic retinopathy based on biomarkers: Classification and regression tree models.

Objective: We choose the classification and regression tree (CART) model as the analysis tool to identify clinical indicators that assess the risk factors for diabetic retinopathy (DR) and to determine the key risk factors associated with DR.

Methods: In this study, a total of 781 patients with diabetic mellitus(DM) were enrolled, including 395 patients with diabetic retinopathy(DR) and 386 patients without diabetic retinopathy. Univariate and multivariate logistic regression analysis were used to assess the risk factors of DR.

Engineering Halomonas bluephagenesis for Pilot Production of Terpolymers Containing 3-Hydroxybutyrate, 4-Hydroxybutyrate and 3-Hydroxyvalerate) from Glucose.

Microbial poly(3-hydroxybutyrate-co-4-hydroxybutyrate-co-3-hydroxyvalerate), abbreviated as P(3HB-4HB-3HV) or P34HBHV, is a flexible polyhydroxyalkanoate (PHA) material ranging from softness to elasticity depending on the ratios of various monomers. Halomonas bluephagenesis, as the chassis of the next generation industrial biotechnology (NGIB) able to grow contamination free under open unsterile conditions. The resulting recombinants of H.

Anti-breast cancer effect of Phellinus pini and its chemical composition characterization.

Phellinus pini (P. pini) has been widely utilized as a traditional medicinal macrofungus in China and various East Asian countries. Modern pharmacological studies have shown that P.

Sex-specific UGT expression and function: prevalence, potential mechanisms and significance.

Introduction: Sex and gender influence pharmacotherapy outcomes, including adverse drug effects which are nearly twice as common in women. Sex differences in drug responses involve factors as diverse as body composition, physiology, and prescribing patterns. Many drugs show higher exposure in women, which can be partly attributed to sex-differences in processes that control drug disposition such as metabolism and transport.

Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration.

Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders associated with mitogen-activated protein (MAP)-kinase-activating mutations and an increased risk of neurodegeneration. We found microglial mutant clones in LCH and ECD patients, whether or not they presented with clinical symptoms of neurodegeneration, associated with microgliosis, astrocytosis, and neuronal loss, predominantly in the rhombencephalon gray nuclei. Neurological symptoms were associated with PU.

Biomaterial-based drug delivery strategies for oral mucosa.

Drug therapy is a key field in modern medicine, and the optimization of its delivery method is crucial. Traditional methods are inherently limited by first-pass effects, high-risk adverse reactions, and patient compliance challenges, which significantly restrict the effectiveness and application potential of drugs. Oral mucosal drug delivery has become a minimally invasive and effective drug delivery strategy.

Evidence of SUFBCD directly deliver Fe-S cluster to apo- NITRITE REDUCTASE1 (NIR1).

Fe-S clusters are ancient, ubiquitous, and highly essential prosthetic groups of many proteins. According to current understanding, Fe-S clusters are biosynthesized on scaffold, and transferred to carrier proteins, thereafter, they will be inserted into apo-proteins. However, it was also suggested that the scaffold complex SUFBCD can directly deliver Fe-S cluster to apo-proteins.