Clinical study of ligustrazine combined with radial extracorporeal shock wave therapy in stroke patients with upper limb spasticity.

Upper limb spasticity is a common and serious sequelae in patients with hemiplegia after stroke. Radial extracorporeal shock wave therapy (rESWT) can improve upper limb dysfunction and relieve pain in patients, However, its efficacy as a single treatment is limited. In traditional Chinese medicine, Tetramethylpyrazine (TMP) is the main pharmacological component of Ligusticum chuanxiong.

Analysis of Chemical Composition of Long-Chain Linear Alkylbenzenes Using High-Performance Liquid Chromatography Coupled with Microwave Plasma Torch Mass Spectrometry.

Long-chain linear alkylbenzenes (LABs) are essential precursors to produce alkylbenzene sulfonates, which have high surfactant properties and are readily biodegradable, widely used in various detergents. However, an effective and rapid method for the direct analysis and quality control of LAB chemical composition still needs to be improved. This study uses high-performance liquid chromatography coupled with microwave plasma torch mass spectrometry (HPLC-MPT-MS) to analyze the composition of long-chain LABs and quantify nine of these components.

CT-Based radiomics nomogram of lung and mediastinal features to identify cardiovascular disease in chronic obstructive pulmonary disease: a multicenter study.

Rationale And Objectives: To investigate the performance of two diagnostic models based on CT-derived lung and mediastinum radiomics nomograms for identifying cardiovascular disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD) patients.

Materials And Methods: Hospitalized participants with COPD were retrospectively recruited between September 2015 and April 2023. Clinical data and visual coronary artery calcium score (CACS) were collected.

Survival benefit of surgery vs radiotherapy alone to patients with stage IA lung adenocarcinoma: a propensity score-matched analysis.

Objectives: We compared the overall survival (OS) and cancer-specific survival (CSS) of patients who received radiotherapy and surgery, respectively, in a large population.

Methods: In this study, we counted the patients diagnosed with stage IA lung adenocarcinoma in the SEER database from 2015 to 2019. We compared the overall survival (OS) and cancer-specific survival (CSS) through Kaplan Meier analysis, balanced the differences of primary data through propensity score matching (PSM), screened independent prognostic factors through Cox regression analysis, and then compared the survival differences of different treatment methods through hierarchical analysis.

Exploring the potential benefits of growth hormone co-treatment on embryo quality in IVF: a randomized controlled open-label trial.

Research Question: While growth hormone (GH) is hypothesized to potentially enhance embryo quality, results of current basic and clinical researches remain inconclusive. This study assesses the effect of GH supplementation on embryo quality and explores the relationship between baseline insulin-like growth factor-1 (IGF-1) levels and the efficacy of GH supplementation among Chinese patients undergoing in vitro fertilization (IVF).

Design: A randomized controlled Open-label trial was performed with 128 women experiencing poor embryonic development in IVF.

IFN-γ signaling links ventriculomegaly to choroid plexus and ependyma dysfunction following maternal immune activation.

Maternal immune activation (MIA) is a principal environmental risk factor contributing to autism spectrum disorder (ASD) and can be causally linked to ASD symptoms. In our study, we found that MIA triggered by poly (I: C) injection caused ventriculomegaly in offspring due to the dysfunction of the choroid plexus (Chp) and ependyma. We subsequently identified a sustained enhancement of interferon-γ (IFN-γ) signaling in the brain and serum of MIA offspring.

Circulating miR-486-3p as a potential biomarker for the diagnosis of gestational diabetes mellitus and the prediction of adverse pregnancy outcomes.

Objective: Gestational diabetes mellitus (GDM) seriously endangers the health of pregnant women and their offspring. Early prediction and diagnosis allow timely treatment of GDM, preventing adverse pregnancy outcomes and related diseases. This research aims to explore the predictive significance of miR-486-3p expression levels in diagnosing GDM in early pregnancy.

LINC02363: a potential biomarker for early diagnosis and treatment of sepsis.

Background: Sepsis remains a leading cause of global morbidity and mortality, yet early diagnosis is hindered by the limited specificity and sensitivity of current biomarkers.

Aim: The aim of this study was to identify lncRNAs that play a key role in sepsis and provide potential biomarkers for the diagnosis and treatment of sepsis.

Methods: Transcriptomic data from sepsis patients were retrieved from the Chinese National Genebank (CNGBdb).

Omega-6 polyunsaturated fatty acids and their metabolites: a potential targeted therapy for pulmonary hypertension.

Pulmonary hypertension (PH) is a progressive and life-threatening cardiopulmonary disease that is not uncommon. The modulation of the pulmonary artery (PA) involves various fatty acids, including omega-6 polyunsaturated fatty acids (ω-6 PUFAs) and ω-6 PUFAs-derived oxylipins. These lipid mediators are produced through cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP450), and non-enzymatic pathways.

Older adult's acceptance and uptake of referral after screening for cognitive impairment: a cross-sectional study in China.

Background: Previous studies have shown that the referral situation after cognitive screening is not optimistic. However, little is known about the situation in China. The current study assessed the cognitive function of older adults with an Eight-item Ascertain Dementia (AD8) score of ≥ 2 in a community health center and investigated their willingness to accept referrals.

Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation.

Objective: This study aimed to investigate the causal relationship between inflammatory cytokines and oral cavity cancer risk using Mendelian randomization analysis and experimental validation.

Methods: Two-sample Mendelian randomization was conducted using summary-level genome-wide association study data on 41 inflammatory cytokines and oral cavity cancer risk in Europeans. Single nucleotide polymorphisms associated with cytokines (p < 5 × 10-6) and oral cancer were selected as instrumental variables, excluding those in linkage disequilibrium.

The comparative efficacy of L-glutamine, celecoxib, and glucosamine sulfate in osteoarthritis management.

To explore the therapeutic efficacy of L-glutamine (L-Gln) on pathological progression and clinical symptoms of osteoarthritis (OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting from the fifth week after sham operation or Anterior Cruciate Ligament Transection (ACLT) + Medial Meniscectomy (MMx). Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination.

Identification and validation of a major QTL, QFhb-6AL, for Fusarium head blight resistance on chromosome 6AL in wheat.

A novel major QTL, QFhb-6AL, accounting for 34.6% phenotypic variation for FHB resistance, was identified in the Chinese cultivar Xunong 029, and a near-diagnostic marker was developed for marker-assisted selection. Fusarium head blight (FHB) is a destructive disease in wheat (Triticum aestivum L.

mPEG-PCL modified Caffeic acid eye drops for endotoxin-induced uveitis treatment.

The modulation of inflammatory mediators has emerged as a critical therapeutic strategy in uveitis management. Current nonsteroidal anti-inflammatory therapies face limitations due to systemic side effects. Caffeic acid (CA), a natural polyphenol with anti-inflammatory properties, holds therapeutic potential but suffers from poor solubility and ocular irritation.

Influence of 3D printing angles on the accuracy of indirect adhesion transfer models: an in vitro study.

The aim of this study was to evaluate the effect of different Angle printing on the model on the printing platform and whether it affects the later transfer accuracy. Ten bracket transfer models were printed on the platform of the 3D printer in four ways: 0° without support rod, 0°, 45° and 90° with support rod. Transfer guide plates for transfer brackets were made using PVS.

Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.

Previous studies have demonstrated that silica can activate the NLRP3 inflammasome, and that macrophage phagocytosis is an essential step in this process. Although carbon is the primary component of coal dust particles, it also contains other impurities such as free silica, clay, sulfides, and carbonate minerals. Additional research is still necessary to discover if NLRP3 can be triggered due to the low silica content of coal dust particles.

Theoretical model and experimental verification of seepage-transition-spontaneous imbibition in water migration of water-injected coal.

Coal seam water injection is widely applied to prevent mine disasters. In the traditional water migration model of water-injected coal, from ignoring capillary force in the seepage stage to generating the capillary dynamic during the spontaneous imbibition state, no transition state exists from 0 to generating capillary force. In this paper, on the basis of theoretical analysis, an equivalent capillary term is introduced to modify the Forchheimer model, and then a seepage-transition-spontaneous imbibition model that is suitable for water migration of water-injected coal is proposed.

Lentinan suppresses the progression of neuroblastoma by inhibiting FOS-mediated transcription activation of VRK1 to stabilize p53 protein.

Neuroblastoma (NB) is a common malignant and solid pediatric tumor with unfavorable prognosis. Although studies have shown the anti-tumor efficacy of lentinan (LNT), molecular mechanism that contribute to the anti-tumor effect on NB remains unclear. The aim of this study is to unmask the anti-tumor role of LNT in NB and the specific molecular mechanism.

Association between cardiac cachexia and adverse outcomes in patients with heart failure: a meta-analysis of cohort studies.

Background: Cardiac cachexia is a condition characterised by unintentional weight loss and muscle wasting in patients with heart failure. However, there is debate about the prognostic value of cardiac cachexia in these patients.

Objectives: This meta-analysis aimed to evaluate the prognostic value of cardiac cachexia in patients who had heart failure.

The Consistency of Plasma Catecholamines and Metanephrines Analysis in China: A Comparison of Three Mainstream Commercially Available Liquid Chromatography Tandem Mass Spectrometry Kit Methods.

Objective: The consistency of plasma catecholamines and metanephrines measurements is crucial for the screening and diagnosis in pheochromocytomas and paragangliomas (PPGLs). There are many commercially available kits for plasma catecholamines and metanephrines testing, but their performance and consistency information are unknown. This study evaluated the performance of three mainstream commercially available LC-MS/MS kit methods and evaluated their consistency.

Oral ADC189 for Adults and Adolescents with Uncomplicated Influenza.

Objectives: ADC189 is a novel anti-influenza virus inhibitor. In this study, we aimed to evaluated the safety and efficacy of ADC189 in outpatients with uncomplicated influenza infection.

Methods: In the phase 2 trial, we assigned patients in a 2:2:1 ratio to receive either single dose 15-mg or 45-mg of ADC189 or placebo.

Exploring the tissue distribution propensity of active alkaloids in normal and stomach heat syndrome rats following oral administration of Zuojin Pill based on pharmacokinetics and mass spectrometry imaging.

Ethnopharmacological Relevance: Zuojin Pill (ZJP) is a traditional Chinese medicine (TCM) formula composed of Coptidis Rhizoma and Euodiae Fructus in a ratio of 6:1 (w/w), which has been widely used for treating gastrointestinal disorders, especially stomach heat syndrome (SHS). However, the active alkaloids in ZJP showed low plasma exposure in rats following oral administration, which failed to explain their potent pharmacological effects, thereby limiting further mechanism studies.

Aim Of The Study: This study aimed to investigate the in vivo exposure and tissue distribution propensities of the active alkaloids in normal and SHS rats following oral administration of ZJP.