Publications by authors named "Htet Myat Win Maung"
This study aimed to characterize whole-genome sequencing (WGS) information of (Mtb) in the Mandalay region of Myanmar. It was a cross-sectional study conducted with 151 Mtb isolates obtained from the fourth nationwide anti-tuberculosis (TB) drug-resistance survey. Frequency of lineages 1, 2, 3, and 4 were 55, 65, 9, and 22, respectively.
View Article and Find Full Text PDFMycobacterium tuberculosis (Mtb) lineage 1 (L1) contributes considerably to the disease morbidity. While whole genome sequencing (WGS) is increasingly used for studying Mtb, our understanding of genetic diversity of L1 remains limited. Using phylogenetic analysis of WGS data from endemic range in Asia and Africa, we provide an improved genotyping scheme for L1.
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- * New advancements in whole-genome sequencing (WGS) allow for a deeper understanding of the genetic diversity of Mtb L2, leading to a revised classification scheme that includes over 30 genotypes and better identifies Modern Beijing strains.
- * The newly proposed SNP-based genotyping method accurately classifies over 98% of L2 isolates, enhancing monitoring of TB transmission, outbreaks, and associations with disease severity and drug resistance.
Worldwide, studies investigating the relationship between the lineage of (MTB) across geographic areas has empowered the "End TB" program and understand transmission across national boundaries. Genomic diversity of MTB varies with geographical locations and ethnicity. Genomic diversity can also affect the emergence of drug resistance.
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